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Ocular preparation for preventing and treating cataract and preparation method of ocular preparation

An ophthalmic preparation, cataract technology, applied in the directions of non-active ingredients medical preparations, medical preparations containing active ingredients, pharmaceutical formulas, etc., can solve the loss of adjustment ability, reduce the severity of cataracts, and ophthalmic preparations have not been reported. And other issues

Active Publication Date: 2016-11-09
CGENETECH (SUZHOU CHINA) CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Patients with early and mid-term cataracts can be treated with drugs, but there is no possibility of a complete cure at present. They often wait until the mature stage to recover their vision through surgery to remove the cloudy lens. Loss of ability, and there is the possibility of multiple complications, so seeking effective preventive drugs is the top priority
[0005] (3β)-8,24-lanostadien-3-ol, commonly known as lanosterol, is one of the lanolin-type tetracyclic triterpenoids, the English name is lanosterol, and the CAS number is 79-63-0 , whose chemical name is 3β-Hydroxy-8,24-Lanostadiene, recently found that administration of lanosterol-containing eye drops to dogs with cataracts for 6 weeks can reduce the severity of cataracts and improve the clarity of the lens, indicating that lanosterol may have similar Compounds with active molecules can provide another therapeutic means for the treatment of cataracts, but ophthalmic preparations related to lanosterol have not been reported

Method used

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  • Ocular preparation for preventing and treating cataract and preparation method of ocular preparation
  • Ocular preparation for preventing and treating cataract and preparation method of ocular preparation
  • Ocular preparation for preventing and treating cataract and preparation method of ocular preparation

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1 to 5、 comparative example 1

[0085] Examples 1 to 5, Comparative Example 1: Refer to Table 1 for the raw material formula of lanosterol eye drops. The preparation method is as follows: weigh lanosterol and add it to a surfactant, and stir to make it fully included. Weigh the preservative and dissolve it in water for injection. Add the preservative aqueous solution to the lanosterol mixture and stir to dissolve. Autoclave, 115°C, 30min.

[0086] Table 1

[0087]

Embodiment 6 to 10、 comparative example 2

[0088] Examples 6 to 10, Comparative Example 2: Refer to Table 2 for the raw material formula of lanosterol eye ointment. The preparation method is as follows: weigh lanosterol, matrix, isotonic regulator, and some antioxidants, melt them on a water bath, and heat to 75°C. Separately weigh the surfactant, remaining antioxidant and preservative, dissolve in part of the water for injection, and heat to 75°C. Slowly add to the oil phase, stir while adding, add the remaining water for injection, and mix well.

[0089] Table 2

[0090]

[0091]

Embodiment 11 to 15、 comparative example 3

[0092] Examples 11 to 15, Comparative Example 3: Refer to Table 3 for the raw material formula of lanosterol gel. The preparation method is as follows: add the matrix to water for injection to moisten and swell, add preservative, and stir to dissolve. Add lanosterol to the surfactant and stir to dissolve. Then slowly add the lanosterol solution into the matrix solution, stir and mix evenly.

[0093] table 3

[0094]

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PUM

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Abstract

The invention relates to an ocular preparation for preventing and treating cataract and a preparation method of the ocular preparation. The ocular preparation comprises in weight percentage, 0.1%-10% of lanostane tetracyclic triterpenoid compounds and 90%-99.9% of auxiliary materials. The ocular preparation is stable in quality and simple and convenient in preparation process, and pharmacodynamic evaluation is performed.

Description

technical field [0001] The invention relates to an ophthalmic preparation for preventing and treating cataract and a preparation method thereof. Background technique [0002] Can cause lens metabolism disorder, resulting in lens protein denaturation and opacity, called cataract. Most cataracts are a disease of old age, but children are born with them, and others develop after injury, inflammation, or illness. [0003] According to the incomplete statistics of the World Health Organization, there are about 16 to 21 million cataract blind people in the world. Cataract generally has a slow course of disease and is the most common and dangerous ophthalmic disease. It is easy to cause damage to the eyes or even blindness if it is not treated in time or prevented. [0004] Cataract treatment includes two aspects, one is drug treatment, and the other is surgical treatment. Patients with early and mid-term cataracts can be treated with drugs, but there is no possibility of a comp...

Claims

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Application Information

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IPC IPC(8): A61K31/575A61K9/00A61P27/12
CPCA61K47/32A61K47/36A61K47/38A61K47/44A61P27/12A61K9/0048A61K9/06A61K9/08A61K31/575
Inventor 潘慧平余强丁炬平
Owner CGENETECH (SUZHOU CHINA) CO LTD
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