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Culture medium of hericium erinaceus, bio-converted mycelium, extract of the bio-converted mycelium, and application of the extract

A technology of biotransformation and Hericium erinaceus, applied to fertilizers made of biological waste, medical preparations containing active ingredients, applications, etc., can solve problems such as limited treatment methods and inability to treat thoroughly, and achieve good anti-tumor effects Effect

Inactive Publication Date: 2016-11-02
HUNAN XINHUI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chemotherapy is the most commonly used method, although it cannot completely cure
In the past few decades, the development of molecular biology has made some progress in the treatment of gastric cancer, but drug resistance and toxicity still limit the progress of treatment methods

Method used

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  • Culture medium of hericium erinaceus, bio-converted mycelium, extract of the bio-converted mycelium, and application of the extract
  • Culture medium of hericium erinaceus, bio-converted mycelium, extract of the bio-converted mycelium, and application of the extract
  • Culture medium of hericium erinaceus, bio-converted mycelium, extract of the bio-converted mycelium, and application of the extract

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0034] A kind of extract of biotransformation mycelia, its preparation method comprises the steps:

[0035] (1) Take 490g of agricultural and sideline products wheat bran, 140g of corn flour, 63g of rice bran, 7g of sugar, and 300g of Chinese herbal medicine Scutellaria barbata (Scutellaria barbata) , mix well, add 500g of water and mix well to get Hericium erinaceus culture medium. Then bottle, sterilize, insert Hericium erinaceus, transform and cultivate at 27°C for 40 days, take out the mycelium, and dry it to obtain the biotransformed mycelium;

[0036] (2) Take the biotransformed mycelium, soak it in water at 60° C. for 2 times, soak for 2 hours each time, the weight of the water is 6 times the weight of the biotransformed mycelium, and obtain the extract;

[0037] (3) Concentrate the extract obtained after extraction under reduced pressure, and vacuum-dry the concentrated solution obtained by concentrating under reduced pressure at 60° C. to obtain the extract.

Embodiment 2

[0039] A kind of extract of biotransformation mycelia, its preparation method comprises the steps:

[0040] (1) Take 420g of agricultural and sideline products wheat bran, 120g of corn flour, 54g of rice bran, 6g of sugar, and 400g of Chinese herbal medicine Scutellaria barbata (Scutellaria barbata) , mix well, add 500g of water and mix well to get Hericium erinaceus bottling, sterilizing, inserting Hericium erinaceus, transforming and culturing at 20°C for 40 days, taking out the mycelium, and drying to obtain the biotransformed mycelium;

[0041] (2) Take the biotransformed mycelium, soak it in water at 60° C. for 3 times, each time for 3 hours, the weight of the water is 8 times the weight of the biotransformed mycelium, and obtain the extract;

[0042] (3) Concentrate the extract obtained after extraction under reduced pressure, and vacuum-dry the concentrated solution obtained by concentrating under reduced pressure at 60° C. to obtain the extract.

Embodiment 3

[0044] A kind of extract of biotransformation mycelia, its preparation method comprises the steps:

[0045] (1) Take 350g of wheat bran, 100g of corn flour, 45g of rice bran, 5g of sugar, and 500g of Chinese herbal medicine Scutellaria barbata (Scutellaria barbatae), mix well, add 500g of water and mix well to get Hericium erinaceus The culture medium; then bottled, sterilized, inserted into Hericium erinaceus, transformed and cultured at 25°C for 30 days, taken out the mycelium, and dried to obtain the biotransformed mycelium;

[0046] (2) Take the biotransformed mycelium, soak it in water at 60° C. for 3 times, soak for 4 hours each time, and the weight of the water is 10 times the weight of the biotransformed mycelium to obtain an extract;

[0047] (3) Concentrate the extract obtained after extraction under reduced pressure, and vacuum-dry the concentrated solution obtained by concentrating under reduced pressure at 60° C. to obtain the extract.

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Abstract

The invention discloses a culture medium of hericium erinaceus, a bio-converted mycelium, an extract of the bio-converted mycelium, and an application of the extract. The culture medium is prepared by adding a traditional Chinese medicine, sculellaria barbata, to a base culture medium and includes the base culture medium and the sculellaria barbata. 100 parts of the culture medium includes 50-70 parts of the base culture medium and 30-50 parts of the sculellaria barbata, wherein the base culture medium includes, by weight, 350-490 parts of wheat bran, 100-140 parts of corn flour, 45-63 parts of grain bran, 5-7 parts of white sugar and 400-600 parts of water. The bio-converted mycelium is a product that is prepared by inoculating the hericium erinaceus on the culture medium through mycelium conversion. The extract of the bio-converted mycelium is prepared by water-extracting and then pressure-reduced-concentrating the hericium erinaceus mycelium and finally performing vacuum freeze-drying. The extract of the bio-converted mycelium has the effect of resisting gastrointestinal cancer, wherein the effect is significantly better than that of the hericium erinaceus mycelium and the sculellaria barbata independently, so that the extract can be used for preparing an anti-gastrointestinal cancer medicine.

Description

technical field [0001] The invention relates to the technical field of biopharmaceuticals, in particular to a culture medium of Hericium erinaceus, a biotransformation mycelium, an extract of the biotransformation mycelium and uses thereof. Background technique [0002] Hericium erinaceus, a mushroom (fungi) of the family Hericium erinaceae, has been used in traditional Chinese medicine to treat gastrointestinal diseases for more than 2,000 years. A series of small molecule compounds, such as erinacines, are believed to have nerve regeneration and can pass through The blood-brain barrier repairs damaged nervous tissue. Hericium erinaceus also has anti-ulcer, anti-inflammatory, anti-microbial, immune regulation, improving liver function, anti-aging, lowering blood sugar and blood lipids, improving anti-hypoxia ability, increasing cardiac output, and improving circulation, etc., including Hericium erinaceus The medical preparations of are widely used in China. [0003] The m...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C05G3/00A61K36/07A61P35/00A01G1/04
CPCC05G3/00A01G18/00A61K36/07A61K2236/331A61K2236/39A61K2236/51C05F5/002C05F11/00
Inventor 何述金周代俊周邦维
Owner HUNAN XINHUI PHARMA
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