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Application of desmodium styracifolium extract in urinary calculus

A technology of Desmodium sativa and its extract, which is applied in the field of medicine to achieve the effects of reducing the deposition of calcium oxalate crystals in kidney tissue, reducing the calcium content of kidney tissue, and reducing the damage of kidney pathological tissue

Inactive Publication Date: 2016-10-05
SHANGHAI NATURE STANDARD R&D & BIOTECH +2
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AI Technical Summary

Problems solved by technology

The use of Chinese herbal medicine to treat kidney stones has significant effects and few side effects. Therefore, in recent years, there have been more and more researches on the anti-stone aspect of Chinese medicine. At present, there has been no report on the effect of extracting parts of Desmodium sativa on alleviating crystallized kidney damage.

Method used

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  • Application of desmodium styracifolium extract in urinary calculus
  • Application of desmodium styracifolium extract in urinary calculus
  • Application of desmodium styracifolium extract in urinary calculus

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Experimental program
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Embodiment 1

[0050] 1. Preparation of Desmodium sativa extract:

[0051] Take Desmodium sativa as raw material, pulverize, and extract with 95% ethanol aqueous solution or heat reflux extraction, the solid-liquid ratio of said scutellaria sativa to 95% ethanol aqueous solution is 1g: (5 ~ 13) ml, and the ethanol aqueous solution is combined The extract is concentrated until there is no alcohol smell to obtain a concentrate. After the extract is concentrated, the concentration of alcohol without alcohol taste is less than 10%.

[0052] Then the obtained concentrated solution is dispersed with water, and petroleum ether, ethyl acetate and n-butanol are respectively used as extraction solvents for extraction. The volume ratio between the concentrated solution and the extraction solvent is 1:1 to 1:3, and the number of extractions is 1-3. times to obtain the extract. Then, each extract was concentrated to obtain petroleum ether fractions, ethyl acetate fractions, n-butanol fractions, and ext...

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Abstract

The invention belongs to the technical field of medicines, and particularly relates to application of desmodium styracifolium extract in urinary calculus. Three positions of desmodium styracifolium are extracted, and the effect of each part on calcium oxalate crystal is studied by adopting a mouse calcium oxalate crystal model which is manufactured by injecting a glyoxylate solution into the peritoneal cavity. Results indicate that the desmodium styracifolium extract can be used for promoting the serum creatinine and urea nitrogen content of a mouse to be remarkably reduced, the calcium content of kidneys to be remarkably reduced, the calcium oxalate crystal deposition in kidney tissues and kidney pathological tissue injury to be remarkably alleviated, the levels of CAT, CuZn-SOD, GSH, osteopontin, CD44, TRPV5, Calbindin-D28 and Ki67 to be remarkably increased, and the content of MDA and TUNEL to be remarkably reduced.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to the application of Desmodium sativa extract in treating urinary calculus. Background technique [0002] The kidney is an important functional organ of the human body. Its function is to remove metabolites, wastes, and poisons in the body while producing urine, and retain water and other useful substances in the body through the reabsorption function, such as protein, glucose, amino acids, potassium ions, Sodium ions, sodium bicarbonate, etc., regulate water, electrolyte balance and acid-base balance in the body, and the kidneys ensure the stability of the internal environment of the body so that the metabolism can proceed normally. Urinary calculus is an important disease that endangers human health. my country is a high-incidence area for calculi in the world, and the incidence rate is increasing year by year. With the development of medical technology, although th...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/185A61K36/53A61P13/04A61P13/12
CPCA61K36/185A61K36/53A61K2300/00
Inventor 钱勇谌卫董昕郭志勇娄子洋辛振强张田勇谢天培
Owner SHANGHAI NATURE STANDARD R&D & BIOTECH
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