Synthesis method of ultraviolet fluorescence molecule probe, and nitrite ion detection of probe

A fluorescent molecular probe, nitrite technology, applied in fluorescence/phosphorescence, color/spectral property measurement, material analysis by optical means, etc. The effect of stable optical properties, good specificity and long storage time

Active Publication Date: 2017-04-26
LANZHOU UNIVERSITY +1
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  • Claims
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Problems solved by technology

However, when these two methods detect nitrite ions, a variety of reagent combinations are required. The reagents of the Gries method are prepared by mixing the phosphoric acid solution of sulfanilamide aqueous solution and naphthalene ethylenediamine, and the detection steps are cumbersome and complicated. , it needs to be stored in the dark and refrigerated, and it will be used up within half an hour. The reagent is difficult to store, takes a long time, and needs to be reacted under the action of strong acid

Method used

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  • Synthesis method of ultraviolet fluorescence molecule probe, and nitrite ion detection of probe
  • Synthesis method of ultraviolet fluorescence molecule probe, and nitrite ion detection of probe
  • Synthesis method of ultraviolet fluorescence molecule probe, and nitrite ion detection of probe

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Embodiment 1

[0035] Put 661 mg of 5-aminoindole in a 250 mL round bottom flask, dissolve it in 100 mL of anhydrous acetonitrile, stir at room temperature, and add 7.5 mL of triethylamine and 18 mg of 4-dimethylaminopyridine under nitrogen protection . Dissolve 510 mg of 2,6-pyridinedicarboxylic acid chloride in anhydrous acetonitrile, and drop it into the above solution, white smoke will be generated immediately, stir at room temperature for 12 hours, until a solid precipitates out, evaporate the solvent after the reaction is completed , the solid was washed with water, filtered, washed three times with acetonitrile, and dried under vacuum at 30°C to obtain the ultraviolet fluorescent molecular probe N,N'-5-diindole-2,6-pyridinedicarboxamide with a yield of 72%.

[0036] In this experiment, the structure of the ultraviolet fluorescent molecular probe N,N'-5-diindole-2,6-pyridinedicarboxamide was characterized by H-NMR, C-NMR and high-resolution mass spectrometry.

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Abstract

The invention relates to a synthesis method of an ultraviolet fluorescence molecule probe N,N'-5-diindole-2,6-pyridinedicarboxamide, and an application of the probe in detection of nitrite ions in various practical samples. Synthesis of a double-arm cave-shaped compound adopting bisindole as a fluorescence group and pyridinedicarboxamide as a support realizes specific identification of the nitrite ions. The probe has the characteristics of stable optical properties, good specificity, high sensitivity, easiness in preparation, and low cost, and can detect the nitrite ions under a mild pH value (2-5) condition. When the N,N'-5-diindole-2,6-pyridinedicarboxamide is used to detect the content of the nitrite ions in the various practical samples, the existence or not of the nitrites in a sample can be qualitatively judged according to the color change, and the content of the nitrite ions in the sample can be detected through ultraviolet fluorescence spectrum.

Description

technical field [0001] The invention relates to the synthesis of an ultraviolet fluorescent molecular probe N,N'-5-diindole-2,6-pyridinedicarboxamide and its detection of nitrite, belonging to the field of organic light-emitting materials. Background technique [0002] Nitrite mainly refers to sodium nitrite (NaNO 2 ) and potassium nitrite (KNO 2 ), which is white or slightly yellow crystal or granular powder, known as industrial table salt. Nitrite is widely distributed in nature and is one of the most widely distributed nitrogen-containing compounds in nature. Since nitrite easily interacts with proteins in the human body to form carcinogenic N-nitrosamine compounds, excessive intake of nitrite Salt can easily lead to many diseases, such as: esophageal cancer, methemoglobinemia in infants, spontaneous abortion and birth defects of the central nervous system and other diseases. Therefore, the determination of nitrite content is particularly important in water quality mon...

Claims

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Application Information

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IPC IPC(8): G01N21/78G01N21/64G01N21/33C07D401/14C09K11/06
CPCC07D401/14C09K11/06C09K2211/1029G01N21/33G01N21/643G01N21/78G01N2021/6432
Inventor 张海霞张逢源焦志娟
Owner LANZHOU UNIVERSITY
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