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Traditional Chinese medicine composition for preparing antidiabetic nephropathy product and preparation method and application of traditional Chinese medicine composition

A technology for diabetic nephropathy and anti-diabetes, which is applied in the field of traditional Chinese medicine prescriptions for the preparation of anti-diabetic nephropathy products and its preparation and use, can solve the problems of progressive aggravation, abnormal metabolism, abnormal metabolism of vasoactive substances, etc., and achieve economic relief. Pressure, simple preparation process, and the effect of improving the quality of life

Active Publication Date: 2017-03-15
曲晓璐
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0013] 2. Fatigue, obesity
[0019] 2. Urine sugar
[0132] ③Acute cerebrovascular disease mainly manifests as cerebral thrombosis, mostly small and medium arterial infarction and multiple lesions, the clinical symptoms are often mild, but often recurrent, progressive aggravation, difficult recovery
[0200] 2. Abnormal renal hemodynamics
[0202] 3. Metabolic abnormalities caused by high blood sugar
[0206] 5. Abnormal metabolism of vasoactive substances
[0213] 3. Anemia
[0330] Through literature search, so far, no other new and more effective traditional Chinese medicine prescriptions for the prevention, treatment and research of diabetic nephropathy have been found.

Method used

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  • Traditional Chinese medicine composition for preparing antidiabetic nephropathy product and preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for preparing antidiabetic nephropathy product and preparation method and application of traditional Chinese medicine composition
  • Traditional Chinese medicine composition for preparing antidiabetic nephropathy product and preparation method and application of traditional Chinese medicine composition

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Experimental program
Comparison scheme
Effect test

preparation example Construction

[0414] In order to further set forth the preparation method of the present invention, further set forth below:

[0415] The preparation method of the traditional Chinese medicine prescription of the present invention is to take the raw materials of Chinese medicinal materials in parts by weight, and prepare by water extraction and alcohol precipitation to obtain the Chinese medicine extract, extract or dry powder. The preparation method is as follows:

[0416] (1) Weigh 3-6kg of astragalus, 3-6kg of Rehmannia glutinosa, 1.5-3kg of dogwood, 1-2kg of dodder, 1-2kg of Puhuang, 3-6kg of salvia miltiorrhiza, 1.5-3kg of ghost arrow feather, 3-6kg of berberine, corn Mustard 3-6kg, Achyranthes bidentata 1.5-3kg, combine all medicinal materials;

[0417] (2) Add water to decoct 2 to 3 times, each time adding water is 10 to 15 times the total weight of medicinal materials, decoct for 1 to 3 hours, and combine the decoction;

[0418] (3) Concentrate under reduced pressure under the cond...

Embodiment 1

[0423] Embodiment 1, the preparation of Chinese medicine extract

[0424] Weigh astragalus 3kg, rehmannia glutinosa 3kg, dogwood 1.5kg, dodder 1kg, puhuang 1kg, salvia miltiorrhiza 3kg, ghost arrow feather 1.5kg, coptis 3kg, corn silk 3kg, achyranthes bidentata 1.5kg. Combine all the medicinal materials, add water to decoct twice, add water for the first time to 12 times the total weight of the medicinal materials, decoct for 2 hours, add water for the second time to 10 times the total weight of the medicinal materials, decoct for 1.5 hours, combine the decoction, Under the condition of 0.08MPa and concentrated under reduced pressure to 65°C, the relative density is 1.15, add 95% (v / v) ethanol to make the alcohol content reach 85% (v / v), stir, stand overnight, filter, and the filtrate is in Concentrate under reduced pressure at 0.08MPa to recover ethanol, and continue to concentrate to a thick paste, dry, pulverize and pass through a 100-mesh sieve to obtain dry powder of the ...

Embodiment 2

[0425] Example 2, the curative effect evaluation experiment of Shenqi No. 1

[0426] Efficacy evaluation of "Shenqi Ⅰ" in the treatment of early and middle stage diabetic nephropathy (DNⅢ-Ⅳ stage)

[0427] 1. Source of cases: 80 DN cases met the inclusion criteria in outpatient or inpatient departments of Traditional Chinese Medicine and Nephrology in Punan Hospital from 2014 to 2015.

[0428] 2. Western medicine diagnostic criteria:

[0429] 2.1 According to the type 2 diabetes standard established by ADA (American Diabetes Association) in 2010: glycosylated hemoglobin Alc≥6.5% or fasting blood glucose FPG≥7.0mmol / l (fasting is defined as no calorie intake for at least 8 hours) or oral glucose tolerance test 2h blood glucose ≥ 11.1mmol / l, or in patients with typical symptoms of hyperglycemia, random blood glucose ≥ 11.1mmol / l.

[0430] 2.2 According to the Mogensen staging criteria, patients with early and mid-stage DN who meet stage II-IV:

[0431] Stage II: normal albumi...

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Abstract

The invention relates to the technical field of medicine, and discloses a traditional Chinese medicine composition for preparing an antidiabetic nephropathy product kidney-milkvetch root No.1 and a preparation method and application of the traditional Chinese medicine composition. The kidney-milkvetch root No.1 is prepared from milkvetch roots, prepared rehmannia roots, fructus corni, semen cuscutae, pollen typhae, radix salviae miltiorrhizae, ramuli euonymi, rhizoma coptidis, corn stigmas and radix achyranthis bidentatae; the effect of treating qi-yin deficiency blood stasis type diabetic nephropathy is significant, and the proteinuria content of an early-middle-stage diabetic nephropathy patient can be decreased; in the aspect of protecting the residual renal function, clinical random control study shows that the marked effective rate is 62.1%, the effective rate is 24.1%, and the total effective rate is 86.2%. The traditional Chinese medicine composition is wide in raw material source, low in cost, simple in preparation technology, high in yield and stable in property; a preparation prepared from the traditional Chinese medicine composition is stable in quality, capable of achieving easy and convenient quality control, low in production cost, capable of conveniently achieving industrialized production, safe, low in toxicity and convenient to use and provides a new medicine source and safe raw material for prevention, treatment and research of antidiabetic nephropathy and direct related diseases thereof.

Description

technical field [0001] The present invention relates to the technical fields of medicine, food, beverage, etc., in particular to a product for the prevention, treatment and research of diabetic nephropathy and related diseases directly caused by it, its preparation method and application, more specifically to A traditional Chinese medicine prescription mainly used for preventing, treating and researching diabetic nephropathy of deficiency of both qi and yin and blood stasis (or called diabetic nephrotic syndrome of deficiency of both qi and yin and blood stasis) and related diseases directly caused by it and its preparation method and uses. Background technique [0002] 1. Diabetes [0003] Diabetes mellitus (DM for short) is a group of metabolic diseases characterized by hyperglycemia. Hyperglycemia is caused by defective insulin secretion or impaired biological action, or both. The long-term high blood sugar in diabetes leads to chronic damage and dysfunction of various...

Claims

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Application Information

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IPC IPC(8): A61K36/899A61P3/10A61P13/12A61P9/14A23L33/29
CPCA23V2002/00A61K36/21A61K36/37A61K36/39A61K36/40A61K36/43A61K36/481A61K36/537A61K36/718A61K36/804A61K36/88A61K36/899A61K2236/331A61K2236/51A61K2236/55A61K2300/00A23V2200/328
Inventor 曲晓璐李铁军管孝君庹焱
Owner 曲晓璐
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