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Preparation method of corn stigma oral liquid capable of lowering blood glucose

A technology of corn silk and oral liquid, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc. High, good taste, obvious effect

Inactive Publication Date: 2017-05-10
杨挺
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The researchers extracted functional components from corn silk by various methods such as dipping method, decoction method, reflux extraction method, continuous reflux extraction method, etc., but the content of functional components in the extract was not high, there were many impurities, and the taste was sour

Method used

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  • Preparation method of corn stigma oral liquid capable of lowering blood glucose
  • Preparation method of corn stigma oral liquid capable of lowering blood glucose

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) Wash 100g of high-quality corn silk, dry it and pulverize to obtain corn silk powder, add 1500g deionized water, use 8.5g cellulase, 17g carboxylesterase and 4.5g papain at 50℃, PH5 , Enzymatic hydrolysis for 5 hours.

[0026] (2) Heat 130 g of the enzymatic hydrolysate obtained in step (1) to boiling, keep it for 8 minutes to inactivate the enzyme, then cool to room temperature, and centrifuge to obtain 102 g of corn silk clear liquid;

[0027] (3) Pour the corn silk clear obtained in step (2) into 1000 g of chloroform, sonicate for 10 minutes, then stand for stratification, take the supernatant liquid, freeze-dry for 24 hours to obtain 28 g of corn silk extract;

[0028] (4) Mix 5 g corn silk extract obtained in step (3), 0.1 g calcium stearoyl lactate, 10 g sucrose, 0.05 g potassium sorbate and 100 g purified water to obtain the desired blood sugar lowering corn silk oral liquid.

Embodiment 2

[0030] (1) Wash 100g of high-quality corn silk, dry it, and then pulverize it to obtain corn silk powder, add it to 1800g deionized water, and use 14g cellulase, 29g carboxylesterase and 7g papain at 60°C and pH6. Solution for 6 hours.

[0031] (2) Heat 150 g of the enzymatic hydrolysate obtained in step (1) to boiling, keep it for 10 minutes to inactivate the enzyme, then cool to room temperature, and centrifuge to obtain 115 g of corn silk clear liquid;

[0032] (3) Pour the corn silk clear night obtained in step (2) into 1000 g of chloroform, sonicate for 5 minutes, then stand for layering, take the supernatant liquid, freeze-dry for 24 hours to obtain 32 g of corn silk extract;

[0033] (4) Mix 5 g corn silk extract obtained in step (3), 0.15 g calcium stearoyl lactate, 5 g sucrose, 0.1 g potassium sorbate and 50 g purified water to obtain the desired blood sugar lowering corn silk oral liquid.

Embodiment 3

[0035] (1) Wash 100g of high-quality corn silk, dry it and pulverize to obtain corn silk powder, add it to 2000g deionized water, use 11.5g cellulase, 23g carboxylesterase and 5.5g papain at 70°C, pH4 , Enzymatic hydrolysis for 3 hours.

[0036] (2) Heat 140 g of the enzymatic hydrolysate obtained in step (1) to boiling, keep it for 5 minutes to inactivate the enzyme, then cool to room temperature, and centrifuge to obtain 105 g of corn silk clear liquid;

[0037] (3) Pour the corn silk clear night obtained in step (2) into 840 g of chloroform, sonicate for 8 minutes, then stand for layering, take the supernatant liquid, freeze-dry for 24 hours to obtain 35 g of corn silk extract;

[0038] (4) Mix 5 g corn silk extract obtained in step (3), 0.05 g sodium stearoyl lactylate, 8 g sucrose, 0.15 g potassium sorbate and 80 g purified water to obtain the desired blood sugar lowering corn silk oral liquid.

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Abstract

The invention provides a preparation method of a corn stigma oral liquid capable of lowering blood glucose. The method comprises steps as follows: (1) superior corn stigmas are washed clean, dried in the sun and crushed, and corn stigma powder is obtained, added to deionized water and subjected to enzymolysis by compound enzyme at 50-70 DEG C with the PH ranging from 4 to 6 for 3-6 h; (2) an enzymatic hydrolysate obtained in step (1) is heated to be boiled, kept at the constant temperature for 5-10 min for enzyme deactivation, cooled to the room temperature and centrifuged, and a clear corn stigma liquid is obtained; (3) the clear corn stigma liquid obtained in step (2) is poured into trichloromethane, subjected to ultrasonic treatment for 5-10 min and left to stand for layering, a supernatant is taken and freeze-fried for 24 h, and a corn stigma extract is obtained; (4) the corn stigma extract obtained in step (3), an emulsifier, sucrose, potassium sorbate and purified water are evenly mixed, and thus the corn stigma oral liquid capable of lowering blood glucose is obtained. The prepared corn stigma oral liquid has high polysaccharide and flavonoid content, has an obvious blood glucose lowering effect, has no side effects and is suitable to be taken by patients for a long time.

Description

Technical field [0001] The invention belongs to the technical field of food health care, and specifically relates to a preparation method of a corn silk oral liquid for lowering blood sugar. Background technique [0002] Corn is one of the most widely distributed food crops in the world, and its planting area is second only to wheat and rice. The US's corn production accounts for about half of the world's output, and it is the most important food crop. China's annual corn production ranks second in the world and is widely distributed. It is one of the main foods for the people in the mountainous areas of northern and southwestern China and other dry valley areas. . Maize silk is the style and stigma of maize. The earliest medicinal records are found in "Wood grass in South Yunnan" in 1476. It is a common medicinal species 11l included in the "Medicinal Material Standards of the Ministry of Health of the People's Republic of China" 1985 (Part 1). , Antibacterial, hypolipidemic, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/899A61K9/08A61P3/10A23L33/105
CPCA23V2002/00A61K9/0053A61K9/08A61K36/899A61K47/26A61K2236/19A61K2236/35A23V2200/328A23V2250/21A23V2250/628A23V2300/14Y02A40/90
Inventor 杨挺
Owner 杨挺
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