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Quality Control Method of Taohe Chengqi Decoction Composition

A quality control method, the technology of Chengqi Decoction, applied in measuring devices, instruments, scientific instruments, etc., can solve the problems of few indicators, single quality control, and many medicinal flavors, and achieve the effects of objective conclusions, control of preparation quality, and convenient operation.

Active Publication Date: 2019-04-12
CHINA RESOURCES SANJIU MEDICAL & PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The technical problem to be solved by the present invention is to overcome that the traditional Chinese medicine compound preparation in the prior art basically has only one or two index components in content control, single quality control, few indicators, and it is difficult to fully reflect the many flavors of medicines, many components, and many targets. The defect of the quality status of the Taohe Chengqi Decoction composition, thereby providing the quality control method of the Taohe Chengqi Decoction composition

Method used

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  • Quality Control Method of Taohe Chengqi Decoction Composition
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  • Quality Control Method of Taohe Chengqi Decoction Composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0087] Example 1: Preparation of Taohe Chengqi Decoction Composition

[0088] The first Taohe Chengqi soup composition: Weigh the following decoction pieces by weight: 12g of peach kernels, 12g of rhubarb, 6g of roasted licorice, 6g of cinnamon sticks, 6g of Glauber's salt; Four-flavored pieces (except Glauber's salt) are placed in a 4L casserole, Add 1400ml of water, soak for 30 minutes, cover, use sogo heating plate as heating device, boil (about 25min), keep slightly boiling (about 85 minutes, evaporation of about 10g / min) to about 500ml of decoction, use two layers of medical Use gauze to filter out the medicine residue, add Glauber's salt, and boil it to get.

[0089] The second Taohe Chengqi Decoction composition: Weigh the following decoction pieces by weight: 1000g peach kernels, 1000g rhubarb, 500g cassia twigs, 500g glauber's salt, 500g licorice; four-flavor decoction pieces (except mirabilite), add 8 times the amount Decoction in water for 1.5h to obtain the filtrate; ...

Embodiment 2

[0090] Example 2. Determination of free anthraquinone content in Taohe Chengqi Decoction composition by HPLC

[0091] (1) Chromatographic conditions and system applicability

[0092] Use octadecylsilane-bonded silica gel as filler; use acetonitrile as mobile phase A and 0.1% phosphoric acid as mobile phase B, gradient elution; detection wavelength is 254nm. The number of theoretical plates should not be less than 3000 based on the emodin peak, flow rate: 1.0ml / min, column temperature: 30℃.

[0093] Gradient elution program

[0094]

[0095] (2) Preparation of reference solution

[0096] Accurately weigh aloe-emodin reference substance, rhein reference substance, emodin reference substance, chrysophanol reference substance, emodin methyl ether reference substance, and add methanol to make each 1ml containing aloe-emodin, rhein, emodin, A solution of 80μg each of chrysophanol and 40μg of emodin methyl ether; respectively accurately measure 2ml each of the above-mentioned reference solu...

Embodiment 3

[0111] Example 3. Determination of total anthraquinone content in Taohe Chengqi Decoction composition by HPLC

[0112] (1) Chromatographic conditions and system applicability

[0113] Use octadecylsilane-bonded silica gel as filler; use methanol as mobile phase A and 0.1% phosphoric acid as mobile phase B, gradient elution; detection wavelength is 254nm. The number of theoretical plates should not be less than 3000 based on the emodin peak, flow rate: 0.8ml / min, column temperature: 30℃.

[0114] Gradient elution program

[0115]

[0116] (2) Preparation of reference solution

[0117] Accurately weigh the appropriate amount of aloe-emodin reference substance, rhein reference substance, emodin reference substance, chrysophanol reference substance, and emodin methyl ether reference substance, and add methanol to make each 1ml containing aloe-emodin, rhein, emodin, A solution of 80μg each of chrysophanol and 40μg of emodin methyl ether; respectively accurately measure 2ml each of the abo...

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Abstract

The invention discloses a quality control method of a peach kernel qi activating decoction composition and belongs to the field of traditional Chinese medicine analysis. The method includes the steps that a peach kernel qi activating decoction fingerprint spectrum is established through high performance liquid chromatography, and chromatographic conditions are characterized in that a chromatographic column adopts octadecylsilane chemically bonded silica as filler; an ultraviolet detector is adopted as a detection instrument, and the detection wavelength of the fingerprint spectrum ranges from 210 nm to 250 nm; the flow rate ranges from 0.9 ml / ml to 1.1 ml / ml, the column temperature ranges from 25 DEG C to 35 DEG C, the detection wavelength ranges from 210 nm to 250 nm, the number of theoretical plates should not be smaller than 3,000 according to calculation of catechinic acid peaks, methyl alcohol serves as a moving phase A, a 0.1% phosphoric acid solution serves as a moving phase B, and gradient elution is carried out according to the following sequence: the gradient condition of elution detection of the fingerprint spectrum is defined in the specification. The fingerprint spectrum comprehensively reflects quality information of a peach kernel qi activating decoction, and therefore the quality of the peach kernel qi activating decoction can be more comprehensively and effectively controlled.

Description

Technical field [0001] The invention belongs to the field of traditional Chinese medicine analysis, and specifically relates to a quality control method of Taohe Chengqi Decoction composition. Background technique [0002] Traditional Chinese medicine decoction is the mainstream of clinical medicine. However, due to the inconvenience of decoction and carrying, the quality of decoction prepared by decoction often varies greatly depending on the person and the decoction equipment. The classic clinical curative effect of the decoction is accurate. The traditional Chinese medicine preparations that are convenient to carry and easy to take are developed by using modern science and technology to develop traditional Chinese medicine preparations that are convenient to carry and easy to take. It is not only the inheritance of traditional Chinese medicine, but also better promotes the classic famous prescriptions. Clinical application. The preparation process of granules is relatively si...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/06G01N30/60G01N30/74
CPCG01N30/06G01N30/6052G01N30/74
Inventor 陈世彬虢小翊陈周全刘志刚谭沛马鹏岗丁苗苗刘志东
Owner CHINA RESOURCES SANJIU MEDICAL & PHARMA
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