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Benzoylmetronidazole suspension preparation and preparation method thereof

A technology of benzoyl metronidazole and suspension preparations, which is applied in the direction of emulsion delivery, antibacterial drugs, liquid delivery, etc. It can solve the problems affecting the qualified rate of tablets and unfavorable swallowing of tablets, and achieves improvement of medication compliance, The method is simple and practical, and the effect is absorbed quickly

Inactive Publication Date: 2016-11-23
BEIJING ACTING PHARMA BIOTECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The invention prepares benzoyl metronidazole composition tablets, which are not conducive to swallowing, especially for children, and have certain requirements for the hardness and dissolution rate of the tablets, and the dosage of pharmaceutical excipients and tablet compression during the preparation process Pressure, etc. will affect the qualified rate of tablets

Method used

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  • Benzoylmetronidazole suspension preparation and preparation method thereof
  • Benzoylmetronidazole suspension preparation and preparation method thereof
  • Benzoylmetronidazole suspension preparation and preparation method thereof

Examples

Experimental program
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Effect test

Embodiment 1

[0039] In the present embodiment, the following components are included in every 1000mL of benzoyl metronidazole suspension preparation:

[0040]

[0041] The preparation method is as follows:

[0042] (1) dissolving xanthan gum in 200mL purified water to obtain a xanthan gum solution;

[0043] (2) Add benzoyl metronidazole and dispersant microcrystalline cellulose into 200 mL of purified water, stir and suspend, pour into a colloid mill, and grind until the particle size is less than 50 μm;

[0044] (3) In the stirring state, inject the ground material liquid in step (2) into the xanthan gum solution obtained in step (1), add sucralose, peach essence, sodium propionate and citric acid, and add purified water to 1000mL, stir well, fill and serve.

[0045] The benzoyl metronidazole suspension preparation obtained in this example is uniformly dispersed, has good stability, and is easy to absorb, and can be used for treating infections caused by anaerobic bacteria, reproduct...

Embodiment 2

[0047] In the present embodiment, the following components are included in every 1000mL of benzoyl metronidazole suspension preparation:

[0048]

[0049] The preparation method is as follows:

[0050] (1) dissolving xanthan gum in 100mL purified water to obtain xanthan gum solution;

[0051] (2) Add benzoyl metronidazole and the dispersant hydroxymethyl cellulose into 150 mL of purified water, stir and suspend, pour into a colloid mill, and grind until the particle size is less than 50 μm;

[0052] (3) In the stirring state, inject the ground material liquid in step (2) into the xanthan gum solution obtained in step (1), add sucralose, strawberry essence, sodium propionate and citric acid, and add purified water to 1000mL , stir well, and fill it.

[0053] The benzoyl metronidazole suspension preparation obtained in this example is uniformly dispersed, has good stability, and is easy to absorb, and can be used for treating infections caused by anaerobic bacteria, reproduct...

Embodiment 3

[0055] In the present embodiment, the following components are included in every 1000mL of benzoyl metronidazole suspension preparation:

[0056]

[0057]

[0058] The preparation method is as follows:

[0059] (1) dissolving xanthan gum in 250mL purified water to obtain xanthan gum solution;

[0060] (2) Add benzoyl metronidazole and dispersant microcrystalline cellulose into 300mL of purified water, stir and suspend, pour into a colloid mill, and grind until the particle size is less than 50 μm;

[0061] (3) Under stirring, inject the ground material liquid in step (2) into the xanthan gum solution obtained in step (1), add sucralose, banana essence, sodium propionate and citric acid, and add purified water to 1000mL , stir well, and fill it.

[0062] The benzoyl metronidazole suspension preparation obtained in this example is uniformly dispersed, has good stability, and is easy to absorb, and can be used for treating infections caused by anaerobic bacteria, reproduc...

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Abstract

The present invention provides a kind of benzoyl metronidazole suspension preparation and preparation method thereof, the following components are included in the described per 1000mL benzoyl metronidazole suspension preparation: 40-70g benzoyl metronidazole, 2-8g xanthan Glue, 1-4g sweetener, 1-5g dispersant, 0.1-0.5g fruit essence, 0.1-3g stabilizer and the balance purified water. The present invention can make the insoluble benzoylmetronidazole form a stable suspension in water through the selection of the raw material components in the benzoylmetronidazole suspension preparation, which is easy to absorb and can be easily absorbed in the gastrointestinal tract. The distribution area is large, the absorption is fast, the bioavailability is high, and it is not as difficult to swallow as a tablet, which improves the patient's medication compliance, and is suitable for children to take, safe and effective. It can be used for treating diseases caused by anaerobic bacteria, reproductive system trichomoniasis, gingivitis, etc., and has remarkable effect, and the preparation method of the invention is simple and suitable for industrial production.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations and relates to a benzoyl metronidazole suspension preparation and a preparation method thereof. Background technique [0002] Benzoyl metronidazole suspension is suitable for various anaerobic infections, such as sepsis, endocarditis, empyema, lung abscess, abdominal infection, pelvic infection, gynecological infection, bone and joint infection, meningitis, brain abscess , skin and soft tissue infection, antibiotic-associated enteritis caused by Clostridium difficile, Helicobacter pylori-associated gastritis or peptic ulcer, periodontal infection and Gardner's vaginitis, etc. It can also be used as a preventive drug for some polluting or potentially polluting operations, such as elective colorectal surgery. It can also be used to treat intestinal and parenteral amoebiasis (such as amoebic liver abscess, thoracic amoebiasis, etc.), vaginal trichomoniasis, balanomiasis, cutaneous leishman...

Claims

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Application Information

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IPC IPC(8): A61K9/10A61K31/4164A61K47/36A61K47/12A61P31/04
CPCA61K9/10A61K31/4164A61K47/12A61K47/36
Inventor 程雪翔
Owner BEIJING ACTING PHARMA BIOTECH
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