A kind of multi-substituted fused aromatic hydrocarbon derivative and its preparation method
A multi-substitution and derivative technology, which is applied in the field of multi-substitution fused aromatic hydrocarbon derivatives and its preparation, can solve difficult addition and oxidation problems, and achieve short reaction time, high efficiency, complex and diverse structures
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[0033] A multi-substituted fused aromatic hydrocarbon derivative, its structural formula is:
[0034]
[0035] A method for preparing polysubstituted fused aromatic hydrocarbon derivatives, comprising the following steps:
[0036] (1) With 830mmol sodium hydride as a catalyst, 200mmol dimethyl malonate and 440mmol propargyl bromide were added to 210mL anhydrous acetonitrile in an ice-water bath, stirred and reacted for 8 hours, the product was washed with water, extracted with ethyl acetate, and Press and spin dry to obtain a brownish-yellow solid product, i.e. compound 1
[0037] (2) Mix 80mmol compound 1 with 200mmol phenylethynyl bromide in Pd(PPh 3 ) 2 Cl 2 / CuI(2.56mmol / 0.85mmol) anhydrous and oxygen-free catalytic system, the molar ratio of Pd(PPh 3 ) 2 Cl 2 : CuI=3:1, with 336mmol triethylamine as base, 150mL anhydrous acetonitrile as solvent, stirring and reacting at room temperature for 12 hours, the product was washed with water, extracted with ethyl aceta...
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