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Calcium dobesilate capsule and preparation method

A calcium dobesilate, capsule technology, applied in capsule delivery, anhydride/acid/halide active ingredients, metabolic diseases, etc., can solve problems such as differences in clinical effects and hidden dangers in disease treatment, and achieve the effect of reducing large variability

Inactive Publication Date: 2017-05-10
北京满格医药科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

These all lead to differences in clinical effects and bring hidden dangers to disease treatment.

Method used

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  • Calcium dobesilate capsule and preparation method
  • Calcium dobesilate capsule and preparation method
  • Calcium dobesilate capsule and preparation method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] prescription:

[0025]

[0026] Preparation process: Pass calcium dobesilate, lactose, and magnesium stearate through an 80-mesh sieve, and set aside; weigh the prescription amount of calcium dobesilate and lactose, mix them evenly, and wet them with 10% ethanol solution on a high-speed wet granulator. Dry the wet granules, sieve and granulate, add the prescribed amount of magnesium stearate and mix, dry granulate in a dry granulator, and fill.

Embodiment 2

[0028] prescription:

[0029]

[0030] Preparation process: with embodiment 1

Embodiment 3

[0032] prescription:

[0033]

[0034] Preparation process: Pass calcium dobesilate, pregelatinized starch, and magnesium stearate through an 80-mesh sieve, and set aside; weigh the prescription amount of calcium dobesilate and pregelatinized starch, put them in a fluidized bed granulator, and use The 10% ethanol solution is granulating, the wet granules are dried, sieved and granulated, the prescription amount of magnesium stearate is added and mixed, dry granulated in a dry granulator, and filled.

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PUM

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Abstract

The invention relates to a calcium dobesilate capsule and a preparation method, and belongs to the technical field of pharmaceutical preparations. According to the technical scheme, the calcium dobesilate capsule is prepared from a therapeutically effective dose of calcium dobesilate, filler and a lubricant. The capsule is characterized by being produced with a wet granulation and dry granulation combined process. The materials are subjected to wet granulation before the dry granulation process, the problem of poor mobility due to too large proportion of calcium dobesilate in a prescription is solved, and the problem of high variability of each sample in the early stage of the dissolution process is also solved.

Description

[0001] Technical field: [0002] The invention relates to a calcium dobesilate capsule and a preparation method thereof, belonging to the technical field of pharmaceutical preparations. [0003] Background technique: [0004] Diabetes is a disease in which excess glucose tends to accumulate in the blood. With the improvement of people's living standards, the aging population and the increase of obesity rate, the incidence of diabetes in my country has an upward trend. The onset of diabetes is slow, the symptoms are hidden, the condition is complicated, and it is often combined with various complications. Retinopathy, nephropathy and neurological disorders are known as the three major complications of diabetes. When treating diabetes, it is necessary to treat these complications. Calcium dobesilate has its unique curative effect in the treatment of diabetic retinopathy. [0005] Calcium dobesilate capsules were put on the market in Europe in the 1970s and are mainly used cli...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/185A61K47/36A61K47/38A61P3/10A61P9/10
CPCA61K9/1682A61K9/1652A61K31/185
Inventor 李进梁屹汪娟
Owner 北京满格医药科技有限公司
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