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Paclitaxel detoxified compound extract with anti-cancer effect and method for preparing paclitaxel detoxified compound extract

A technology of compound extract and paclitaxel, which is applied in the direction of medical preparations containing active ingredients, antineoplastic drugs, and pharmaceutical formulas, etc., can solve problems such as toxic and side effects, limit wide application and curative effect, and insignificant curative effect, and achieve the content of active ingredients High, significant curative effect, doubling the effect of active release

Inactive Publication Date: 2017-02-22
徐英奎
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] In recent years, Chinese medicine researchers at home and abroad have attached great importance to the research of new anti-cancer drugs. New methods such as combination and screening of chemistry and genetic engineering have been significantly improved with the research level of molecular biology and molecular pharmacology. Realizing that almost all anticancer drugs so far belong to the scope of cytotoxicity, this unavoidable side effect greatly limits its wide application and curative effect. With the transformation of modern cancer prevention and treatment to comprehensive treatment, traditional Traditional Chinese medicine has accumulated a wealth of clinical application experience in the prevention and treatment of tumors, and has a deeper understanding of the nature and mechanism of tumors, and the research level of anti-cancer compound drugs has continuously improved.
The Chinese invention patent application with the application number 201110426078.6 discloses a yew compound traditional Chinese medicine with anti-cancer effect and its preparation method. The prescription does not damage normal human cells and has no toxic and side effects, but the curative effect is not significant

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0029] (1) Cut 100g of fresh oriental alcohol S7 yew stems, branches and leaves into 2-3 cm long, rinse them, put them into a bamboo sieve, stir continuously in high-temperature steam, dry-fry and atomize until the branches and leaves shrink, soft, When the color is fresh, add vinegar and mix evenly, still soak at high temperature for 20 minutes, pour it into the bamboo sieve, spread it out and cool it for 4 hours, and store it at a stable 2°C for later use; the temperature of the high-temperature steam in the bamboo sieve is 250 °C; the temperature for high temperature humidification and infiltration is 300 °C.

[0030] (2) Take the spare fresh S7 yew stems, branches and leaves plus 20g of red rock soil, put them on an iron pan and stir-fry them with a slow fire for 15 minutes, then put them on a bluestone board to cool down to 50% heat, and add 100g of grass Mix the ginger liquid evenly until it is 1 times hotter in the shade, then add 100g of grass ginger liquid to detoxify...

Embodiment 2

[0035] (1) Cut 100g of fresh oriental alcohol S7 yew stems, branches and leaves into 2-3 cm long, rinse them, put them into a bamboo sieve, stir continuously in high-temperature steam, dry-fry and atomize until the branches and leaves shrink, soft, When the color is fresh, add vinegar and mix evenly, still soak at high temperature for 25 minutes, pour it into the bamboo sieve, spread it out and cool it for 5 hours, and store it at a stable 2°C for later use; the temperature of the high-temperature steam in the bamboo sieve is 280 ℃; the temperature for high temperature humidification and infiltration is 350 ℃.

[0036] (2) Take the spare fresh S7 yew stems, branches and leaves plus 200g of red rock soil, put them on an iron pan and stir-fry them with a slow fire for 12 minutes, then put them on a bluestone board to cool down to 60% heat, and add 120g of grass Mix the ginger liquid evenly until it is 2 times hotter in the shade, then add 30g of grass ginger liquid to detoxify t...

Embodiment 3

[0041] (1) Cut 100g of fresh oriental alcohol S7 yew stems, branches and leaves into 2-3 cm long, rinse them, put them into a bamboo sieve, stir continuously in high-temperature steam, dry-fry and atomize until the branches and leaves shrink, soft, When the color is fresh, add vinegar and mix evenly, still humidify and soak at high temperature for 15 minutes, pour it into the bamboo sieve, spread it out and cool it for 3 hours, and store it at a stable temperature of 0°C for later use; the temperature of the high-temperature steam in the bamboo sieve is 200 ℃; the temperature of high temperature humidification and infiltration is 280 ℃.

[0042] (2) Take the spare fresh S7 yew stems, branches and leaves plus 100g of red rock soil, put it on an iron pan and stir-fry for 12 minutes, then put it on a bluestone board to cool down to 50% heat, and put 80g of grass twice its weight Mix the ginger liquid evenly until it is 3 times hotter in the shade, then add 20g of grass ginger liq...

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Abstract

The invention discloses a paclitaxel detoxified compound extract with an anti-cancer effect and a method for preparing the paclitaxel detoxified compound extract, and relates to a compound traditional Chinese medicinal preparation and a method for preparing the compound traditional Chinese medicinal preparation. The method for preparing the paclitaxel detoxified compound extract comprises the following steps of making a stem, branches and leaves of fresh oriental alcohol S7 taxus chinensis into powder through dry frying, atomization, detoxification and leaching; taking and making cordyceps, scoparia dulcis, rhizoma dioscoreae, fructus lycii and vinegar into powder through single frying, single solarization and single airing; taking and making radix salviae miltiorrhizae, scolopendra, radix paeoniae alba, radix astragali seu hedysari, flos carthami and rhizoma smilacis glabrae into powder through processing; taking wild honey, adding vinegar into the wild honey, and then stirring the powder into an obtained mixture, so as to obtain the detoxified compound extract. According to the paclitaxel detoxified compound extract and the method, after the oriental alcohol S7 taxus chinensis is subjected to detoxification and refining, beneficial substances of flavone, alkaloid and the like in the oriental alcohol S7 taxus chinensis are all retained; further, the biological structures of effective components cannot be damaged; the content of multiple elements of paclitaxel and the like in a taxus-chinensis extract obtained through water dissolution and leaching can be up to 98.7 percent or above at most; the increment of a cancer cell can be effectively prevented and inhibited; the curative effect is obvious.

Description

technical field [0001] The invention relates to a compound traditional Chinese medicine preparation and a preparation method thereof, in particular to a paclitaxel detoxification compound extract material drug with anticancer effect and a preparation method thereof. Background technique [0002] In recent years, Chinese medicine researchers at home and abroad have attached great importance to the research of new anti-cancer drugs. New methods such as combination and screening of chemistry and genetic engineering have been significantly improved with the research level of molecular biology and molecular pharmacology. Realizing that almost all anticancer drugs so far belong to the scope of cytotoxicity, this unavoidable side effect greatly limits its wide application and curative effect. With the transformation of modern cancer prevention and treatment to comprehensive treatment, traditional Traditional Chinese medicine has accumulated a wealth of clinical application experien...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/90A61K36/896A61P35/00A61K35/648A61K35/644A61K31/19
CPCA61K36/90A61K31/19A61K35/644A61K35/648A61K36/068A61K36/13A61K36/286A61K36/481A61K36/537A61K36/65A61K36/71A61K36/80A61K36/815A61K36/8945A61K36/896A61K2236/10A61K2236/331A61K2300/00
Inventor 徐英奎
Owner 徐英奎
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