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Method for preparing hederagenin from soapberries

A technology of hedera saponin and Sapindus chinensis, applied in the field of preparation of hedera saponin, achieving the effect of short steps and easy operation

Inactive Publication Date: 2016-11-09
FUZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] The present invention aims to overcome the deficiencies of the prior art and provide a simple, efficient, energy-saving and environmentally friendly preparation method for hedera saponin, so as to solve the problem of large-scale industrial preparation of high-purity hedera saponin

Method used

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  • Method for preparing hederagenin from soapberries
  • Method for preparing hederagenin from soapberries

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A method for preparing helexin from Sapindus chinensis, comprising the following steps:

[0035] 1) Add a certain amount of deionized water to absolute ethanol to obtain an ethanol aqueous solution with a volume concentration of 80%, which is the extraction solution;

[0036] 2) Take out the seeds of the Chinese medicinal material Sapindus chinensis, dry and pulverize the pericarp to obtain Sapindus chinensis powder, add the Sapindia chinensis powder into the above extraction solution according to the ratio of solid to liquid 1:6kg / L for reflux extraction, and reflux extraction The temperature is 80°C, reflux extraction for 4 hours until the extraction is complete to obtain the extract, the extract is cooled, filtered and the filtrate is collected, and the filtrate is concentrated to 5% of the original volume to obtain a syrupy extract;

[0037] 3) Add deionized water six times the weight of the extract and an equal volume of sulfuric acid solution with a concentration ...

Embodiment 2

[0041] A method for preparing helexin from Sapindus chinensis, comprising the following steps:

[0042] 1) preparing an aqueous methanol solution with a volume concentration of 70% as the extraction solution;

[0043]2) Take out the seeds of the Chinese medicinal material Sapindus chinensis, dry and pulverize the pericarp to obtain Sapindus chinensis powder, add the Sapindia chinensis powder into the above extraction solution according to the ratio of solid to liquid 1:8 kg / L for reflux extraction, reflux The extraction temperature is 70°C, reflux extraction for 6 hours until the extraction is complete to obtain the extract, the extract is cooled, filtered and the filtrate is collected, and the filtrate is concentrated to 3% of the original volume to obtain a syrupy extract;

[0044] 3) Add deionized water 8 times the weight of the extract and an equal volume of sulfuric acid solution with a concentration of 3 mol / L to the above extract, hydrolyze it in a water bath at 60°C fo...

Embodiment 3

[0047] A method for preparing helexin from Sapindus chinensis, comprising the following steps:

[0048] 1) Prepare an aqueous ethanol solution or an aqueous methanol solution with a volume concentration of 60% as the extraction solution;

[0049] 2) Take out the seeds of the Chinese medicinal material Sapindus chinensis, dry and pulverize the pericarp to obtain Sapindus chinensis powder, add the Sapindia chinensis powder into the above extraction solution according to the ratio of solid to liquid 1:10 kg / L for reflux extraction, reflux The extraction temperature is 50°C, reflux extraction for 8 hours until the extraction is complete to obtain the extract, the extract is cooled, filtered and the filtrate is collected, and the filtrate is concentrated to 0.5% of the original volume to obtain a syrupy extract;

[0050] 3) Add deionized water 9 times the weight of the extract and an equal volume of sulfuric acid solution with a concentration of 2 mol / L to the above extract, hydrol...

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Abstract

The invention provides a method for preparing hederagenin from soapberries. The method comprises the steps that soapberry total saponin is extracted through an ethanol-water mixture solvent, hydrolysis is carried out and crystallization process purification is carried out to obtain the hederagenin. The method for preparing hederagenin is high in yield, simple in operation, mild in condition, low in cost, free of pollution and environmentally friendly. By means of the method for preparing hederagenin, high-purity hederagenin can be obtained, the production cost is lower compared with the prior art, the yield is greatly improved, the application prospect is wide, and the requirements of rapidly-developed medical industry can be met.

Description

technical field [0001] The invention relates to the technical field of extracting medicinal and active ingredients from natural plants, in particular to a method for preparing hedera saponin from Sapindus chinensis. technical background [0002] Research data shows that hedera saponin has functions such as antidepressant, weight loss, blood lipid lowering, and blood sugar lowering (see patent 1: CN 101214250A; patent 2: CN 101564405A; patent 3: CN 02109763.1; patent 4: CN 101125880A), so how Obtaining this compound easily, efficiently and at low cost has become the focus of attention. The content of hedera saponin in most plants is relatively low, and it mostly exists in the form of saponins. Therefore, if this compound is produced industrially and in large quantities, the basic idea is to first extract the total saponins from plants with higher content, and then It is converted into aglycone by acid hydrolysis, and finally high-purity hedera saponin is obtained by crystall...

Claims

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Application Information

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IPC IPC(8): C07J63/00
CPCC07J63/008
Inventor 欧敏锐许小平祝令辉谷俊杰
Owner FUZHOU UNIV
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