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Soluble micromolecular beta-1,3-glucan for improving immunity of hepatitis patient

A technology of dextran and small molecules, which is applied in the field of medicine, can solve the problems of poor solubility, low physiological activity, and lower molecular weight, and achieve the effects of clear ingredients, improved physiological activity, and reduced impurity components

Active Publication Date: 2016-12-21
SHANDONG UNIV QILU HOSPITAL
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] Aiming at the disadvantages of macromolecular β-1,3-glucan curdlan gum having poor solubility and low physiological activity, the present invention has developed a high-purity macromolecular β-1,3-glucan curdlan gum as raw material through A series of physical means reduce its molecular weight to produce soluble high-purity small molecule β-1,3-glucan

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] The specific preparation process steps of a soluble small molecule β-1,3-glucan used to improve the immunity of hepatitis patients are as follows:

[0034] (1) Raw materials: select high-purity curdlan gum (more than 90%), and the particle size of the curdlan gum product is more than 200 mesh and less than 74 μm;

[0035] (2) Superfine pulverization, the pulverization technology is airflow superfine pulverization, and the pulverization particle size is below 4 μm;

[0036] (3) High-pressure homogenization, suspending the pulverized and qualified powder in step (2) in deionized water, using a high-pressure homogenizer for circulation homogenization, and controlling the liquid temperature below 45°C, the pressure is 60MPa, and the concentration of the polysaccharide suspension 0.5%, the crushed particle size is below 50nm;

[0037] (4) Centrifugal separation, after diluting the circulating homogeneous liquid obtained in step (3) 3 times with deionized water and mixing, a...

Embodiment 2

[0044] The specific preparation process steps of a soluble small molecule β-1,3-glucan used to improve the immunity of hepatitis patients are as follows:

[0045] (1) Raw materials: select high-purity curdlan gum (more than 90%), and the particle size of the curdlan gum product is more than 200 mesh and less than 74 μm;

[0046] (2) Superfine pulverization, the pulverization technology is airflow superfine pulverization, and the pulverization particle size is below 4 μm;

[0047] (3) High-pressure homogenization, suspend the crushed and qualified powder in step (2) in deionized water, use a high-pressure homogenizer to perform circulation homogenization, and control the liquid temperature below 40°C, the pressure is 45MPa, the concentration of the polysaccharide suspension 0.75%, the crushed particle size is below 50nm;

[0048] (4) Centrifugal separation, after diluting the circulating homogeneous solution obtained in step (3) 6 times with deionized water and mixing, adopt a...

Embodiment 3

[0056] Take the β-1,3-glucan prepared in Example 1, the excipients are medicinal starch, dextrin and ethanol with a mass fraction of 50%, and the above raw materials are fully stirred and mixed to form granules. After drying for 2-4 hours, it is made into flakes, which are convenient for patients to take.

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Abstract

The invention discloses soluble micromolecular beta-1,3-glucan for improving the immunity of a hepatitis patient. The purity of the obtained target product the soluble micromolecular beta-1,3-glucan is above 95% through treatment of a series of physical methods. The target product the soluble micromolecular beta-1,3-glucan is completely water soluble, the physiological activity, especially the biology immune activity, anti-inflammatory activity and the antitumor activity have a very significant effect, and especially the soluble micromolecular beta-1,3-glucan is used for auxiliary treatment of the hepatitis patient and can improve the immunity of the hepatitis patient.

Description

technical field [0001] The invention relates to a soluble small molecule beta-1,3-glucan for improving the immunity of hepatitis patients, a preparation method and application thereof, and belongs to the technical field of medicine. Background technique [0002] Hepatitis is a general term for liver inflammation. It usually refers to the damage of liver cells and the damage of liver function caused by various pathogenic factors such as viruses, bacteria, parasites, chemical poisons, drugs, alcohol, autoimmunity and other factors. Abnormalities in functional indicators and cause a series of symptoms of discomfort in the body. Improving autoimmunity can slow down the progression of hepatitis, thereby effectively reducing the progression of the disease to cirrhosis or even liver cancer. [0003] At present, the drugs that can improve the immunity of patients with hepatitis mainly include thymosin and thymopentin. The active ingredient of thymosin is not clear, the content is ...

Claims

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Application Information

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IPC IPC(8): C08B37/02A61K31/716A61P1/16A61P35/00A61P29/00A61P37/02A23L33/125
CPCA23V2002/00A61K31/716C08B37/0003C08B37/0024A23V2200/30A23V2200/324A23V2200/308A23V2250/5042
Inventor 陈龙岩
Owner SHANDONG UNIV QILU HOSPITAL
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