Preparation method for extracting pharmaceutical monomer for preventing and treating hyperuricemia and gout from rhizoma smilacis glabrae
A technology for hyperuricemia and Smilax tuckahoe, which is applied in medical formulas, medical preparations containing active ingredients, drug combinations, etc., can solve the problems of low yield of monomer compounds, high cost, time-consuming and heavy taste, and achieve High yield, low cost, and convenient administration
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Embodiment 1
[0024] Embodiment 1, acute toxicity test of the present invention
[0025] Experimental animals: KM mice, SPF grade, male, weighing 18-22 g, provided by the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine. After 3 days of normal feeding, it was tested.
[0026] Drugs and Reagents: Smilax Smilax (Guangzhou Medicinal Herbal Pieces Factory).
[0027] A preparation method for extracting and preventing hyperuricemia and gout medicinal monomer from Smilax smilax according to the present invention, the steps are as follows:
[0028] Add 20 times the amount of 70% ethanol to the raw material Smilax tuckahoe, heat and reflux for 2 hours, add 15 times the amount of 70% ethanol to heat and reflux for 1.5 hours, combine the extracts, refrigerate for 1 day, centrifuge at high speed, discard the insoluble matter, and recover the ethanol under reduced pressure to Relative density 1.2, hydrochloric acid to adjust the pH value to 5, refrigerated for 1 day, ...
Embodiment 2
[0032] Embodiment 2, subchronic toxicity test of the present invention
[0033] Experimental animals: KM mice, SPF grade, male, weighing 18-22 g, provided by the Experimental Animal Center of Guangzhou University of Traditional Chinese Medicine. After 3 days of normal feeding, it was tested.
[0034] Drugs and Reagents: Smilax Smilax (Guangzhou Medicinal Herbal Pieces Factory).
[0035] A preparation method for extracting and preventing hyperuricemia and gout medicinal monomer from Smilax smilax according to the present invention, the steps are as follows:
[0036] Add 20 times the amount of 70% ethanol to the raw material Smilax tuckahoe, heat and reflux for 2 hours, add 15 times the amount of 70% ethanol to heat and reflux for 1.5 hours, combine the extracts, refrigerate for 1 day, centrifuge at high speed, discard the insoluble matter, and recover the ethanol under reduced pressure to Relative density 1.2, hydrochloric acid to adjust the pH value to 5, refrigerated for 1 da...
Embodiment 3
[0041] Embodiment 3, the clinical observation of clinical treatment hyperuricemia and gout of the present invention
[0042] 1. Basic information: All cases come from outpatient clinics, a total of 60 cases, 30 cases for men and 30 cases for men and women. Using the random number table, they were divided into a treatment group of 30 cases and a control group of 30 cases. There was no statistically significant difference in gender, age, and course of disease between the two groups.
[0043] 2. Diagnostic criteria
[0044] 2.1 Western medicine diagnostic criteria
[0045] ①According to the standards set in the "Guidelines for Clinical Diagnosis and Treatment Rheumatism Volume" compiled by the Chinese Medical Association in 2005: male blood uric acid value>417mmol / L; female blood uric acid value>357mmol / L; 1977 American Rheumatism Association standard) (1), specific uric acid crystals were found in synovial fluid; (2), tophi was confirmed to contain sodium urate crystals by che...
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