Prediction method for organs at risk average dosage in intensity modulated radiation therapy and application thereof

Abstract

The invention discloses a method for predicting the average dose of organs at risk in intensity-modulated radiotherapy, comprising the following steps: 1) Obtaining the functional relationship formula between Vox / Vx and Dmx / Dp, wherein, Vx is the volume of organs at risk, and Vox is The intersection volume of the organ at risk and the planned target area, Dp is the prescribed dose, and Dmx is the average dose of the organ at risk; 2) The average dose of the organ at risk is predicted by the functional relationship formula. The specific application of this prediction method includes the following steps: A) determine Dp; B) obtain the average dose Dmx1 of the relevant organs at risk according to the functional relationship formula between Vox / Vx and Dmx / Dp obtained by the prediction method; C) carry out simulation adjustment Strong optimization, get the average dose Dmx2; D) Compare Dmx1 and Dmx2; E) When Dmx2≤Dmx1, meet the standard; Dmx2>Dmx1, continue to optimize the intensity modulation. The invention is easy to collect data, conveniently establishes an organ-at-risk prediction model suitable for corresponding departments' treatment planning systems and equipment, and reduces the influence of subjective factors in the optimization process of radiotherapy plans.

Description

technical field [0001] The invention relates to the technical field of medical radiation therapy, in particular to a method for predicting the average dose of organs at risk in intensity-modulated radiotherapy and specific applications of the prediction method. Background technique [0002] At present, the most important treatment methods for malignant tumors include surgery, chemotherapy and radiation therapy. Especially for patients with advanced cancer, radiation therapy accounts for a large proportion; and among radiation therapy methods, nearly two One of the most widely used treatment methods at home and abroad in the past ten years is intensity-modulated radiotherapy. [0003] Intensity-modulated radiation therapy, that is, intensity-modulated conformal radiation therapy, is a kind of three-dimensional conformal radiation therapy, which requires the dose intensity in the radiation field to be adjusted according to certain requirements, referred to as intensity-modulat...

AI Technical Summary

Problems solved by technology

However, in the actual IM optimization process, due to the influence of optimization methods, means, and human factors, most radiotherapy centers control organs at risk within a limited range, but due to the lack of effective prediction methods, the final absorbed dose to organs at risk depends more on Based on the experience of each radiotherapy unit, subjective factors have a great influence on the optimization process of radiotherapy plan

[0005] The existing prediction method is to establish a prediction model for intensity-modulated radiotherapy by extracting the dose information of each sampling point of organs at risk in the treatment plan, and use this model to predict the dose-volume curve of organs at risk before making an intensity-modulated radiotherapy plan. Guarantee the quality of intensity-modulated radiotherapy plan, but the prediction method is relatively complicated and requires high requirements for related equipment, so it is difficult to be widely and specifically applied in the preparation of intensity-modulated radiotherapy plan

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