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Preparation method for liquid adhesive bandage

A technology of liquid bandages and chitosan, which is applied in the field of medicine, can solve the problems of liquid bandages with general film-forming properties, unsatisfactory effects, and limited performance of active ingredients in medicines, so as to achieve ideal application prospects, facilitate healing, and prevent further The effect of infection

Inactive Publication Date: 2016-11-16
李康
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are two core problems in liquid bandages: first, the setting of the membrane components; second, the effectiveness of the drug components, and the synergy with the membrane
[0006] Known from above-mentioned technical scheme, this scheme is with polyvinyl alcohol, chitosan, dioctyl phthalate and laurocapram as film-forming material, with nude flower purple pearl as medicinal composition, and the film-forming of whole liquid bandage The performance is average, the active ingredients of the drug have limited performance, and the effect is not ideal in actual use

Method used

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  • Preparation method for liquid adhesive bandage
  • Preparation method for liquid adhesive bandage
  • Preparation method for liquid adhesive bandage

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] A preparation method of a liquid bandage, comprising the steps of:

[0028] Step 1: Modified chitosan, take 300g of chitosan and 600g of polyvinyl acetate into the reactor, add 600g of deionized water, stir for 1h, then add 100g of N-methyl-N-vinylacetamide 100g of polylactic acid-glycolic acid copolymer, 200g of carboxymethyl cellulose and 400g of glycerin were stirred evenly by ultrasonic at 65°C to obtain modified chitosan;

[0029] Step 2: Take 3200g gardenia, 2500g cork, 2000g honeysuckle, 2400g Magnolia officinalis, 2200g Fangfeng, 2700g Ophiopogon japonicus, 2600g forsythia, 2500g anemarrhena, 2800g clove, 4300g chuanxiong, and grind them to a powder with an average particle size of 2mm , put it into a container, add 50Kg of distilled water, and impregnate for 4 days at a temperature of 55°C to obtain an impregnating liquid and impregnating slag;

[0030] The 3rd step, filter the impregnation solution obtained through filter paper three times to obtain a clarifi...

Embodiment 2

[0034] A preparation method of a liquid bandage, comprising the steps of:

[0035] Step 1, modified chitosan, take 800g of chitosan and 1200g of polyvinyl acetate into the reactor, add 1000g of deionized water, stir for 1h, then add 300g of N-methyl-N-vinylacetamide , polylactic acid-glycolic acid copolymer 300g, carboxymethyl cellulose 500g and glycerin 1000g, at 65 ℃, ultrasonically stirred to obtain modified chitosan;

[0036] Step 2: Take 3200g gardenia, 2500g cork, 2000g honeysuckle, 2400g Magnolia officinalis, 2200g Fangfeng, 2700g Ophiopogon japonicus, 2600g forsythia, 2500g anemarrhena, 2800g clove, 4300g chuanxiong, and grind them to a powder with an average particle size of 2mm , put it into a container, add 50Kg of distilled water, and impregnate for 4 days at a temperature of 55°C to obtain an impregnating liquid and impregnating slag;

[0037] The 3rd step, filter the impregnation solution obtained through filter paper three times to obtain a clarified filtrate, ...

Embodiment 3

[0041] A preparation method of a liquid bandage, comprising the steps of:

[0042] Step 1: Modified chitosan, put 600g of chitosan and 1000g of polyvinyl acetate into the reactor, add 900g of deionized water, stir for 1h, then add 200g of N-methyl-N-vinylacetamide , polylactic acid-glycolic acid copolymer 200g, carboxymethyl cellulose 300g and glycerin 600g, at 67 ℃, ultrasonically stirred to obtain modified chitosan;

[0043] Step 2: Take 2000g Gardenia, 1500g Cortex Phellodendri, 1500g Honeysuckle, 1800g Magnolia Officinalis, 1000g Fangfeng, 1800g Ophiopogon japonicus, 1500g Forsythia 1500g, 1800g Anemarrhena, 1600g Clove, 2800g Chuanxiong, and pulverize it to a powder with an average particle size of 3mm , put it into a container, add 30Kg of distilled water, and after immersion for 3 days, the immersion temperature is 55°C to obtain the immersion liquid and immersion slag;

[0044] The 3rd step, filter the impregnation solution obtained through filter paper three times to...

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Abstract

The invention discloses a preparation method for a liquid adhesive bandage, belonging to the field of medical technology. The preparation method comprises the following steps: step 1, preparing modified chitosan; step 2, soaking cape jasmine, phellodendron bark, honeysuckle flower, magnolia cortex, divaricate saposhnikovia root, tuber of dwarf lilyturf, Fructus Forsythiae, Rhizoma Anemarrhenae, clove and Ligusticum wallichii; step 3, preparing a concentrate; step 4, carrying out reflux extraction with ethanol so as to obtain extract; and step 5, uniformly mixing the concentrate with the extract, adding modified chitosan and alginate, and carrying out uniform mixing under stirring so as to obtain the liquid adhesive bandage. The liquid adhesive bandage prepared in the invention has excellent film forming ability, exerts ideal bleeding-stopping, pain-relieving, sterilizing, anti-inflammatory and secondary infection-preventing effect, is nonirritant to the skin, does not lead to allergy of the skin, better facilitates healing of wounds and shows good application prospect.

Description

technical field [0001] The invention discloses a preparation method of a liquid bandage, which belongs to the technical field of medicine. Background technique [0002] Band-aid is the most commonly used surgical drug in people's life. Band-aid has the function of stopping bleeding and protecting creativity. Traditional band-aids are generally strip-shaped adhesive plasters with a drug layer in the middle, and are generally used for emergency treatment of small traumas, thereby temporarily stopping bleeding and protecting the wound surface. Ordinary bandages should not be used for too long. If you use them for too long, the outer layer of the bandage will be airtight, which will make the wound and the skin around the wound turn white and soften, leading to secondary infection of bacteria and exacerbating the deterioration of the wound. [0003] In addition, some wounds recover slowly, and it is difficult to achieve better results by using traditional wound dressings for ...

Claims

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Application Information

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IPC IPC(8): A61L26/00
CPCA61L26/0066A61L26/0023A61L26/0057A61L2300/30A61L2300/404A61L2300/41A61L2300/418C08L5/04C08L5/08
Inventor 李康
Owner 李康
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