Traditional Chinese medicine composition for treating Parkinson's disease and preparation method thereof

Abstract

The invention discloses a traditional Chinese medicine composition for treating Parkinson disease. The traditional Chinese medicine composition comprises the following bulk drugs in parts by weight: 1-10 parts of corydalis tuber, 1-10 parts of uncaria, 1-6 parts of fleece-flower root, and 1-6 parts of Ligusticum wallichii. The invention also discloses a preparation method of the traditional Chinese medicine composition. The pharmacological research confirms that the traditional Chinese medicine composition has the effects for mitigating limb tremble, alleviating muscular rigidity, protecting dopaminergic neuron, and delaying the condition development, and can be used for treating Parkinson disease.

Description

technical field [0001] The invention relates to a traditional Chinese medicine composition, in particular to a traditional Chinese medicine composition for treating Parkinson's disease. Background technique [0002] Parkinson's disease (PD) is a progressive neurodegenerative disease that occurs in middle-aged and elderly people, and currently affects about 1% of people over 60 years old. The main pathological mechanism is the degeneration of striatal dopamine (DA) neurons in the substantia nigra pars compacta, resulting in a decrease in DA content in the striatum. Clinically, it is characterized by resting tremor, muscle rigidity, decreased movement, and disturbance of postural adjustment. [0003] In Western medicine, Madopar has long been used as a first-line treatment for PD. It consists of levodopa (L-DOPA) and benserazide. It mainly treats PD by exogenously supplementing the deficiency of DA in the striatum in the brain. The curative effect is exact. Clinical and exp...

AI Technical Summary

Problems solved by technology

Clinical and experimental studies have shown that long-term use of such drugs can reduce the curative effect and cause serious side effects such as "on-off phenomenon" and "end-of-dose phenomenon", and can increase the generation of free radicals in the brain and damage dopamine neurons

The second type of commonly used dopamine receptor agonists, such as bromocriptine, has a protective effect on neurons, has a faster onset of action, and has a longer acting time in the striatum than L-DOPA, and can selectively act on DA receptors, but alone The curative effect is not as obvious as that of L-DOPA when applied, and there are individual differences in the response to the drug, and side effects such as mental symptoms and orthostatic hypotension are prone to occur

[0005] Li Rukui et al. disclosed a traditional Chinese medicine composition consisting of 30g Radix Astragalus Radix, 30g Radix Paeoniae Alba, 15g Uncaria Uncaria, 30g Motherwort, 30g Radix Rhizoma Radix, and 10g Cimicifuga for treating PD. There was no effect on rat rotation behavior, nor could it increase the content of dopamine in the striatum; Pingzhan Decoction 144g / kg continuous intragastric administration for 3 days had a more obvious anti-tremor effect, suggesting that Pingzhan Decoction did not excite the function of dopamine receptors in the brain , nor can it increase the content of neurotransmitters, but it has a certain anti-tremor effect [Li Rukui, Zhao Hong, Tu Yingmei, et al. Effects of Pingzhan Decoction on the behavior of Parkinson's disease model animals and the content of dopamine in the brain [J]. Traditional Chinese Medicine Research, 2000,16(2):40-41]