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Dapsone-containing gel preparation and preparation method thereof

A dapsone and gel technology, which is applied in the field of preparation of dapsone gel preparations, can solve the problems of low absorption in vitro, reduce patient compliance, affect the curative effect of dapsone gel, and the like, achieve good curative effect, increase Skin permeability, the effect of killing deep fungus

Inactive Publication Date: 2017-01-04
BEIJING VENTUREPHARM BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, the formula and process of the above-mentioned patents did not solve the problem of low in vitro absorption, which affected the curative effect of dapsone gel and reduced patient compliance.

Method used

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  • Dapsone-containing gel preparation and preparation method thereof
  • Dapsone-containing gel preparation and preparation method thereof
  • Dapsone-containing gel preparation and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0022] This embodiment is in the form of a gel. (Based on 1000g)

[0023]

[0024] Preparation Process:

[0025] a) Preparation of liquid medicine: Add Tween 80 (60g) and the pulverized active ingredient dapsone (50g) in the prescription into water (200g), heat in a water bath at 45°C to dissolve;

[0026] b) Preparation of matrix: weigh ethyl p-hydroxybenzoate (3g) and add it to ethanol (20g), heat it in a water bath at 45°C to dissolve it, then add glycerin (30g), propylene glycol (10g) and the rest of the water (565g), then slowly add hydroxypropylmethylcellulose (62g) to the above solution under stirring, stir well, make swelling and disperse evenly, and prepare a gel matrix;

[0027] c) Add the liquid medicine dropwise into the gel matrix, stir evenly, and divide into packages.

[0028] In order to highlight the advantages and feasibility of this process, we will use several comparative examples and examples for parallel comparison.

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Abstract

The invention provides a dapsone-containing gel preparation and a preparation method thereof and belongs to the new technical field of medicines. The effective ingredient of the gel preparation is dapsone which is a sulfone type bacteriostatic agent, and the gel preparation has a sterilization effect when used in a large-dosage manner, has been used for treating leprosy clinically previously and is found that the gel preparation can also be used for treating nodular acne. A penetration enhancer is preferably selected for the gel preparation, so that the gel preparation has a good penetration property and a high deep sterilization function, can clear deep acne, is convenient to use, attractive in appearance and easy to clean and has no irritation to skin.

Description

technical field [0001] The invention belongs to the technical field of pharmaceutical gel preparations, and in particular relates to a preparation method of a dapsone gel preparation with more stable quality and capable of removing deep infection. Background technique [0002] Dapsone, its chemical name is: 4,4'-sulfonyl dianiline, the English name is Dapsone, and its molecular formula is C 11 h 12 N 2 o 2 S, the molecular weight is 248.31. Its chemical structure is as follows: [0003] [0004] Dapsone Gel was developed by Allergan, of which the 5% specification was approved by the US FDA in 2006, and the 7.5% specification was approved by the US FDA in 2016 for the treatment of acne vulgaris. It can effectively clear up acne, and Side effects such as skin redness and dryness are mild. [0005] ACZONE ® (ACZONE ® It is the product name of this product. It is not yet on the market in China, so there is no Chinese name. The following are ACZONE ® Indicates the tra...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/06A61K31/145A61K47/22A61K47/10A61K47/32A61K47/38A61K47/36A61P17/10
CPCA61K9/0014A61K9/06A61K31/145A61K47/10A61K47/22A61K47/32A61K47/36A61K47/38
Inventor 周梦婷马莉
Owner BEIJING VENTUREPHARM BIOTECH
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