AIDS Infected Cell Separator

Abstract

The invention relates to an AIDS-infected cell separator in the field of biomedicine, which is characterized in that it is made of a high-biocompatibility material that can pass through a single blood cell and chemical components but cannot pass through two or more large-volume cells that are bonded together. 150~250μm, 50~150μm, 15~40μm, 8~15μm, 5~8μm, 3~5μm, 1~2μm, correspondingly calibrated as type I~VII cell separators, simultaneously prepare HIVgp120 and CD4 antibodies, HIV infection The gp120 on the cell surface can bind other CD4+ cells by itself or under the action of gp120 antibody or CD4 antibody to form large multinucleated giant cells. Type I-II separators are used to separate super-large fungi, spirochetes, and tumor cells. HIV-infected large-volume multinucleated giant cells, multicellular aggregates, CD4+ cells susceptible to HIV infection, and AIDS-infected cells are separated and cleared in the extracorporeal circulation composed of separators and other components.

Description

technical field [0001] The invention relates to an AIDS-infected cell separator, which is mainly used in the field of biomedicine to filter and remove CD4+ cells infected by HIV in the blood of AIDS patients, so as to achieve the purpose of treating AIDS. Background technique [0002] AIDS is an infectious disease caused by human immunodeficiency virus (Human Immunodeficiency Virus, HIV). So far, 208 countries and regions in the world have been seriously threatened by AIDS. About 40 million people have been infected with AIDS, and the death toll has exceeded 20 million. About 6,000 people become AIDS-infected people every day, and more than 300 people die every day. on AIDS. HIV-infected people in China are in a period of rapid growth, and the number has far exceeded 1 million at present. AIDS has become another major infectious disease facing mankind after tumors, cardiovascular and cerebrovascular diseases, tuberculosis, and diabetes, and has become a serious public heal...

AI Technical Summary

Problems solved by technology

[0005] Judging from the current AIDS treatment methods that have been used clinically, the effect is not so ideal: (1) HIV reverse transcriptase inhibitors: can only prevent the infection of susceptible cells that have not been infected with HIV, and have no therapeutic effect on infected cells, and are toxic There are many side effects, including mitochondrial toxicity, myelosuppression, erythrocytic anemia, neutropenia and thrombocytopenia, pancreatitis, and the generation of cross-drug resistance. Drug-resistant variants, resulting in decreased clinical efficacy or failure

(2) HIV protease inhibitors: prone to drug-induced liver injury, lipid metabolism disorders and other side effects and drug resistance

(4) Inhibiting HIV virus entry inhibitors: including blocking the binding of gp120 to CD4, blocking the binding of HIV to coreceptors, acting on gp41 membrane subunits, and acting on CC chemokine receptor 5 (CCR5) on the surface of T lymphocytes to block HIV from entering host cells, but has side effects on the liver and heart

(6) HIV vaccine treatment: Due to the particularity of HIV, such as innate immunity is not enough to resist HIV and its targeted destruction of the immune system, and the virus mutates rapidly, so far no truly safe and effective vaccine has been developed

(7) Gene therapy: HIV gene therapy research has never stopped, including antisense technology, RNA decoy, RNA interference, intracellular antibodies, dominant negative mutants, suicide genes, etc., but gene therapy that has entered phase II clinical trials hardly

[0007] In short, various drugs and biological products cannot kill HIV in the body, and they are expensive and have severe side effects. So far, there is no effective method for the treatment of AIDS, which has become a worldwide problem that cannot be overcome for a long time.

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