Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Exciton-plasmon coupling system, its construction method and method for enhancing singlet oxygen generation of photosensitizer by using the coupling system

A technology of plasmonics and photosensitizers, which can be used in drug combinations, pharmaceutical formulations, wave energy or particle radiation treatment materials, etc., and can solve problems such as the lack of enhanced performance of plasmonic nanoparticles and the limitation of singlet oxygen.

Active Publication Date: 2020-03-10
THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
View PDF3 Cites 1 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the above-mentioned methods only take advantage of the property of electric field enhancement and do not give full play to the other enhancement properties of plasmonic nanoparticles, so they are still very limited in improving the production of singlet oxygen.

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Exciton-plasmon coupling system, its construction method and method for enhancing singlet oxygen generation of photosensitizer by using the coupling system
  • Exciton-plasmon coupling system, its construction method and method for enhancing singlet oxygen generation of photosensitizer by using the coupling system
  • Exciton-plasmon coupling system, its construction method and method for enhancing singlet oxygen generation of photosensitizer by using the coupling system

Examples

Experimental program
Comparison scheme
Effect test

preparation example 1

[0060] (1) Preparation of surfactant-coated gold nanorods

[0061] a, preparation of gold seed:

[0062]Under constant temperature at 30°C, take 7.5mL of 0.1M CTAB aqueous solution, add 109.2μL of 22.9mM tetrachloroauric acid aqueous solution to it, mix well, dilute the volume to 9.4mL, add under the condition of magnetic stirring 0.6 mL of sodium borohydride aqueous solution with a concentration of 0.01M (prepared temporarily before use and stored in ice water) to prepare a mixed solution (wherein the molar ratio of CTAB, sodium borohydride and tetrachloroauric acid is 300:2.4:1 ), after stirring for 3min, let stand for 2-5h to obtain a gold seed solution containing gold seeds, and the concentration of gold in the gold seed solution is 0.25mM.

[0063] b. Preparation of surfactant-coated gold nanorods:

[0064] Take 100 mL of CTAB aqueous solution with a concentration of 0.1M, add 1.96 mL of aqueous tetrachloroauric acid with a concentration of 25.5 mM, and 100 μL of an aqu...

preparation example 2

[0068] a. The preparation method and conditions of gold seed crystals are the same as step a in Preparation Example 1.

[0069] b. Take 100mL of CTAB aqueous solution with a concentration of 0.1M, add 1.96mL of tetrachloroauric acid aqueous solution with a concentration of 25.5mM, 50μL of silver nitrate aqueous solution with a concentration of 0.1M, and add 550μL of 0.1M silver nitrate solution after mixing. Ascorbic acid aqueous solution, the mixed solution changes from orange to colorless, then add 240 μL of the gold seed solution of step (a), mix well and put it in a constant temperature water bath at 30°C, after standing for 12 hours, add 0.1M gold solution three times at intervals of 30 minutes 55.2 μL of ascorbic acid was used to obtain gold nanorods coated with surfactant CTAB (abbreviated as Au640CTAB) with the LSPR peak at 640 nm.

[0070] c. Purification of gold nanorods coated with surfactant:

[0071] The solution of the gold nanorods coated with the surfactant CT...

preparation example 3

[0073] Take 50mL of the gold nanorod solution coated with the surfactant CTAB whose LSPR peak is located at 800nm ​​at a concentration of 0.5M obtained in Preparation Example 1, add 5mL of CTAB with a concentration of 0.1M, and then add 675 μL of silver nitrate with a concentration of 0.1M Aqueous solution, after shaking well, add 6.75mL of ascorbic acid with a concentration of 0.1M immediately, shake well, place the obtained growth solution in a constant temperature water bath at 70°C, and after 5 hours, obtain CTAB-coated gold rod core and silver shell with LSPR peak at 630nm Nanorods (abbreviated as Au@Ag).

[0074] Centrifuge the prepared Au@Ag rod solution at 9200rpm at 30°C for 10min, suck off the supernatant, then add deionized water equal to the volume of the sucked supernatant, and then add CTAB back into the solution. The concentration of CTAB in the solution was 1 mM, and after centrifugation under the same conditions, deionized water was added to adjust the concent...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

PropertyMeasurementUnit
wavelengthaaaaaaaaaa
wavelengthaaaaaaaaaa
Login to View More

Abstract

The invention relates to an exciton-plasma coupling system, its construction method and a method for enhancing the generation of singlet oxygen of a photosensitizer by utilizing the coupling system. The exciton-plasmon coupling system of the present invention is a core-shell structure formed by the adsorption of photosensitizer excitons and plasmonic nanoparticles, and the LSPR absorption peak of the plasmonic nanoparticles covers the excitation of the photosensitizer in the visible region. sub-absorption peaks. The method of the invention includes selecting the peak position and concentration of the plasmonic nanoparticle, the type and concentration of the charged substance, and the peak position and concentration of the photosensitizer to form a stable coupling system. Measure the singlet oxygen yield of the product by electron spin resonance technology, and determine that the coupling effect is the main factor for enhancing the singlet oxygen yield of the photosensitizer through the measurement of Raman spectroscopy. The results show that the exciton-plasmon coupling of the present invention The system has a higher singlet oxygen yield than the uncoupled system.

Description

technical field [0001] The invention belongs to the field of photosensitizer preparation and application, and relates to an exciton-plasmon coupling system, a construction method thereof and a method for enhancing the generation of singlet oxygen of a photosensitizer by using the coupling system. Background technique [0002] At present, tumor has become one of the major diseases that seriously affect human health and threaten human life. At present, the main methods for treating cancer include radiotherapy, chemotherapy, immunotherapy and surgical treatment. Photodynamic therapy (Photodynamic Therapy, PDT) is a promising tumor treatment method. PDT has been widely developed in recent years due to its low toxicity, quick effect, strong targeting, killing proliferating cells without endangering normal tissues, strong combination, and small trauma. Treatment of other diseases (Nat. Rev. Cancer 2006, 6, 535–545.). It is to kill the surrounding diseased cells by photoexciting...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
Patent Type & Authority Patents(China)
IPC IPC(8): A61K41/00A61K47/04A61K47/18A61P35/00B22F1/02B22F9/24
CPCA61K41/0071A61K47/02A61K47/18B22F9/24B22F1/17
Inventor 张会吴晓春
Owner THE NAT CENT FOR NANOSCI & TECH NCNST OF CHINA
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com