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aids treatment responder

A reactor, CD4 technology, applied in the field of biomedicine, to achieve the effect of high cost and large side effects

Active Publication Date: 2018-12-04
ATTACHED OBSTETRICS & GYNECOLOGY OSPITAL MEDICALCOLLEGE ZHEJIANG UNIV +1
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  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there is no report on the preparation of CD4+ T cells for the treatment of AIDS in vitro

Method used

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Experimental program
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Embodiment Construction

[0010] figure 1 It is an application schematic diagram of the AIDS treatment reactor proposed according to the present invention.

[0011] figure 2 It is a schematic diagram of the internal structure of the plasma separator proposed according to the present invention.

[0012] image 3 It is a schematic diagram of the internal structure of the AIDS treatment reactor proposed according to the present invention.

[0013] figure 1 Among them, one end of the arterial blood line tube (1) is connected with the arterial blood vessel, and the other end is connected with the plasma separator (4) through the heparin pump (2) and the blood pump (3), and the plasma separator (4) is connected through the plasma pump (6) ) and circulation pipeline (7) are connected with two parallel reactors (8), reactor (9), and then connected with circulation pipeline (10), vein pipeline (5) successively, vein pipeline (5) The other end is connected to the vein.

[0014] figure 2 Among them, 1 is...

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Abstract

The invention relates to an AIDS treatment reactor in the field of biomedicine, which is characterized in that an immortal cell line is prepared by integrating an exogenous gene to change the gene structure of a T cell, and the T cell surface antibody is used as a cell growth activator to artificially prepare a cell that can bind HIV and produce The CD4+ cells of cytokines are wrapped with highly biocompatible materials, which can not only prevent cells and their fragments, and even HIV from filtering out, but also provide a place for CD4+ cells to produce cytokines and bind HIV. When the plasma separated in vitro When HIV flows through the reactor, it combines with CD4+ cells or enters the cells to be eliminated, and the cytokines produced at the same time flow out through the intercellular space with the plasma and are reinfused into the body, thereby realizing the elimination of HIV and the supplementation of cytokines to lead HIV out of the body The artificial CD4+ T cell replacement therapy that has been removed is more feasible and has no toxic side effects than the traditional therapy that is limited to killing HIV in the body but is difficult to achieve.

Description

technical field [0001] The invention relates to an AIDS treatment reactor in the field of biomedicine, which is mainly used for removing HIV dissociated outside the blood cells of AIDS patients in vitro, and at the same time replenishing CD4+T cell factors lacking in the body of AIDS patients to achieve the purpose of treating AIDS. Background technique [0002] AIDS is an infectious disease caused by human immunodeficiency virus (Human Immunodeficiency Virus, HIV). So far, 208 countries and regions in the world have been seriously threatened by AIDS. About 40 million people have been infected with AIDS, and the death toll has exceeded 20 million. About 6,000 people become AIDS-infected people every day, and more than 300 people die every day. on AIDS. HIV-infected people in China are in a period of rapid growth, and the number has far exceeded 1 million at present. AIDS has become another major infectious disease facing mankind after tumors, cardiovascular and cerebrovasc...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61M1/36
CPCA61M1/3692A61M1/3616
Inventor 翁炳焕李兰娟虞晓鹏杨艳梅黄颖之
Owner ATTACHED OBSTETRICS & GYNECOLOGY OSPITAL MEDICALCOLLEGE ZHEJIANG UNIV
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