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Mezlocillin sodium freeze-dried powder injection and preparation method thereof

A technology of mezlocillin sodium and freeze-dried powder injection, which is applied in the field of medicine, can solve the problems of poor stability of mezlocillin sodium, and achieve the effects of improved stability, high stability and simple process of the preparation

Inactive Publication Date: 2016-12-07
NANJING ZHENGKUAN MEDICAL TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The existing technology solves the problem of poor stability of mezlocillin sodium by adding various freeze-dried proppants, metal ion chelating agents and antioxidants and other additives

Method used

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  • Mezlocillin sodium freeze-dried powder injection and preparation method thereof
  • Mezlocillin sodium freeze-dried powder injection and preparation method thereof
  • Mezlocillin sodium freeze-dried powder injection and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] Embodiment 1 mezlocillin sodium freeze-dried powder injection prescription and its preparation process

[0017]

[0018] Preparation Process:

[0019] Bottle washing, sterilizing and drying: the vials are first cleaned by an ultrasonic bottle washing machine, then sterilized and dried by a sterilizing dryer, and sent to the filling room for later use.

[0020] Butyl rubber stopper treatment: After the butyl rubber stopper is cleaned by a rubber stopper cleaning machine, it is sterilized by steam at 121°C for 20 minutes, and dried for later use.

[0021] Aluminum-plastic cover treatment: wash the aluminum-plastic cover with an aluminum cover washing machine, sterilize, dry, and take it out for use.

[0022] Preparation of the medicinal solution: Weigh the prescribed amount of mezlocillin sodium, isonicotinamide, and propyl gallate, add them to water for injection cooled to 10-15°C, stir and dissolve, circulate and filter, measure the pH of the medicinal solution to 5...

Embodiment 2

[0025] Embodiment 2 mezlocillin sodium freeze-dried powder injection prescription and its preparation process

[0026]

[0027] Preparation Process:

[0028] Bottle washing, sterilizing and drying: the vials are first cleaned by an ultrasonic bottle washing machine, then sterilized and dried by a sterilizing dryer, and sent to the filling room for later use.

[0029] Butyl rubber stopper treatment: After the butyl rubber stopper is cleaned by a rubber stopper cleaning machine, it is sterilized by steam at 121°C for 20 minutes, and dried for later use.

[0030] Aluminum-plastic cover treatment: wash the aluminum-plastic cover with an aluminum cover washing machine, sterilize, dry, and take it out for use.

[0031] Preparation of medicinal solution: Weigh the prescribed amount of mezlocillin sodium, isonicotinamide, and propyl gallate, add them to water for injection cooled to about 20°C, stir to dissolve, and circulate and filter, measure the pH of the medicinal solution to...

Embodiment 3

[0034] Embodiment 3 mezlocillin sodium freeze-dried powder injection prescription and its preparation process

[0035]

[0036] Preparation Process:

[0037] Bottle washing, sterilizing and drying: the vials are first cleaned by an ultrasonic bottle washing machine, then sterilized and dried by a sterilizing dryer, and sent to the filling room for later use.

[0038] Butyl rubber stopper treatment: After the butyl rubber stopper is cleaned by a rubber stopper cleaning machine, it is sterilized by steam at 121°C for 20 minutes, and dried for later use.

[0039] Aluminum-plastic cover treatment: wash the aluminum-plastic cover with an aluminum cover washing machine, sterilize, dry, and take it out for use.

[0040] Preparation of the medicinal solution: Weigh the prescribed amount of mezlocillin sodium, isonicotinamide, and propyl gallate, add them into water for injection cooled to 15-20°C, stir and dissolve, circulate and filter, measure the pH of the medicinal solution to...

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PUM

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Abstract

The invention discloses a mezlocillin sodium freeze-dried powder injection. The freeze-dried powder injection is prepared from mezlocillin sodium, isonicotinamide and propylgallate according to a weight ratio of 10:(0.1-0.4):(0.01-0.05). The mezlocillin sodium freeze-dried powder injection is high in stability, high in safety due to few types of auxiliary materials, simple in process and suitable for mass production.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a freeze-dried powder of mezlocillin sodium for injection and a preparation method thereof. Background technique [0002] The chemical name of mezlocillin sodium is (2S, 5R, 6R)-3,3-dimethyl-6-[(R)-2[3-(methylsulfonyl)-2-oxo- 1-imidazolidinecarboxamido]-2-phenylacetamido]-7-oxo-4-thia-1-azabicyclo[3.2.O]-heptane-2-carboxylic acid sodium salt, is a semi-synthetic Penicillin antibiotics, Pseudomonas aeruginosa, Escherichia coli, Klebsiella pneumoniae, Proteus, Enterobacter, Citrobacter, Serratia, Acinetobacter, and penicillin-sensitive Gram-positive cocci It has antibacterial effect. [0003] In the prior art, the problem of poor stability of mezlocillin sodium is solved by adding additives such as various freeze-dried proppants, metal ion chelating agents and antioxidants. Therefore, on the premise of improving the stability of the preparation, if the excipients co...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/19A61K31/431A61K47/22A61K47/14A61P31/04
CPCA61K9/0019A61K9/19A61K31/431A61K47/14A61K47/22
Inventor 卞毓平
Owner NANJING ZHENGKUAN MEDICAL TECH
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