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Degradable medicine slow release function composite enteric stent and making method thereof

A production method and functional technology, applied in the field of medical devices, can solve the problems of stent slippage, intestinal perforation, bleeding, inability to achieve the effect of treatment, endangering the life safety of patients, etc., and achieve a stable and efficient production method. The effect of promotion, excellent biocompatibility

Inactive Publication Date: 2017-04-26
SUZHOU UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the traditional metal stent can only support the intestinal tract and relieve the patient's obstruction, and cannot achieve the therapeutic effect
On the one hand, during the period of metal stent implantation in patients, related complications such as stent slippage, intestinal perforation, and bleeding are prone to occur, which increases the suffering of patients; on the other hand, patients need to take additional oral or Intramuscular injection of chemotherapy drugs, however, the effective concentration of the drug actually reaches the tumor site is low, and it is easy to cause related immune rejection, such as hair loss, vomiting, decreased immunity and liver and kidney function damage, which seriously endanger the life safety of patients

Method used

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  • Degradable medicine slow release function composite enteric stent and making method thereof
  • Degradable medicine slow release function composite enteric stent and making method thereof
  • Degradable medicine slow release function composite enteric stent and making method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0035] Inner tubular stent: The radial force is 0.3-3cN / mm prepared by the weft knitting method, the tube wall is smooth, and the tubular stent has good resilience. The selected scaffold material is polydioxanone (PDO), which has high strength (tensile strength ≥ 400N / mm2, breaking strength ≥ 600MPa), high elastic modulus, and a single filament diameter of about 0.2mm. The model of the selected knitting machine is No. 27 small-diameter circular weft loom, and the process parameters: the diameter of the needle cylinder is 30mm, 27 needles, the yarn tension is 2.1Kgf, the fabric tension is 150cN, the bending triangle is 3mm, and the knitting speed is 3m / minute. The parameters of the prepared inner tubular stent: transverse density 20 longitudinal rows / 5cm, longitudinal density 21 rows / 5cm, coil length 6mm, total density 1200 coils / 25cm 2, fiber volume content 15%, underfill coefficient 15. Thereafter, the inner tubular stent is decontaminated, cleaned, and heat-set.

[0036]...

Embodiment 2

[0039] Inner tubular stent: The radial force is 0.3-3cN / mm prepared by braiding, the tube wall is smooth, and the tubular stent has good resilience. The selected scaffold material is PLGA monofilament, which has a large elastic modulus and a diameter of about 0.3mm. The model of the selected knitting machine is No. 27 small-diameter circular weft loom, and the process parameters: the diameter of the needle cylinder is 30mm, 27 needles, the yarn tension is 2.1Kgf, the fabric tension is 150cN, the bending triangle is 3mm, and the knitting speed is 3m / minute. Prepared bare stent, parameters: horizontal density 20 longitudinal rows / 5cm, vertical density 21 rows / 5cm, coil length 6mm, total density 1200 coils / 25cm 2 , fiber volume content 15%, underfill coefficient 15. Thereafter, the inner tubular stent is decontaminated, cleaned and shaped.

[0040] Outer drug film layer: pure silk fibroin solution (mass fraction is 15%), 5-fluorouracil (concentration is 15mg / ml), curcumin (co...

Embodiment 3

[0043] Inner tubular stent: The tubular stent with a radial force of 0.3-3cN / mm, smooth tube wall and good resilience is prepared by knitting. The selected scaffold material is PGA, which has a large elastic modulus and a single filament diameter of about 0.4mm. The model of the selected knitting machine is No. 27 small-diameter circular weft loom, and the process parameters: the diameter of the needle cylinder is 30mm, 27 needles, the yarn tension is 2.1Kgf, the fabric tension is 150cN, the bending triangle is 3mm, and the knitting speed is 3m / minute. The parameters of the prepared inner tubular stent: transverse density 20 longitudinal rows / 5cm, longitudinal density 21 rows / 5cm, coil length 6mm, total density 1200 coils / 25cm 2 , fiber volume content 15%, underfill coefficient 15. Thereafter, the inner tubular stent is decontaminated, cleaned, and heat-set.

[0044] Outer drug film layer: adopt silk fibroin solution drug loading and drying film forming process to obtain 5...

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Abstract

The invention discloses a degradable medicine slow release function composite enteric stent. The degradable medicine slow release function composite enteric stent comprises an inner layer tubular stent and an outer layer medicine film, the inner layer tubular stent is a degradable tubular stent with a three-dimensional textile structure and has good flexibility and supporting performance, the textile structure is a weft-knitted structure or a braided structure, and yarns are mutually nested through a coil or are braided according to a certain braiding rule in order to form the tubular stent with stable structure and stable mechanical performances; and the outer layer medicine film is a fibroin protein solution medicine loaded coating, and the external surface of the textile structure is coated or laminated with the outer layer medicine film. The invention also discloses a making method of the enteric stent. The stent can support pathologic intestinal tracts, alleviate patients' intestinal obstruction and recovers patients' normal defecation; and the surface applied to the intestinal obstruction position is loaded with an antitumor medicine in order to realize a targeting therapy effect.

Description

technical field [0001] The invention belongs to the field of medical devices, and in particular relates to a compound intestinal stent with degradable drug sustained release function. Background technique [0002] Colorectal cancer, referred to as "CRC", is one of the diseases with the highest morbidity and mortality in the world today. Surgery is the most common method used to treat this condition, such as removal of the tumor, enterostomy, or open laparotomy. However, the recurrence rate and mortality rate caused by surgery are as high as 4%-60%, 8.8%-27%, and seriously affect the quality of life of patients. In addition, some advanced patients or elderly patients whose physical conditions are difficult to meet the surgical conditions cannot undergo surgery in time. Based on this, researchers have developed intestinal stents to relieve intestinal obstruction of patients, restore the patient's defecation function, and achieve the effect of palliative treatment. [0003] ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/22A61L27/18A61L27/54A61L27/50A61F2/90A61M31/00
CPCA61L27/18A61L27/227A61L27/50A61L27/54A61M31/00A61F2/90A61F2240/001A61F2210/0004A61L2430/22C08L89/00C08L67/04C08L69/00
Inventor 李刚谢旭升兰平赵泽宇孙慧何小文李翼
Owner SUZHOU UNIV
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