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Graphene micron fibers and preparation method thereof, nerve tissue scaffold, and repair system

A technology of micron fiber and nerve tissue, applied in the field of nerve repair system, can solve the problems of acceleration and lack of nerve repair materials, etc., and achieve high conductivity, good cell compatibility, and good adhesion effect

Active Publication Date: 2017-04-26
BEIJING INST OF NANOENERGY & NANOSYST
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the reported nerve repair strategies lack an ideal nerve repair material, which can provide the best biological and physical and chemical microenvironment for nerve regeneration, and achieve the purpose of accelerating nerve repair.

Method used

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  • Graphene micron fibers and preparation method thereof, nerve tissue scaffold, and repair system
  • Graphene micron fibers and preparation method thereof, nerve tissue scaffold, and repair system
  • Graphene micron fibers and preparation method thereof, nerve tissue scaffold, and repair system

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preparation example Construction

[0055] Another aspect of the present invention provides a method for preparing the aforementioned modified microfibers, which includes: taking a mixed solution containing polyethylenedioxythiophene and graphene oxide and subjecting it to hydrothermal treatment to obtain the modified microfibers.

[0056] In a preferred version, the solution contains graphene oxide at a concentration of 5 mg / ml to 10 mg / ml, polyethylenedioxythiophene with a content of 0.1 wt % to 2 wt % of the graphene oxide content and the Graphene oxide has a good solubility in ultrapure water.

[0057] Further, the modified reduced graphene oxide microfibers are prepared from a mixed aqueous solution containing graphene oxide and polyethylenedioxythiophene in a capillary long glass tube after high-temperature hydrothermal reaction treatment.

[0058] The inventors of this case found through a large number of experiments that when the inner diameter of the elongated capillary glass tube is between 0.4mm and 1...

Embodiment

[0065] First, configure the graphene oxide mixed solution doped with polyethylenedioxythiophene to prepare two graphene oxide solutions with a concentration of 5 mg / ml: take two parts of 500 mg graphene oxide powder with an electronic analytical balance, and dissolve them in two parts respectively. 10ml ultrapure water, set aside.

[0066] Prepare two graphene oxide solutions with a concentration of 8 mg / ml: take 800 mg of graphene oxide powder with an electronic analytical balance, dissolve them in two parts of 10 ml ultrapure water, and set aside.

[0067] Take 5 mg and 8 mg of polyethylenedioxythiophene powder with an electronic balance, add them to a prepared graphene oxide solution of 5 mg / ml and 8 mg / ml respectively, and shake and mix.

[0068] As above, four solutions were prepared, two were graphene oxide solutions without polyethylenedioxythiophene powder, and two were mixed solutions with 5 mg and 8 mg polyethylenedioxythiophene powder added respectively.

[0069] T...

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Abstract

The present invention provides modified and reduced graphene oxide micron fibers and a preparation method thereof, a nerve tissue scaffold and a self-driving nerve repair system. The micron fibers comprise reduced graphene oxide and an electric conduction macromolecule polymer poly(3,4-ethylenedioxythiophene), are continuous, and have a regular surface porous nanometer structure. The modified and reduced graphene oxide micron fiber preparation method comprises: preparing a poly(3,4-ethylenedioxythiophene) doped graphene oxide mixing solution, and preparing the modified and reduced graphene oxide micron fibers by using the solution. The nerve tissue scaffold comprises the modified and reduced graphene oxide micron fibers. The self-driving nerve repair system comprises the nerve tissue scaffold and a self-driving separate type friction nanometer power generator. According to the present invention, the micron fibers have characteristics of good shape, good surface appearance and good electrical conductivity, provide good adhesion and proliferation ability to bone marrow mesenchymal stem cells, and promote the neural differentiation of bone marrow mesenchymal stem cells.

Description

technical field [0001] The present invention relates to the field of nerve tissue scaffolds, in particular to artificial reduced graphene oxide microfibers used as nerve fibers, a preparation method thereof, a nerve tissue scaffold comprising the above-mentioned reduced graphene oxide microfibers, and a nerve repair system comprising the nerve tissue scaffolds . Background technique [0002] Nerve injury is one of the common and frequently occurring injury types in clinical practice. In my country alone, there are nearly one million new cases of nerve injury each year. With the continuous development of science and technology, nerve injury repair materials have been continuously improved and improved. So far, the main ways to repair nerve damage are: (1) perform surgery on short nerve defects, suture the damaged nerve, and then heal itself; (2) replace longer damaged nerves with substitute grafts; (3) Inject neurotrophic factors or add physical therapy. [0003] Implantab...

Claims

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Application Information

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IPC IPC(8): D01F6/94D01F1/09A61L27/08A61L27/18
CPCA61L27/08A61L27/18A61L2430/32D01F1/09D01F6/94C08L65/00
Inventor 郭伟博刘宏
Owner BEIJING INST OF NANOENERGY & NANOSYST
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