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Antihypertensive peptide and application thereof

A blood pressure-lowering peptide and a blood pressure-lowering technology, applied in the blood pressure-lowering peptide and its application field, can solve the problems of increasing blood urea nitrogen and creatinine, restricting the use of hypertensive patients, etc.

Active Publication Date: 2016-10-26
JILIN AGRICULTURAL UNIV
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AI Technical Summary

Problems solved by technology

Although this type of ACE inhibitory drugs can lower blood pressure clinically, they also bring many side effects, such as neurogenic edema, renal sclerosis, hypokalemia, etc., especially have adverse effects on patients with impaired renal function, which can cause blood urea Nitrogen and creatinine increases, limiting use in hypertensive patients

Method used

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  • Antihypertensive peptide and application thereof
  • Antihypertensive peptide and application thereof
  • Antihypertensive peptide and application thereof

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Embodiment Construction

[0010] The following examples are to further illustrate the present invention, rather than limit the present invention.

[0011] 1. Experimental Materials and Instruments

[0012] YLVR (purity 80%, synthesized by Beijing Zhongke Yaguang Biotechnology Co., Ltd.), captoril (Captoril), spontaneously hypertensive rats (Spontaneously hypertensive rats, SHR) 9-10 weeks, weighing 220-270 grams , SPF grade, purchased from Beijing Weitong Lihua Experimental Animal Technology Co., Ltd.

[0013] 2 Experimental method:

[0014] 2.1 Grouping of rats

[0015] The temperature of the raising environment for the rats is 22°C±1°C, the relative humidity is 60%±5%, the light time is 12 hours a day, and light and darkness are alternated. The lighting time is from 7:30 to 19:30. Before carrying out the test, the rats need a week to adapt to the new environment, single-cage feeding, free access to food and water, standard feed feeding, and daily tracking and statistics of food intake and water i...

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Abstract

Antihypertensive peptide and application thereof belong to the technical field of antihypertensive peptides; the antihypertensive peptide has an amino acid sequence of YLVR (Lyr, Leu, Val and Arg). Animal experiments discover that antihypertensive peptide YLVR is antihypertensive for a spontaneously hypertensive rat (SHR), has no significant effect on the weight of the SHR, has no significant effect on the heart rate of the SHR, has no effect on the normal growth of the rat, and may be referenced for synthesis of hypertension therapeutics for preparing antihypertensive drugs.

Description

technical field [0001] The invention belongs to the technical field of hypotensive peptides, in particular to a hypotensive peptide and its application. Background technique [0002] Angiotensin-converting enzyme-I (ACE, EC 3.4.15.1) is a Zn-containing 2+ Carboxydipeptidase of the prosthetic group is a key enzyme of the renin-angiotensin-aldosterone system (RAS), which converts angiotensin I into angiotensin II through hydrolysis, and at the same time, ACE can also blunt Bradykinin, both of which can lead to vasoconstriction, which can lead to high blood pressure. Therefore, ACE is considered to be an important factor causing hypertension. According to the structure-activity relationship, the design of small molecules to replace AngI and combine with the active center of ACE is the design principle of antihypertensive drugs. Captopril is an ideal ACE inhibitor designed by people, and on this basis, enalapril and lisinopril are further synthesized, which are currently the ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07K5/107A61K38/07A61P9/12
CPCA61K38/00C07K5/1016
Inventor 闵伟红刘春雷李鸿梅方丽王辑
Owner JILIN AGRICULTURAL UNIV
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