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A kind of Shuxuening injection and preparation method thereof

An injection and solution technology, applied in the field of Shuxuening injection and its preparation, can solve the problems of low extraction rate, achieve good solubility, improve product quality, and good stability

Active Publication Date: 2019-04-16
HEILONGJIANG ZBD PHARMA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is only extracted by soaking in ethanol, the extraction method is relatively simple, and the extraction rate is low

Method used

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  • A kind of Shuxuening injection and preparation method thereof
  • A kind of Shuxuening injection and preparation method thereof
  • A kind of Shuxuening injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Embodiment 1: Ginkgo biloba composition

[0034] 1. Extraction method

[0035] (1) Take ginkgo leaves and bake them at 65°C for 4 hours, ultrafinely pulverize them, soak them in 5 times of 55% ethanol for 1.5 hours at 50-60°C, extract them under reflux for 1 hour, collect the extract, and use 4 times of 55% ethanol for the filter residue. A mixed solvent composed of ethanol, glycerol and methylene chloride was refluxed for extraction for 1 hour, and the extract was collected; wherein, the volume ratio of 50-60% ethanol, glycerol and methylene chloride was 6:1:2.

[0036] (2) Combine the extracts, adjust the pH to 7.6 with NaOH solution, let stand for 18h, filter, add water to make the volume 5 times the volume of Ginkgo biloba;

[0037] (3) add concentrated hydrochloric acid to adjust pH to be 4.8, centrifuge at 4750r / min;

[0038] (4) The centrifuge passes through the macroporous adsorption resin column with 1.7BV / h; washes the resin with the flow rate of 3.5BV / h wit...

Embodiment 2

[0074] Embodiment 2: Ginkgo biloba composition

[0075] 1. Extraction method

[0076] (1) Get ginkgo leaf and dry at 60 DEG C for 3 hours, superfinely pulverize, soak 2 hours at 50 DEG C with 4 times of 50% ethanol, reflux extraction for 0.5 hours, collect the extract, filter residue with 3 times of 50% ethanol, The mixed solvent consisting of glycerol and dichloromethane was extracted under reflux for 1.5 hours, and the extract was collected; wherein, the volume ratio of 50% ethanol, glycerol and dichloromethane was 5:1:2.

[0077] (2) Combine the extracts, adjust the pH to 7.5 with NaOH solution, let stand for 12h, filter, add water to make it 5 times the volume of Ginkgo biloba;

[0078] (3) add concentrated hydrochloric acid to adjust pH to be 4.5, centrifuge at 4500r / min;

[0079](4) The centrifugate passes through the macroporous adsorption resin column at 1.6BV / h; the resin is washed with 15% ethanol of 1BV of purified water and 2BV at a flow rate of 3.0BV / h, and is a...

Embodiment 3

[0084] Embodiment 3: Ginkgo biloba composition

[0085] 1. Extraction method

[0086] (1) Get ginkgo leaf and dry at 65 DEG C for 5 hours, ultrafinely pulverize, soak 0.5 hour under 60 DEG C with 6 times of 60% ethanol, reflux extraction for 2 hours, collect the extract, filter residue with 5 times of 60% ethanol, The mixed solvent composed of glycerol and dichloromethane was extracted under reflux for 0.5h, and the extract was collected; wherein, the volume ratio of 60% ethanol, glycerol and dichloromethane was 8:1:2.

[0087] (2) Combine the extracts, adjust the pH to 8.0 with NaOH solution, let stand for 24h, filter, add water to make it 6 times the volume of Ginkgo biloba;

[0088] (3) add concentrated hydrochloric acid to adjust the pH to be 5.0, and centrifuge at 5000r / min;

[0089] (4) The centrifuge passes through the macroporous adsorption resin column with 1.8BV / h; washes the resin with the flow rate of 4.0BV / h with the purified water of 1.5BV, 15% ethanol of 1.5BV...

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PUM

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Abstract

The invention relates to a ginkgo leaf composition, and in particular relates to a Shuxuening injection and a preparation method thereof. The Shuxuening injection is made from ginkgo leaf extract which contains 25-40% of total flavonol glycosides, 6.5-16% of ginkgolide, 3-5% of bilobalide and less than 5ppm of ginkgolic acid. The preparation method has the advantages that a harmful ingredient, namely total ginkgolic acid, is effectively removed, and anaphylactoid reactions are reduced. The prepared Shuxuening injection is definite in compositional ratio, good in stability, low in irritability, good in solubility and stable in curative effect.

Description

technical field [0001] The invention relates to a ginkgo leaf composition, in particular to a Shuxuening injection and a preparation method thereof. Background technique [0002] Shuxuening Injection is a sterilized aqueous solution made from Ginkgo biloba extract. Ginkgo biloba is the dried leaf of Ginkgo biloba plant, which is a traditional Chinese medicinal material for promoting blood circulation and removing blood stasis. Ginkgo biloba extract is an enriched product of active substances extracted from Ginkgo biloba through modern extraction technology. It can be used for the treatment of lung deficiency cough and asthma, coronary heart disease, hyperlipidemia, depression, diabetes, neurological disease, memory impairment, peripheral vascular disease, intermittent claudication, brain turning tinnitus and other diseases. Its main active ingredients are flavonoids and terpenes. Flavonoids include monoflavones, flavonol glycosides, acetylated flavonol glycosides, biflavon...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/08A61K36/16A61P11/06A61P9/10A61P3/06A61P25/24A61P3/10A61P25/00A61P25/28A61P9/14A61K127/00
CPCA61K9/0019A61K9/08A61K36/16A61K2236/333A61K2236/35A61K2236/39A61K2236/53A61K2236/55
Inventor 方同华范玉奇周广红贾文娟崔玉海
Owner HEILONGJIANG ZBD PHARMA
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