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Thirst quenching and blood glucose reducing capsules and preparation method thereof

A capsule and hypoglycemic technology, which is applied in the direction of capsule delivery, pharmaceutical formula, medical preparations containing active ingredients, etc., can solve the problems of backward technology, impact on application, low content of quercetin, etc., to achieve improved curative effect, significant effect, Preparation technology and quality control stable effect

Active Publication Date: 2016-12-21
华夏国药(菏泽)制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0002] Xiaoke Jiangtang Capsules are recorded in the standards of the State Food and Drug Administration. The prescription is 3000g of guava leaves, an appropriate amount of starch, and magnesium stearate to make 1000 capsules, and each capsule contains 0.3g (equivalent to 3g of the original medicinal material). Among them, Xiaoke Jiangtang Capsules has a single component, and the curative effect is not obvious. There is no report on the use of supercritical technology in the extraction of Xiaoke Jiangtang Capsules from guava leaves. The original method uses traditional water extraction and alcohol precipitation, which is rough and technically It is backward, the content of quercetin, the main medicinal ingredient contained in the extract, is low, and there are many impurities in the extraction. The follow-up preparation process and quality control are unstable, which seriously affects the clinical application of this product.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0014] A Xiaoke Jiangtang capsule, characterized in that the Xiaoke Jiangtang capsule is prepared from the following raw materials: Astragalus 30g, Rehmannia 20g, Atractylodes 20g, Yuanshen 27g, Pueraria 20g, Salvia 30g, Ophiopogon japonicus 5g, Mulberry 5g leaves, 5g sunburn grass, 30kg guava leaves, 75% ethanol solution, 13g starch, 2g magnesium stearate;

[0015] The preparation method of the Xiaoke Jiangtang capsule is:

[0016] (1) Pulverize 30kg of guava leaves, pass through a 60-mesh sieve, and add to CO 2 In the supercritical extractor, 75% ethanol is used as the entrainer, the entrainer accounts for 6% by volume of the total extraction solvent, the extraction pressure is 20Mpa, the temperature is 50°C, and the CO 2 The flow rate is 3ml per minute per gram of medicinal material, and the extraction time is 4 hours to obtain a supercritical extract;

[0017] (2) 30g astragalus, 20g raw land, 20g herb, 27g root ginseng, 20g kudzu root, 30g salvia miltiorrhiza, 5g Ophiop...

Embodiment 2

[0029] A Xiaoke Jiangtang capsule, characterized in that the Xiaoke Jiangtang capsule is prepared from the following raw materials: Astragalus 25g, Rehmannia 15g, Atractylodes 15g, Yuanshen 25g, Pueraria radix 15g, Salvia miltiorrhiza 25g, Ophiopogon japonicus 3g, Mulberry 3g leaves, 3g sunburn grass, 30kg guava leaves, 75% ethanol solution, 10g starch, 2g magnesium stearate;

[0030] The preparation method of the Xiaoke Jiangtang capsule is:

[0031] (1) Pulverize 30kg of guava leaves, pass through a 60-mesh sieve, and add to CO 2 In the supercritical extractor, 75% ethanol is used as the entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 20Mpa, the temperature is 48°C, and the CO 2 The flow rate is 3ml per minute per gram of medicinal material, and the extraction time is 4 hours to obtain a supercritical extract;

[0032] (2) Grind 25g of astragalus, 15g of raw land, 15g of atractylodes rhizome, 25g of ro...

Embodiment 3

[0038] A Xiaoke Jiangtang capsule, characterized in that the Xiaoke Jiangtang capsule is prepared from the following raw materials: Astragalus 35g, Rehmannia 25g, Atractylodes 25g, Yuanshen 35g, Pueraria 25g, Salvia miltiorrhiza 35g, Ophiopogon japonicus 6g, Mulberry 6g leaves, 6g sunburn grass, 30kg guava leaves, 75% ethanol solution, 15g starch, 3g magnesium stearate;

[0039] The preparation method of the Xiaoke Jiangtang capsule is:

[0040] (1) Pulverize 30kg of guava leaves, pass through a 60-mesh sieve, and add to CO 2 In the supercritical extractor, 75% ethanol is used as the entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 20Mpa, the temperature is 52°C, and the CO 2 The flow rate is 3ml per minute per gram of medicinal material, and the extraction time is 4 hours to obtain a supercritical extract;

[0041] (2) Grind 35g of astragalus, 25g of raw land, 25g of atractylodes rhizome, 35g of root gin...

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PUM

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Abstract

The invention discloses thirst quenching and blood glucose reducing capsules and a preparation method thereof. The thirst quenching and blood glucose reducing capsules are prepared from the following raw materials: 25-35g of radix astragali, 15-25g of radix rehmanniae, 15-25g of rhizoma atractylodis, 25-35g of radix scrophulariae, 15-25g of radix puerariae, 25-35g of salvia miltiorrhiza, 3-6g of radix ophiopogonis, 3-6g of folium mori, 3-6g of radix glycyrrhizae preparata, 30kg of guava leaf, 75% ethanol solution, 10-15g of starch and 1-3g of magnesium stearate. In the capsules prepared by the method, the content of the main component quercetin is greatly increased, and thus the product is clinically applied relatively well.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a Xiaoke Jiangtang capsule and a preparation method thereof. Background technique [0002] Xiaoke Jiangtang capsules are recorded in the standards of the State Food and Drug Administration. The prescription is 3000g of guava leaves, appropriate amount of starch, and magnesium stearate to make 1000 capsules. Each capsule contains 0.3g (equivalent to 3g of the original medicinal material). Among them, Xiaoke Jiangtang Capsules has a single component, and the curative effect is not obvious. There is no report on the use of supercritical technology in the extraction of guava leaves in Xiaoke Jiangtang Capsules. The original method uses traditional water extraction and alcohol precipitation, which is rough and technically difficult. It is backward, the content of quercetin, the main medicinal ingredient contained in the extract, is low, and there are ...

Claims

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Application Information

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IPC IPC(8): A61K36/8968A61K9/48A61P3/10
CPCA61K9/4866A61K36/284A61K36/481A61K36/484A61K36/488A61K36/537A61K36/605A61K36/61A61K36/804A61K36/808A61K36/8968A61K2236/331A61K2236/37A61K2236/39A61K2236/51A61K2300/00
Inventor 陈长印马朝霞王星星
Owner 华夏国药(菏泽)制药有限公司
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