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A kind of content determination method of traditional Chinese medicine composition

A measurement method and composition technology, applied in the direction of measuring devices, instruments, scientific instruments, etc., can solve the problems of slow analysis speed, consumption of organic reagents, long time consumption, etc.

Active Publication Date: 2020-07-21
SHIJIAZHUANG YILING PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The traditional analysis method is slow in analysis speed, takes a long time, and consumes a large amount of organic reagents, which increases environmental pollution

Method used

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  • A kind of content determination method of traditional Chinese medicine composition
  • A kind of content determination method of traditional Chinese medicine composition
  • A kind of content determination method of traditional Chinese medicine composition

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0075] Embodiment 1: the preparation of medicine capsule of the present invention

[0076] prescription:

[0077] Astragalus 70g Talc 14g Prunella vulgaris 21g Ligustrum lucidum 14g

[0078] 21 grams of lychee core, 2.1 grams of amber, 2.8 grams of cinnamon, and 7 grams of cork

[0079] Preparation:

[0080] (1) Weigh the Chinese herbal medicines according to the prescription amount, select them separately, and crush them;

[0081] (2) Take Astragalus membranaceus and Cortex Phellodendri, add 60% ethanol, heat and reflux to extract twice, add 10 times the amount for the first time, extract for 2 hours, add 8 times the amount for the second time, extract for 1 hour, filter the extract, combine, After the ethanol is recovered under reduced pressure, it is concentrated into a clear paste with a relative density of 1.20-1.25, put into a vacuum drying oven, and dried under reduced pressure at a temperature of 65°C and a vacuum degree of 0.05Mpa, and the dry paste is used for lat...

Embodiment 2

[0109] Embodiment 2: the preparation of pharmaceutical tablet of the present invention

[0110] prescription:

[0111] Astragalus 30 grams, talc 7 grams, Prunella vulgaris 10 grams, Ligustrum lucidum 7 grams

[0112] 10 grams of lychee core, 1 gram of amber, 1.5 grams of cinnamon, 3 grams of cork

[0113] Preparation:

[0114] (1) Weigh the Chinese herbal medicines according to the prescription amount, select them separately, and crush them;

[0115] (2) Take Radix Astragali and Cortex Phellodendri, add 60% ethanol, heat and reflux to extract twice, add 9 times the amount for the first time, extract for 3 hours, add 8 times the amount for the second time, extract for 1.5 hours, filter the extract, combine, After the ethanol is recovered under reduced pressure, it is concentrated into a clear paste with a relative density of 1.20-1.25 for subsequent use;

[0116] (3) Take Ligustrum lucidum, add 7 times the amount of 80% ethanol, heat and reflux to extract twice, the time is...

Embodiment 3

[0136] Embodiment 3: the preparation of medicine capsule of the present invention

[0137] prescription:

[0138] 150 parts of astragalus, 28 parts of talc, 40 parts of Prunella vulgaris, 28 parts of Ligustrum lucidum

[0139] 40 parts of lychee core, 4 parts of amber, 6 parts of cinnamon, and 15 parts of cork.

[0140] Preparation method: make capsules according to conventional preparation methods.

[0141] The assay method consists of the following steps:

[0142] A, the preparation of need testing solution: take by weighing the content of traditional Chinese medicine composition of the present invention, get about 3g, accurately weigh, put in the conical flask with stopper, add 50% methyl alcohol 75ml accurately, weigh, ultrasonic treatment 60 minutes , let it cool, weigh it, make up the lost weight with 50% methanol, shake well, and you get it.

[0143] B. Preparation of reference substance solution: Weigh an appropriate amount of calycosin glucoside, privetin, palmati...

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Abstract

The traditional Chinese medicine composition of the present invention adopts the UPLC method to simultaneously measure the contents of the active ingredients calycosin glucoside, privetin, palmatine hydrochloride, berberine hydrochloride and rosmarinic acid. The method is simple and fast, and is applicable to this invention. The quality control of the inventive traditional Chinese medicine composition provides a reference for the dynamic and constant monitoring in the continuous production of the inventive traditional Chinese medicine composition.

Description

technical field [0001] The invention relates to a method for determining the content of a traditional Chinese medicine composition, which belongs to the field of analysis of traditional Chinese medicines, and in particular to a method for determining the content of each component in a traditional Chinese medicine composition. Background technique [0002] The traditional Chinese medicine composition of the present invention is mainly composed of traditional Chinese medicines such as Astragalus, Cortex Phellodendri, Cinnamon, Prunella vulgaris, Ligustrum lucidum and other traditional Chinese medicines. The principle of treatment is to invigorate the spleen and kidney, diuresis and dissipate stagnation, and provide patients with a clinical treatment for the main symptoms of benign prostatic hyperplasia. A new Chinese medicine preparation with definite curative effect and safe taking [Su Pingju, Liu Ying, Li Song, Gao Peng, Zhao Shaohua, Liu Minyan. Determination of three active...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N30/02G01N30/06
Inventor 王玉峰欧阳玥李松李向军王岳刘敏彦
Owner SHIJIAZHUANG YILING PHARMA
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