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Application of atractylone in preparation of medicine for treating acute lung injury

A technology for acute lung injury and atractylodes ketone, which is applied in the field of new medical uses of atractylodes ketone, can solve the problems of no special benefit in early treatment, cannot prevent acute lung injury, etc., achieves good application prospects and application value, and relieves pulmonary inflammation. , the effect of reducing death

Inactive Publication Date: 2018-09-04
上海市浦东新区传染病医院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0009] At present, there are no specific drugs and methods for the treatment of acute lung injury. Glucocorticoids are commonly used in clinical practice to control inflammation, but a large number of studies have shown that they can neither prevent the occurrence of acute lung injury nor have special benefits for early treatment.

Method used

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  • Application of atractylone in preparation of medicine for treating acute lung injury
  • Application of atractylone in preparation of medicine for treating acute lung injury
  • Application of atractylone in preparation of medicine for treating acute lung injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0037] Embodiment 1, supercritical carbon dioxide extraction and silica gel column chromatography separate atractylone

[0038] Supercritical carbon dioxide extraction was carried out using a HA121 supercritical liquid extraction apparatus (Huaan Instrument Factory, Jiangsu, China). Take 100 g of herb decoction pieces and crush them into powder, place them in an extraction kettle, and extract them dynamically at a pressure of 350 bar and a temperature of 50 °C for 60 min, with ethanol (99.9%) as a modifier, and a flow rate of 5 ml / min. The flow rate of supercritical carbon dioxide was set to 15g / min, and the static extraction time was set to 30min. Removal of solvent gave 5.8% product. Supercritical carbon dioxide extracts for in vitro studies were dissolved in phosphate buffer at a concentration of 1 mg / ml.

[0039] The supercritical CO2 extract (50 g) was applied to a silica gel column and separated using petroleum ether (boiling point 60~90°C) and ethyl acetate (30:1→1:1,...

Embodiment 2

[0040] The preparation of embodiment 2, atractylodes ketone tablet

[0041] Element

[0042] Add dextrin, microcrystalline cellulose, starch, lactose to Atractylodes ketone (prepared according to the method of Example 1) according to the prescription amount and mix evenly to make granules, add magnesium stearate, mix evenly, and tablet, to obtain (per Tablets containing atractylone 0.05g). The recommended oral dosage for adults is 1-4 tablets / time, 2-3 times a day.

Embodiment 3

[0043] Embodiment 3, the preparation of atractylodes capsule

[0044] Element

Dosage per capsule

atractylone

50mg

dextrin

37.45mg

microcrystalline cellulose

10.5mg

starch

17.5mg

lactose

10.5mg

[0045] Atractylone (prepared by the method of Example 1) dextrin, microcrystalline cellulose, starch and lactose are mixed according to the prescription amount, after being made into granules, filled into No. 0 hard capsule shells, and polished to obtain (per Capsules contain atractylone 0.05g). The recommended oral dosage for adults is 1-4 capsules / time, 2-3 times a day.

[0046] The present invention will be further illustrated by the pharmacology and activity experiments and results of atractylone in the following test examples.

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Abstract

The invention discloses an application of atractylon, which is shown as a structural formula (I), in preparing medicines for treating acute lung injury. On the basis of results of pharmacological and active experiments, the atractylon is capable of significantly relieving lung inflammation in mice with the acute lung injury, so that the death rate of animals is reduced; and the action of the atractylon is closely related to activating the generation of TLR7-induced type I interferon and inhibiting the activation of NF-kB. The results indicate that the atractylon, which can be used for preparing the effective drugs for treating the acute lung injury, has good application prospect and application value (as shown in Description).

Description

technical field [0001] The present invention relates to the field of Chinese medicine chemistry and medical technology, in particular to Atractylodis Rhizoma ) The new medicine application of the atractylon (Atractylon) extracted in the preparation. Background technique [0002] Acute lung injury (acute lung injury) is very common in clinical practice. It is a clinical syndrome caused by characteristic pathological changes in lung tissue structure caused by various reasons. Extensive pulmonary edema, atelectasis, increased intrapulmonary shunt, decreased compliance, clinical manifestations can be acute progressive, paroxysmal dyspnea. The pathogenesis of acute lung injury is still unclear, but it is currently believed to be caused by the following two factors: 1. Direct damage to lung cells by pathogenic factors, such as lung infection, lung contusion, drowning, inhalation of toxic substances, etc.; 2. , Indirect results of acute systemic inflammatory responses of various ...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/343A61P11/00
CPCA61K31/343
Inventor 成扬陈建杰张银华胡晓凤朱敏芳
Owner 上海市浦东新区传染病医院
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