A kind of compound oral solution of potassium guaiacol sulfonate and preparation method thereof
A technology of potassium guaiacol sulfonate and oral solution, which is applied in the directions of pharmaceutical formulation, dispersion liquid delivery, anhydride/acid/halide active ingredients, etc., can solve problems such as easy crystallization, influence on drug use, drug instability, etc. , to prevent oxidation
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Embodiment 1
[0024] Preparation:
[0025] (a) dissolving the xylitol of formula quantity in the purified water that has boiled 15~20min;
[0026] (b) adding sodium citrate, citric acid, ammonium chloride, and potassium guaiacolsulfonate in the formula amount to the solution obtained in step (a) in sequence;
[0027] (c) The benzoic acid of formula quantity is completely dissolved in 50mL propylene glycol, after the solution that generates is added in the solution of step (b) gained, lemon essence is added step (b) gained solution;
[0028] (d) join the antioxidant, promethazine hydrochloride of formula quantity in the solution of step (c) gained;
[0029] (e) Add purified water and propylene glycol to the formula amount to the solution obtained in step (d), adjust the pH of the solution to 5.0-6.0 with a pH regulator, stir evenly, filter, fill, and sterilize.
Embodiment 2
[0031] 1000mL oral solution contains the following ingredients:
[0032] Promethazine hydrochloride 0.9g, potassium guaiacol sulfonate 23g, ammonium chloride 9g, citric acid 4.2g, sodium citrate 0.7g, xylitol 0.5g, benzoic acid 1.0g, lemon essence 1.0mL, 0.01g of vitamin C, appropriate amount of sodium bicarbonate, 200mL of propylene glycol, and purified water as the rest.
[0033] Repeat the preparation method in Example 1, but the antioxidant is vitamin C, the pH regulator is sodium bicarbonate, and the pH value of the adjusted solution is 5.0.
Embodiment 3
[0035] 1000mL oral solution contains the following ingredients:
[0036] Promethazine hydrochloride 1.1g, potassium guaiacol sulfonate 26g, ammonium chloride 11g, citric acid 4.5g, sodium citrate 0.73g, xylitol 2.8g, benzoic acid 1.3g, lemon essence 1.4mL, 0.3g of vitamin C, appropriate amount of sodium bicarbonate, 100mL of propylene glycol, and purified water as the rest.
[0037] Repeat the preparation method in Example 1, but the antioxidant is vitamin C, the pH regulator is sodium bicarbonate, and the pH value of the adjusted solution is 6.0.
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