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Abamectin dispersible tablets and preparation method thereof

A technology of abamectin and dispersible tablets, applied in the field of medicine, can solve the problems of low bioavailability, slow disintegration and the like, and achieve the effects of high release, good application prospect and excellent disintegration performance

Active Publication Date: 2017-02-22
CHENGDU QIANKUN VETERINARY PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, the main dosage forms of avermectin commonly used in veterinary clinics include conventional tablets, capsules, powders, and injections. Some dosage forms have the disadvantages of slow disintegration and low bioavailability.

Method used

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  • Abamectin dispersible tablets and preparation method thereof
  • Abamectin dispersible tablets and preparation method thereof
  • Abamectin dispersible tablets and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] Example 1 Preparation method of abamectin dispersible tablets of the present invention (prescription is based on 1000 tablets)

[0020]

[0021] Preparation:

[0022] (1) Ultrafine pulverization of A at low temperature (-20°C) for 30 minutes to obtain ultrafine powder with a particle size of less than 50μm, and B-G respectively through 80 mesh sieve for use.

[0023] (2) Mix AE for 30 minutes to obtain the mixture, add 20% ethanol to make soft material, pass through a 20-mesh sieve to granulate, and dry at 50°C for more than 12 hours to control the water content of the granules below 3%. Afterwards, add magnesium stearate and micro-powdered silica gel and mix for 30 minutes, press tablets, and get ready.

Embodiment 2

[0024] Example 2 Preparation method of abamectin dispersible tablets of the present invention (prescription is based on 1000 tablets)

[0025] Numbering Raw materials proportion Weight (g) A Avermectin1％25 B starch50％1250 C Microcrystalline cellulose35％875 D Sodium Carboxymethyl Starch8％200 E Low-substituted hydroxypropyl cellulose3％75 F Magnesium stearate2％50 G Micronized silica gel1％25

[0026] Preparation:

[0027] (1) Ultrafine pulverization of A at low temperature (-20°C) for 30 minutes to obtain ultrafine powder with a particle size of less than 50μm, and B-G respectively through 80 mesh sieve for use.

[0028] (2) Mix AE for 30 minutes to obtain the mixture, add 20% ethanol to make soft material, pass through a 20-mesh sieve to granulate, and dry at 50°C for more than 12 hours to control the moisture of the granules below 3%, and then pass through a 20-mesh sieve. Afterwards, add magnesium stearate and micro-powdered silica gel and mix for 30 minutes, press tablets, and get...

Embodiment 3

[0029] Example 3 Preparation method of abamectin dispersible tablets of the present invention (prescription is based on 1000 tablets)

[0030]

[0031] Preparation:

[0032] (1) Ultrafine pulverization of A under low temperature conditions (-20°C) for 30 minutes to obtain ultrafine powder with a particle size of less than 50μm, and B-G respectively through 80 mesh sieve for use.

[0033] (2) Mix AE for 30 minutes to obtain the mixture, add 20% ethanol to make soft material, pass through a 20-mesh sieve to granulate, and dry at 50°C for more than 12 hours to control the moisture content of the granules below 3%. Afterwards, add magnesium stearate and micro-powdered silica gel and mix for 30 minutes, press tablets, and get ready.

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Abstract

The invention discloses abamectin dispersible tablets. The abamectin dispersible tablets are prepared from the following raw and auxiliary materials by weight: 0.5 to 2 parts of abamectin, 40 to 53 parts of starch, 30 to 50 parts of microcrystalline cellulose, 6 to 10 parts of carboxymethyl starch sodium, 2 to 4 parts of low-substituted hydroxypropyl cellulose, 0.5 to 2 parts of magnesium stearate and 0.5 to 2 parts of micro-powder silica gel. The invention further provides a preparation method and application of the abamectin dispersible tablets. The abamectin dispersible tablets prepared by the invention have a rapid disintegration speed, a high releasing rate and a good clinical application prospect.

Description

Technical field [0001] The invention relates to an abamectin dispersible tablet and a preparation method thereof, and belongs to the field of medicine. Background technique [0002] Animal parasitic diseases are diseases caused by various pathogenic parasites that parasitize animals. Since parasites often consume animals chronically in an extremely hidden way, infection and disease are not obvious, and the losses caused are easily overlooked. Parasitic diseases can consume animal nutrition, reduce feed utilization, and cause economic losses. Quite serious, and caused great damage to the rapid development of animal husbandry. The main damage is mainly manifested in causing animal death, reducing animal production performance, affecting animal growth, spreading disease, and causing serious waste of animal products. Currently commonly used antiparasitic drugs include antihelmintics, antiprotozoal drugs and insecticides. Some drugs have certain effects on a variety of parasites in ...

Claims

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Application Information

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IPC IPC(8): A61K31/7048A61K9/20A61K47/36A61K47/38A61K47/12A61K47/04A61P33/00
CPCA61K9/2009A61K9/2013A61K9/2054A61K9/2059A61K31/7048
Inventor 吴学渊房春林杨海涵胡婷婷李超
Owner CHENGDU QIANKUN VETERINARY PHARMA
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