Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Method for quickly detecting water extraction process during preparation of Qizhiweitong granules by use of near-infrared spectroscopy and application

A technology of near-infrared spectroscopy and near-infrared spectroscopy, which is used in measuring devices, weighing by removing certain components, and material analysis by optical means, which can solve the problem of difficult to reflect chemical changes and physical changes in the extraction process. Low efficiency, affecting production efficiency and other problems, to achieve the effect of improving production efficiency and economic benefits, high precision and high accuracy

Inactive Publication Date: 2017-02-08
本溪国家中成药工程技术研究中心有限公司 +1
View PDF8 Cites 2 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, due to the low efficiency of traditional analysis methods, not only greatly affects the production efficiency, but also it is difficult to reflect the complex chemical and physical changes in the extraction process and concentration process

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Method for quickly detecting water extraction process during preparation of Qizhiweitong granules by use of near-infrared spectroscopy and application
  • Method for quickly detecting water extraction process during preparation of Qizhiweitong granules by use of near-infrared spectroscopy and application
  • Method for quickly detecting water extraction process during preparation of Qizhiweitong granules by use of near-infrared spectroscopy and application

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1 Study on the Water Extraction Process of Qizhi Weitong Granules by Near Infrared Spectroscopy

[0066] 1. Instruments and reagents

[0067] 1.1 Main medicinal materials and reagents

[0068] Bupleurum, Radix Paeoniae Alba, Radix Glycyrrhizae, Corydalis Corydalis (burning) (provided by Liaoning China Resources Benxi Sanyao Co., Ltd.); reference substance of paeoniflorin (Chengdu Master Biotechnology Co., Ltd., batch number: MUST-11030608); acetonitrile (Merck, Germany ); Phosphoric Acid (Aladdin); Wahaha Purified Water.

[0069] 1.2 Main instruments and equipment

[0070] Agilent1200 high-performance liquid chromatography (Agilent1200 pump, Agilent1200 photoelectric secondary array detector, Agilent1200 chromatographic workstation, Agilent Technologies, USA); Antaris Fourier transform near-infrared spectrometer (Thermo Nicolet, USA); equipped with a corresponding transmission detector accessory sampling system and signal acquisition and data processing sof...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a method for quickly detecting a water extraction process during the preparation of Qizhiweitong granules by use of near-infrared spectroscopy and application. According to the invention, a near-infrared spectroscopy online analysis method is established for a water extraction process during the preparation of Qizhiweitong granules and applied to online detection, and automatic detection of the water extraction process during the preparation of Qizhiweitong granules and real-time prediction of various quality control index content are realized; the established model has high prediction precision and high accuracy and meets the requirements of quantitative analysis in practical production; and compared with a traditional pharmacopeia method, the method has the advantages that the analysis efficiency is greatly improved on the basis of guaranteeing accuracy, and the quality of the water extraction process can be quickly and efficiently monitored and controlled in real time, so that the safety, stability and effectiveness of the final product quality can be guaranteed.

Description

technical field [0001] The invention belongs to the field of drug detection, and specifically relates to a method and application for rapidly detecting the water extraction process in the preparation process of Qi stagnation Weitong granules by using near-infrared spectroscopy. Background technique [0002] Qi stagnation stomach pain granules are made of 6 traditional Chinese medicines of Bupleurum, Corydalis Corydalis, Fructus Citrifolia, Cyperi Cyperi, Radix Paeoniae Alba and Radix Glycyrrhiza. The treatment of epigastric pain and other diseases has become the first-line drug for clinical treatment of epigastric pain after years of clinical practice. However, the preparation process of Qizhi Weitong Granules is complex and cumbersome, and slight changes in various process parameters in the actual production process may directly affect the quality of the final drug. [0003] Traditional drug analysis techniques generally use off-line analysis methods to collect liquid medi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Applications(China)
IPC IPC(8): G01N21/359G01N30/74G01N5/04
CPCG01N21/359G01N5/04G01N30/74
Inventor 孟宪生谈英张跃飞韩凌邵平林丽峰李题宝何晓霞潘英包永睿王帅李天娇王岩
Owner 本溪国家中成药工程技术研究中心有限公司
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products