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A traditional Chinese medicine composition for preventing and treating cognitive impairment in diabetes and its preparation method

A technology for cognitive impairment and composition, which is applied in the direction of drug combination, pharmaceutical formula, medical preparations containing active ingredients, etc., to achieve the effect of definite curative effect, not easy to agglomerate, and improve cognitive impairment

Active Publication Date: 2020-02-07
SHANDONG ACAD OF CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Syndrome differentiation is mostly marrow sea deficiency, heart and spleen deficiency, kidney deficiency and blood stasis, and phlegm obstruction. Advantages of multi-channel and multi-target effects, but most of them are in the stage of experimental research, and no drugs have yet been launched on the market

Method used

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  • A traditional Chinese medicine composition for preventing and treating cognitive impairment in diabetes and its preparation method
  • A traditional Chinese medicine composition for preventing and treating cognitive impairment in diabetes and its preparation method
  • A traditional Chinese medicine composition for preventing and treating cognitive impairment in diabetes and its preparation method

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Embodiment

[0048] 1. Quality standards for excipients

[0049] Soluble starch (Soluble Starch): The starch of this strain is processed by enzymatic or acid hydrolysis to improve its solubility in water. This product is white or off-white powder. Its quality should meet the relevant regulations under the soluble starch item on page 494 of the fourth part of the 2015 edition of the Chinese Pharmacopoeia.

[0050] 2. Pretreatment of drugs

[0051] (1) Preparation of Radix Polygoni Multiflori: Break the commercially available decoction pieces into 0.5 cm small pieces and set aside.

[0052] (2) Yanyizhiren: moderately crush the commercially available decoction pieces until they are white, and set aside.

[0053] (3) Polygala: Break the commercially available decoction pieces into 0.5 cm pieces for later use.

[0054] 3. Formulation and preparation method

[0055] (1) Weigh 144g astragalus, 60g Polygonum multiflorum, 60g Yizhiren, 60g Epimedium, 36g male silk moth, 54g Rehmannia glutinos...

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Abstract

The invention relates to a traditional Chinese medicine composition for preventing and treating cognitive impairment in diabetes and a preparation method thereof. The raw material medicine consists of: 20-26 parts of Astragalus membranaceus, 8-11 parts of Polygonum multiflorum, 8-11 parts of Yanzhiren, and 8 parts of Epimedium. ‑11 portions, 4‑7 portions of male silkworm moth, 8‑10 portions of Rehmannia glutinosa, 13‑17 portions of Salvia miltiorrhiza, 2‑5 portions of polygala root, and 1‑3 portions of Coptis chinensis. The preparation method includes the following steps: (1) Distilling and extracting volatile oil from Yanzhizhiren; (2) Refluxing and extracting Polygonum multiflorum and Coptis chinensis with ethanol; (3) Refluxing and extracting male silkworm moth and Salvia miltiorrhiza with ethanol; (4) Extracting Astragalus membranaceus and Epiphylla miltiorrhiza by refluxing with ethanol; Sheep weed, Rehmannia glutinosa and polygala raw materials are prepared and the steps are (2) decocting the medicinal residue; (5) combining and concentrating the water and liquid, adding alcohol extraction concentrate, and concentrating again to obtain a thick paste; (6) adding soluble starch to make granules , dry, spray into the volatile oil of salt and aphrodisiac, mix well, and place in an airtight container. Pharmacological experiments have proven that the formula of the present invention is reasonable, has significant efficacy, and has definite curative effect, and has obvious effects of lowering blood sugar and improving cognitive impairment caused by type 2 diabetes.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition for preventing and treating diabetic cognitive impairment, a preparation method and application thereof. It belongs to the field of traditional Chinese medicine technology and traditional Chinese medicine treatment. Background technique [0002] Diabetes is a metabolic disorder syndrome characterized by hyperglycemia, and its incidence is increasing year by year. According to statistics from the International Diabetes Federation in 2013, the global prevalence of diabetes among adults aged 20 to 79 was 8.3%, and the number of patients reached 382 million; the number of people with diabetes in China was 98.4 million, ranking first in the world. With the increasing number of diabetic patients year by year, the cognitive impairment caused by it has become a concern. Cognitive impairment refers to the pathological process in which the brain's advanced intelligence processing process relat...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/9062A61K9/16A61P3/10A61P25/28A61K35/64
CPCA61K36/9062A61K9/1652A61K35/63A61K36/296A61K36/481A61K36/537A61K36/69A61K36/704A61K36/718A61K36/804A61K2236/331A61K2236/333A61K2236/39A61K2300/00
Inventor 李莹程丽芳冯建华张新军刘瑾王爱洁隋在云张丽美周倩
Owner SHANDONG ACAD OF CHINESE MEDICINE
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