Looking for breakthrough ideas for innovation challenges? Try Patsnap Eureka!

Triamcinolone acetonide nasal spray with thixotropy and preparation method thereof

A nasal spray and thixotropic technology, applied in the field of pharmaceutical preparations, can solve problems such as uneven drug mixing and poor drug uniformity, and achieve the effects of increasing viscosity, improving stability, and stable performance

Active Publication Date: 2016-11-09
LIAONING UNIVERSITY
View PDF4 Cites 5 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The existing triamcinolone acetonide aqueous suspension nasal spray has no thixotropy, white particles precipitate after standing, and a milky white suspension is formed after shaking, which has the defects of poor drug uniformity and uneven drug mixing after shaking

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Triamcinolone acetonide nasal spray with thixotropy and preparation method thereof
  • Triamcinolone acetonide nasal spray with thixotropy and preparation method thereof
  • Triamcinolone acetonide nasal spray with thixotropy and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] (1) The formula is as follows

[0026]

[0027] (2) The preparation method is as follows

[0028] 1) Triamcinolone acetonide micronization: Put the triamcinolone acetonide raw material into a jet mill for micronization; particle size: after triamcinolone acetonide micronization, the content of particles with a particle size of less than 15μm is greater than 90%, and the maximum particle size must not exceed 50μm, ready to use after the fineness is qualified.

[0029] 2) Dissolve the prescription amount of compound suspending agent (by weight ratio, microcrystalline cellulose: sodium carboxymethyl cellulose = 89:11) in deionized water (about 60% of the total deionized water), and use High-speed homogenizer, at 12kr / min, high-speed shearing and stirring for 10 minutes, to obtain A;

[0030] 3) Dissolve the prescription amount of Tween-80 in deionized water (approximately 10% of the total deionized water), a part of which is used to disperse the prescription amount of triamcinolo...

Embodiment 2

[0036] (1) The formula is as follows

[0037]

[0038] (2) Preparation method: same as in Example 1.

Embodiment 3

[0040] (1) The formula is as follows

[0041]

[0042] (2) Preparation method: same as in Example 1.

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

PUM

No PUM Login to View More

Abstract

The invention relates to a triamcinolone acetonide nasal spray with thixotropy and a preparation method thereof. The triamcinolone acetonide nasal spray is prepared from, by weight, 0.01%-0.1% of triamcinolone acetonide, 0.5%-2.0% of a compound suspending aid, 0.005%-0.01% of a wetting agent, 4%-6% of an osmotic pressure regulator, 0.010%-0.025% of a preservative, 0.001%-0.05% of a complexing agent, a pH regulating agent enabling the system pH to be kept at 4.5 to 5.5 and deionized water. According to the triamcinolone acetonide nasal spray with the thixotropy and the preparation method thereof, the technological process is simple, convenient to operate and reliable, the prepared nasal spray has the thixotropy, the uniformity of the drugs in the suspension preparation is good, and the nasal spray has the good spreadability when the nasal spray is used and is used for treating allergic rhinitis.

Description

Technical field [0001] The invention relates to a pharmaceutical preparation, in particular to a triamcinolone acetonide nasal spray with thixotropy and a preparation method thereof. Background technique [0002] Thixotropy refers to a kind of rheology in which the viscosity or shear force of some systems changes with time under agitation or other mechanical action. Under the action of external shear force, the viscosity of the system decreases with time, and gradually recovers after being stationary. The thixotropic fluid forms a network structure inside the fluid due to the physical agglomeration or electrostatic attraction of the internal molecules. Under the action of external force, the microscopic network structure changes with the shear time, and the macroscopically shows shear thinning Or shear thickening phenomenon. [0003] Triamcinolone acetonide (CAS: 76-25-5) is a potent topical glucocorticoid, the drug of choice for the treatment of seasonal, perennial and allergic ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to View More

Application Information

Patent Timeline
no application Login to View More
IPC IPC(8): A61K9/12A61K31/58A61K47/38A61K47/18A61K47/14A61K47/26A61P11/02A61P37/08
Inventor 陈烨任翠莹李文军王洋
Owner LIAONING UNIVERSITY
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Patsnap Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Patsnap Eureka Blog
Learn More
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com