Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Production process of sodium hyaluronate

A sodium hyaluronate and production process technology, applied in the direction of microorganisms, microorganisms, and methods based on microorganisms, can solve the problems that the activity of bacteria cannot be stimulated, the yield of hyaluronic acid is low, and the fermentation cycle is long. Short, low production cost, simple production process

Active Publication Date: 2017-02-22
DONGYING FIRST BIOCHEM IND CO LTD
View PDF3 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] The process of producing hyaluronic acid by microbial fermentation has a long fermentation cycle, and the fermentation process cannot be carried out according to the characteristics of the strain, resulting in the inability to stimulate the activity of the strain, low yield of hyaluronic acid, and poor product quality

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Examples

Experimental program
Comparison scheme
Effect test

Embodiment １

[0024] Streptococcus equi zooepidemic subspecies used in the present invention ( Streptococcus equi subsp. zooepidemicus ) DCS005. At present, this Streptococcus equi subspecies zooepidemicus is preserved in the General Microbiology Center of the China Microbiological Culture Collection Management Committee. .12782, the Latin name for the strain is Streptococcus equi subsp. zooepidemicus , The reference microorganism (strain): DCS005, the date of preservation is July 14, 2016.

[0025] A production process of sodium hyaluronate, comprising the following steps:

[0026] (1) Streptococcus equi subspecies zooepidemicus ( Streptococcus equi subsp. zooepidemicus ) DCS005 shake flask seed liquid culture, the culture conditions are: 38.5 ° C for 12-16 hours;

[0027] (2) Expanded culture of strains, the culture conditions are temperature 38.5°C, pH 7.0-7.3, culture time 12-16 hours, tank pressure 0.05MPa;

[0028] (3) Fermentation, after feeding sterile oxygen-containing air at 3...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention discloses a production process of sodium hyaluronate. A strain high in hyaluronic acid yield is screened out, improved fermentation technology is combined, production period is short, and the production process is simple; raw and auxiliary materials are common and easy to get, production is easy to control, impurity content is lower, the production process is suitable for industrial large-scale production requirements and high in yield, and production cost is lowered greatly.

Description

technical field [0001] The invention relates to the technical field of hyaluronic acid production, in particular to a production process of sodium hyaluronate. Background technique [0002] The process of producing hyaluronic acid by microbial fermentation has a long fermentation period, and the fermentation process cannot be carried out according to the characteristics of the strains, resulting in the inability to stimulate the activity of the strains, low yield of hyaluronic acid, and poor product quality. The fermentation broth contains substances such as bacteria, protein, and nucleic acid. The extraction of hyaluronic acid not only requires a high extraction rate and no depolymerization of its molecules, but also requires high product purity. The process of extracting hyaluronic acid from the fermentation broth It will directly affect the yield, quality and production cost of hyaluronic acid. [0003] It is a technical problem to be solved in the present invention to d...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): C12N1/20C12P19/26C12R1/46
CPCC12P19/26C12N1/205C12R2001/46
Inventor 巴奉良惠贤秋肖馗缨马骞寰牛玲晓
Owner DONGYING FIRST BIOCHEM IND CO LTD
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com