Compound fluconazole injection and preparation method thereof

Abstract

The invention discloses a compound fluconazole injection and a preparation method thereof, wherein the compound fluconazole injection comprises fluconazole, ivermectin and an organic solvent. According to the present invention, the preparation process is simple, and the proper ratio of the injection is determined through a large number of experiments, wherein per 1000 ml of the injection contains 5-100 g of fluconazole and 5-30 g of ivermectin; and the pet inside and outside parasite and fungal infection experiment results prove that the prepared injection has the stable quality, the treatment effect is significant, the cure rate can achieve 100%, and the defect of the use of the single reagent is overcome.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a compound fluconazole injection and a preparation method thereof, which can be used for preventing and treating internal and external parasites and fungal infections of pets. Background technique [0002] Parasites and fungal infections inside and outside pets are very common. Fungi, parasites and mixed infectious skin diseases of pet dogs and cats account for a considerable proportion of pet skin diseases in my country. Wu Qingbo’s investigation of pet skin disease pathogens in Baoding City shows that , the incidence rates of single parasitic infection, single fungal infection, single bacterial infection, and mixed infection accounted for 34.96%, 23.31%, 20.30%, and 18.42% of canine skin diseases respectively; the incidence rate of mite infection in parasitic skin diseases was 64.52%. % (60 / 93), with demodicosis occurring most (28 / 93), followed by ...

AI Technical Summary

Problems solved by technology

[0003] In addition, fungi and internal and external parasites are zoonotic diseases. Due to the closeness between pets and people, pets pose a great threat to people once they get sick. The probability of infecting people is high and the number is large.

According to a survey in the UK, 50% of people in contact with cats infected with Microsporum are infected with fungi, and 69% of families have at least one person infected, and pet fungal skin diseases are prone to relapse after treatment due to their long course of disease and repeated attacks , long-term oral administration has certain side effects, which has a great impact on the health of affected animals

[0004] At present, in the prior art, only the injection containing one of the ingredients is used alone, either to inhibit or kill parasites, or to inhibit or kill fungi, and cannot inhibit or kill parasites and fungi at the same time

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