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Traditional Chinese medicinal extract for treating migraine, and preparation method and application thereof

A technology of extracts and traditional Chinese medicines, applied in the field of traditional Chinese medicine extracts for the treatment of migraine, can solve problems such as unfavorable therapeutic effects, unknown side effects, and influence on drug efficacy, and achieve the effects of reducing blood viscosity, no toxic side effects, and outstanding therapeutic effects

Inactive Publication Date: 2017-03-29
许启太
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, on the one hand, the direct use of traditional Chinese medicine raw materials leads to more complicated processing. More importantly, other unknown ingredients contained in the medicinal materials may affect the efficacy of the medicine and even cause unknown side effects, which is not conducive to the therapeutic effect.

Method used

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  • Traditional Chinese medicinal extract for treating migraine, and preparation method and application thereof
  • Traditional Chinese medicinal extract for treating migraine, and preparation method and application thereof

Examples

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Effect test

preparation example Construction

[0027] 1. Preparation of standard solution

[0028] Accurately weigh about 25mg of glucose dried to constant weight at 105°C, place it in a 250mL volumetric flask, add water to dissolve it, adjust the volume to the mark with water, shake well, and the glucose concentration in the prepared standard solution is about 0.1mg / mL.

[0029] 2. Preparation of Chinese medicine extract (test sample) solution

[0030] Take about 50 mg of the test sample, weigh it accurately, add 40 mL of water to dissolve, quantitatively transfer to a 250 mL volumetric flask, and add water to dilute to the mark.

[0031] 3. Measurement method

[0032] 3.1 Determination of standard curve

[0033] Precisely measure 0.2mL, 0.4mL, 0.6mL, 0.8mL, 1.0mL of the reference substance solution, put them into stoppered test tubes respectively, and add water to make up to 2.0mL;

[0034] Add 1mL of 5% phenol solution to each solution, shake well, quickly and precisely add 5mL of sulfuric acid, shake well, let it st...

Embodiment 1

[0069] The Chinese medicine extract described in the present embodiment is extracted according to the following steps:

[0070] (1) Squeeze extraction: sort the fresh betel nuts, clean them, crush them, and squeeze them with physical methods at 50°C to obtain fruit juices. The juices are processed to obtain clarified juices, and the residues are combined for later use;

[0071] (2) Residue extraction: Add 5 times the weight of the residue in water to the collected residue and mix evenly, add 0.1wt% low-temperature cellulase that accounts for the weight percentage of the residue for biolysis, and add hydrochloric acid to adjust the pH of the reaction solution Value 5, after standing for 8 hours, centrifuged at 10000rpm to obtain extract;

[0072] (3) Dehydration: Combine the extract obtained in step (2) and the fruit juice obtained in step (1), dehydrate by low-temperature decompression concentration, obtain solids, and pass through 60 meshes to pulverize, test, and obtain the ...

Embodiment 2

[0075] The Chinese medicine extract described in the present embodiment is extracted according to the following steps:

[0076] (1) Squeeze extraction: sort the fresh betel nuts, clean them, crush them, and squeeze them by physical methods at 20°C to obtain fruit juices. The juices are processed to obtain clarified juices, and the residues are combined for later use;

[0077] (2) Residue extraction: Add 3 times the weight of the residue to the collected residue and mix well, add 0.05wt% low-temperature cellulase that accounts for the weight percentage of the residue for biolysis, and add hydrochloric acid to adjust the pH of the reaction solution value 2, after standing for 12 hours, centrifuged at 6000rpm to obtain the extract;

[0078] (3) Dehydration: Combine step (2) obtained extract and step (1) obtained fruit juice, adopt the low-temperature decompression concentration mode to carry out dehydration, obtain solid matter, and cross 30-120 order pulverization, check, prompt...

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PUM

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Abstract

The invention belongs to the technical field of natural extracts, particularly relates to a traditional Chinese medicinal extract, and further discloses an extracting method and application thereof in preparation of a medicine for treating migraine. The traditional Chinese medicinal extract disclosed by the invention contains at least 15 weight percent of total polysaccharides and total polyphenols; the obtained extract has clear active ingredients, has a remarkable pain easing effect and has the advantages of safety, no toxic or side effect and the like, and can effectively relieve and treat symptoms of the migraine. Meanwhile, pain easing medicines of different preparations are prepared by utilizing the extract with the clear active ingredients, so that the pain easing medicines are conveniently taken by a patient, and the treatment effect is outstanding.

Description

technical field [0001] The invention belongs to the technical field of natural extracts, specifically relates to a traditional Chinese medicine extract for treating migraine, and further discloses a preparation method thereof. Background technique [0002] Betel nut is the seed of areca catechu (Areca catechu L.), a palm plant. It is a precious tropical plant in Hainan. my country's betel nuts are mainly distributed in Hainan and Taiwan provinces. At present, Hainan's betel nut planting area and output account for 98% of mainland my country. Betel nut is the second largest pillar industry in tropical crops in Hainan Province after the natural rubber industry, and is hailed as "emerald" by local farmers. Betel nut chewing is a traditional food custom with a history of more than two thousand years. Chinese people are used to chewing betel nut fresh fruit (Hainan, Taiwan) and dried fruit processed products (other regions in China), while India and Southeast Asia mainly chew be...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/889A61P25/06
CPCA61K36/889A61K2236/19A61K2236/31
Inventor 许启太
Owner 许启太
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