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A kind of soft capsule and preparation method thereof

A technology of soft capsules and capsule skins, which is applied in capsule delivery, pharmaceutical formulations, medical preparations of non-active ingredients, etc. It can solve problems such as easy shell cracking, capsule hardening, soft capsule hardening, etc., and reach the disintegration time limit Good effect of stability, maintaining elasticity and hardness, uniformity and stability

Active Publication Date: 2019-05-07
BY HEALTH CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] In order to solve the problem of soft capsule hardening and easy shell cracking, researchers have tried a variety of solutions, even if adding new plasticizers to the rubber formula or increasing the amount of plasticizers or using compound plasticizers will not work. Does not solve the problem of capsules hardening during storage

Method used

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  • A kind of soft capsule and preparation method thereof
  • A kind of soft capsule and preparation method thereof
  • A kind of soft capsule and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] Preparation and detection of embodiment 1 soft capsule

[0037] 1, the formula of this embodiment soybean lecithin soft capsule is as follows:

[0038] The content of table 1 embodiment 1 soft capsule and the formula of rubber

[0039] Contents (10% glycerol, added in 2:3:5)

rubber

Soy Lecithin: Soybean Oil: Glycerin = 89:1:10

Glycerin: Purified Water: Gelatin = 1:2:2

[0040] 2. The preparation process of the soft capsule is as follows (content glycerol is added at 2:3:5):

[0041] (1) The capsule skin is prepared in a chemical glue tank;

[0042] (2) Preparation of soft capsule contents:

[0043] 1) When the pressure in the batching tank is -0.05MPa, the temperature is 40°C, and the stirring speed is set to 65 rpm, add the soybean oil of the recipe amount into the batching tank, and add 20% of the recipe amount of glycerin while stirring. The stirring time was 5 minutes.

[0044] 2) After the stirring time is reached, open the lid of t...

Embodiment 2

[0056] Preparation and detection of embodiment 2 soft capsules

[0057] 1, the formula of this embodiment soybean lecithin soft capsule is as follows:

[0058]The content of table 3 embodiment 2 soft capsules and the formula of rubber

[0059] Contents (glycerol 4%, added 2:3:5)

rubber

Soy Lecithin: Soybean Oil: Glycerin = 95:1:4

Glycerin: Purified Water: Gelatin = 1:2:2

[0060] 2. The preparation process of the soft capsule is as follows (content glycerol is added at 2:3:5):

[0061] (1) The capsule skin is prepared in a chemical glue tank;

[0062] (2) Preparation of soft capsule contents:

[0063] 1) When the pressure in the batching tank is -0.05MPa, the temperature is 40°C, and the stirring speed is set to 65 rpm, add the soybean oil of the recipe amount into the batching tank, and add 20% of the recipe amount of glycerin while stirring. The stirring time was 5 minutes.

[0064] 2) After the stirring time is reached, open the lid of the b...

Embodiment 3

[0077] Preparation and detection of embodiment 3 soft capsules

[0078] 1, the formula of this embodiment soybean lecithin soft capsule is as follows:

[0079] The content of table 5 embodiment 3 soft capsules and the prescription of rubber

[0080] Contents (15% glycerol, added 2:3:5)

rubber

Soy Lecithin: Soybean Oil: Glycerin = 84:1:15

Glycerin: Purified Water: Gelatin = 1:2:2

[0081] 2. The preparation process of the soft capsule is as follows (content glycerol is added at 2:3:5):

[0082] (1) The capsule skin is prepared in a chemical glue tank;

[0083] (2) Preparation of soft capsule contents:

[0084] 1) When the pressure in the batching tank is -0.05MPa, the temperature is 40°C, and the stirring speed is set to 65 rpm, add the soybean oil of the recipe amount into the batching tank, and add 20% of the recipe amount of glycerin while stirring. The stirring time was 5 minutes.

[0085] 2) After the stirring time is reached, open the lid ...

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Abstract

The invention relates to the technical field of preparations, in particular to a soft capsule and a preparation method thereof. The soft capsule comprises contents and a capsule shell, wherein the contents comprise an effective active ingredient, glycerin and a solvent. Glycerin in a specific ratio is added to the contents of the soft capsule, the elasticity and the hardness of the soft capsule shell can be effectively maintained, and the controllability purpose is achieved.

Description

technical field [0001] The invention relates to the technical field of preparations, in particular to a soft capsule and a preparation method thereof. Background technique [0002] Capsules in medicine and health food refer to capsules made of special film-forming materials (such as gelatin, cellulose, polysaccharides, etc.), and the contents (such as powder, liquid, etc.) or packed in doses into it, easy to swallow. In the field of preparation technology, powders or granules that are generally irritating to the esophagus and gastric mucosa, or drugs that have a bad taste, are easy to volatilize, are easily decomposed by saliva in the mouth, and are easy to be inhaled into the trachea need to be packed into capsules. The medicinal properties of the medicine are not destroyed, and the digestive organs and respiratory tract are also protected. Removing the capsule shell may result in drug loss, drug waste, and reduced drug efficacy. In addition, some drugs need to be dissol...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/48A61K47/10A61K31/685A61K35/50A61K36/48A61K36/488A61K35/644A61K35/65A23P10/30A23L29/00
CPCA23V2002/00A61K9/4808A61K9/4858A61K31/685A61K35/50A61K35/644A61K35/65A61K36/48A61K36/488A61K2300/00A23V2250/6406
Inventor 黄仪友李太适李泽其刘莉
Owner BY HEALTH CO LTD
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