Injectable in-situ gel capable of replacing surgical catgut for acupuncture and moxibustion embedding

A technology of in-situ gel and catgut, which is applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, organic active ingredients, etc., can solve the problems of limited toxic and side effects, low bioavailability, etc.

Inactive Publication Date: 2017-03-22
贵州中医药大学
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, tablets and injections are mainly on the market, because of their low bioavailability and toxic side effects limit their clinical application

Method used

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  • Injectable in-situ gel capable of replacing surgical catgut for acupuncture and moxibustion embedding
  • Injectable in-situ gel capable of replacing surgical catgut for acupuncture and moxibustion embedding
  • Injectable in-situ gel capable of replacing surgical catgut for acupuncture and moxibustion embedding

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0117] Composition: PLGA 30g, HMPC 2g, PEG400 10g and NMP 54g.

[0118] Process: After mixing PEG400 and NMP, add HPMC, after complete mixing, add PLGA, vortex shake for 24 hours, sterilize with Co60, and store in the dark at 4°C to obtain the product.

[0119] Usage and dosage: acupoint injection; dosage: 16mg once for adults; dosing interval: once a week.

Embodiment 2

[0121] Composition: PLGA 45g, HMPC 3g, PEG400 20g and NMP 65g.

[0122] Process: After mixing PEG400 and NMP, add HPMC, after complete mixing, add PLGA, vortex for 28 hours, sterilize with Co60, and store in the dark at 4°C to obtain the product.

[0123] Usage and dosage are the same as in Example 1.

Embodiment 3

[0125] Composition: PLGA 15g, HMPC 1g, PEG400 1g and NMP 40g.

[0126] Process: After mixing PEG400 and NMP, add HPMC, and after mixing completely, add PLGA, vortex for 20 hours, sterilize with Co60, and store in the dark at 4°C.

[0127] Usage and dosage are the same as in Example 1.

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Abstract

The invention discloses injectable in-situ gel capable of replacing a surgical catgut for acupuncture and moxibustion embedding. The injectable in-situ gel is mainly prepared from PLGA, HMPC, PEG400, NMP and alpha-asarin or ephedrine. The injectable in-situ gel is good in fluidity, curing forming performance and release degree and high in bioavailability. Meanwhile, the injectable in-situ gel has a good anti-asthma treatment effect, can be used for acupoint injection treatment on asthma and can replace surgical catgut for acupuncture and moxibustion embedding in treatment.

Description

technical field [0001] The invention relates to an injectable in-situ gel for replacing catgut for acupuncture and moxibustion implantation, and belongs to the technical field of medicines or medical devices. [0002] technical background [0003] Injectable in situ gel (in situ gel) sustained-release drug delivery system is a research hotspot in the field of sustained-control injections in recent years. A phase transition occurs to form a non-chemically cross-linked semi-solid formulation. The water-soluble in-situ thermosensitive gel is formed through the polymer solution changing with the temperature, and the viscosity changes abruptly to form a hydrophilic three-dimensional network structure with a gel preparation, which has good tissue compatibility. Such injectable polymer gels are degraded in vivo to small, nontoxic molecules. At the same time, the unique solution-gel phase transition properties make the in situ gel have the advantages of simple preparation, convenie...

Claims

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Application Information

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IPC IPC(8): A61K9/06A61K47/34A61K47/38A61K47/22A61K31/09A61K31/137A61P11/06
CPCA61K9/0024A61K9/06A61K31/09A61K31/137A61K47/22A61K47/34A61K47/38
Inventor 张永萍徐剑迮薇薇代传洋谢伟杰
Owner 贵州中医药大学
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