Probiotic composition with menstruation regulating function and application thereof

A composition and technology of probiotics, applied in the field of primary dysmenorrhea of ​​young women, can solve problems such as side effects of drugs and psychological pressure of patients, and achieve the effects of excellent drug efficacy, promotion of proliferation, and good inhibition

Active Publication Date: 2017-01-11
泰安大凡神农生物有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Long-term medication can cause psychological stress to patients and also cause drug side eff

Method used

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  • Probiotic composition with menstruation regulating function and application thereof
  • Probiotic composition with menstruation regulating function and application thereof
  • Probiotic composition with menstruation regulating function and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0043] Example 1 Probiotic composition with function of regulating menstruation

[0044]A probiotic composition with the function of regulating menstruation, the probiotic composition is composed of Lactobacillus rhamnosus, Lactobacillus plantarum and Bifidobacterium longum.

[0045] Probiotic composition formula 1: Lactobacillus rhamnosus, Lactobacillus plantarum, and Bifidobacterium longum live in a ratio of 1:1:2 for ingredients, wherein the contents of Lactobacillus rhamnosus and Lactobacillus plantarum are 2.5×10 6 CFU / g, the content of Bifidobacterium longum is 5×10 6 CFU / g.

[0046] Probiotic composition formula 2: Lactobacillus rhamnosus, Lactobacillus plantarum, and Bifidobacterium longum live in a ratio of 1:1:2 for ingredients, wherein the content of Lactobacillus rhamnosus and Lactobacillus plantarum is 2.5×10 7 CFU / g, the content of Bifidobacterium longum is 5×10 7 CFU / g.

[0047] Probiotic composition formula 3: Lactobacillus rhamnosus, Lactobacillus planta...

Embodiment 2

[0049] Example 2 Products with the function of regulating menstruation

[0050] Prepare as follows:

[0051] (1) Preparation of active probiotic dry powder:

[0052] 1) Inoculate Lactobacillus rhamnosus, Lactobacillus plantarum and Bifidobacterium longum in the fermentation medium after being activated by the culture medium, and culture with shaking, so that the concentration of the bacteria reaches the logarithmic growth phase of 0.5-2×10 9 CFU / mL.

[0053] Preparation of Bifidobacterium seed solution: Take out the strain preservation tube, scratch the plate with Bifidobacterium solid medium for recovery, and culture anaerobically at 37°C for 48-72 hours. Pick a single colony under the plate to inoculate 50 ml of bifidobacterium medium, and cultivate it in an anaerobic incubator for 48 hours. Seeds are inoculated into a 3L large triangular flask (filling volume is 2.5L) with 5% inoculum amount, oil-sealed with sterile vegetable oil, cultured anaerobically at 37 degrees for...

Embodiment 3

[0063] Example 3 Product Test Verification with Menstruation Regulating Function

[0064] 1. Animal experiments

[0065] Construction, grouping and administration of mouse primary dysmenorrhea model: select 80 female Kunming white mice of 18-22 g, and randomly divide them into 8 treatment groups, which are blank control group, model group and positive group (commercially available). Product Yueyue Shutongjingbao Granules), product 1, product 2, product 3, product 4 groups, 10 in each group. Except for the blank group, the other groups were combined with estrogen and oxytocin to reproduce the primary dysmenorrhea model, and the specific operation was as follows: 10 mg·kg -1 d -1 Give mice continuous intraperitoneal injection of estradiol benzoate for 10 days to synchronize the uterus of mice. From the 4th day, the normal group and the model group were given an equal amount of distilled water, and the other groups were given human equivalents of medicine (the dosage for human ...

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Abstract

The invention belongs to the field of biomedicines and in particular relates to a probiotic composition with a menstruation regulating function and application thereof. The probiotic composition is suitable for menstrual-period dysmenorrhea of females and is particularly suitable for primary dysmenorrhea of young females. The probiotic composition with the menstruation regulating function is prepared from lactobacillus rhamnosus, lactobacillus plantarum and bifidobacterium longum. The probiotic composition can also be compounded with traditional Chinese medicines which have the menstruation regulating function and can be used as medicines and foods, and has a synergistic effect. Probiotics are internationally recognized probiotic substances and have the advantages of safe source, remarkable effect, no toxic or side effect and the like. The probiotic composition provided by the invention can be safely eaten and also has the menstruation regulating function; the probiotic composition can be particularly used for inhibiting the primary dysmenorrhea and a novel application of the probiotics is provided. The probiotics are compounded with the traditional Chinese medicines capable of being both used as medicines and foods, and advantages are commonly expressed, so that the effect of safely and effectively treating the dysmenorrhea is realized.

Description

technical field [0001] The invention belongs to the field of biomedicine, and in particular relates to a probiotic composition with a function of regulating menstruation and an application thereof, which is suitable for women with menstrual dysmenorrhea, especially for young women with primary dysmenorrhea. Background technique [0002] Dysmenorrhea is a common clinical gynecological disease. It refers to the disease of lower abdomen or waist pain, even pain reaching the lumbosacral area, during menstrual period and before and after. Cold, even fainting. According to relevant surveys, the incidence of dysmenorrhea is 33.19%, 45.73% for mild, 38.81% for moderate, and 13.55% for severe. The primary dysmenorrhea of ​​young women reaches 75%, which has a serious impact on women's life, social life, and health. Long-term dysmenorrhea can also cause infertility, induce various gynecological diseases, and at the same time affect the baby's development in the womb make an impact. ...

Claims

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Application Information

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IPC IPC(8): A61K35/747A61K36/9068A61P15/00A61K35/745
CPCA61K35/745A61K35/747A61K36/484A61K36/725A61K36/752A61K36/77A61K36/815A61K36/9068A61K2300/00
Inventor 单宝龙张建梅樊梅娜陈甜甜房栋程秀芳蒋延超杨婷婷
Owner 泰安大凡神农生物有限公司
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