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External preparation for preventing or treating breast cancer

A kind of external preparation and breast cancer technology, which is applied in the field of medicine, can solve the problems of less breast cancer and no external treatment of breast cancer.

Inactive Publication Date: 2016-11-23
陈晓萍
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are very few research reports on the treatment of breast cancer by Spatholobus Spatholobus, and there is no report on its external use in the treatment of breast cancer.

Method used

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  • External preparation for preventing or treating breast cancer
  • External preparation for preventing or treating breast cancer
  • External preparation for preventing or treating breast cancer

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0023] The preparation of embodiment 1 Caulis Spatholobus extract

[0024] Take 250g of Caulis Spatholobus medicinal material, soak it in 70% ethanol for 40min, add 10 times the amount of 70% ethanol for ultrasonic extraction twice, each time for 40min, and combine the ultrasonic extracts. Ethanol is recovered under reduced pressure, the concentrated solution is placed in a weighed container, and then placed in a reduced-pressure freeze-drying device for 48 hours and then taken out, and the powder is collected and placed in a desiccator for later use.

Embodiment 2

[0025] The preparation of embodiment 2 Caulis Spatholobus extract

[0026] 100g of Caulis Spatholobus is decocted and extracted twice with 10 times water (W / V), 1 hour each time, the two extracts are combined, concentrated to dryness under reduced pressure, the powder is collected, and placed in a desiccator for later use.

Embodiment 3

[0027] The preparation of embodiment 3 Caulis Spatholobus extract

[0028] 1000g of Caulis Spatholobus medicinal material, ultrasonic extraction 2 times with 10 times the amount (W / V) of 60% ethanol, 1 hour each time, the two extracts were combined, concentrated under reduced pressure to no alcohol smell, then extracted with petroleum ether and acetic acid respectively Ethyl ester and n-butanol were extracted sequentially to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively.

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Abstract

The invention provides an external preparation for preventing or treating breast cancer. The external preparation comprises active ingredients and external-preparation auxiliary materials, and is characterized in that the active ingredients are prepared from caulis-spatholobi extract and / or isoliquiritigenin. The caulis spatholobi extract is aulis-spatholobi water extract and ethanol extract, or is extract prepared in the mode that caulis-spatholobi water extract and ethanol extract are extracted sequentially through petroleum ether, ethyl acetate and normal butanol or one of petroleum ether, ethyl acetate and normal butanol, or is an effective part obtained in the mode that the obtained extract is purified through a macroporous resin column. Experimental investigation shows that the caulis-spatholobi extract and / or the isoliquiritigenin have / has the effects of remarkably inhibiting breast cancer to grow and transfer in vitro and vivo, and have / has the good preventing and treating effects on breast cancer.

Description

technical field [0001] The invention relates to an external preparation, in particular to an external preparation for preventing or treating breast cancer, and belongs to the field of medicine. Background technique [0002] Spatholobus suberectus Dunn is the dried cane of the leguminous plant Spatholobus suberectus Dunn, which is a traditional Chinese medicine for nourishing blood and promoting blood circulation. In recent years, Caulis Spatholobus is commonly used clinically to treat anemia, leukocytes, platelets, red blood cells and other diseases caused by various reasons (such as radiotherapy and chemotherapy), and aplastic anemia and other diseases, and the curative effect is better. Modern pharmacological studies have proved that Spatholobus Spatholobus also has anti-tumor, anti-virus, immune regulation, two-way regulation of tyrosinase, anti-inflammatory, anti-oxidation, sedative and hypnotic effects. [0003] Regarding the anti-tumor effect of Spatholobus Spatholobu...

Claims

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Application Information

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IPC IPC(8): A61K36/486A61K31/12A61P35/00A61P15/14A61P35/04
Inventor 陈建萍高飞王能郑骁
Owner 陈晓萍
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