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Application of total saponins of panax japonicus in preparation of ulcerative colitis resisting medicines

A technology for total saponins of Panax ginseng and ulcerative colitis, which is applied in the application field of total saponins of Panax ginseng in the preparation of anti-ulcerative colitis medicines, and can solve problems such as no one has studied it.

Inactive Publication Date: 2016-09-28
CHONGQING MEDICAL & PHARMA COLLEGE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Whether bamboo ginseng strengthens the spleen and stomach, astringent intestines and relieves diarrhea is the pharmacological basis for the treatment of ulcerative colitis, no one has yet studied

Method used

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  • Application of total saponins of panax japonicus in preparation of ulcerative colitis resisting medicines
  • Application of total saponins of panax japonicus in preparation of ulcerative colitis resisting medicines
  • Application of total saponins of panax japonicus in preparation of ulcerative colitis resisting medicines

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0024] 1. Establishment of experimental ulcerative colitis animal model

[0025] 1 Experimental materials

[0026] 1.1 Experimental animals:

[0027] Clean-grade Kunming mice (male), weighing 22-25 grams, were provided by the Experimental Animal Center of Chongqing Medical University.

[0028] 1.2 Main reagents and medicines:

[0029] Dextran sulfate sodium salt MW: 36000-50000 (MP Biomedicals, USA)

[0030] Fecal occult blood kit (Nanjing Jiancheng Bioengineering Institute)

[0031] 1.3 Main instruments:

[0032] Electronic balance

[0033] A2000S Electronic Analytical Balance (Sartorius, Germany)

[0034] Sigma-3k cryogenic centrifuge (Sigma, USA)

[0035] -80℃ ultra-low temperature refrigerator (Germany)

[0036] UV-225 UV-Vis Spectrophotometer (Japan)

[0037] BH-2 optical microscope (Olympus, Japan)

[0038] 1.4 Preparation of solution:

[0039] 0.5% sodium carboxymethylcellulose.

[0040] Preparation of 4% DSS aqueous solution: Weigh 40g of DSS and dissolve i...

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Abstract

The invention discloses an application of total saponins of panax japonicus in preparation of ulcerative colitis resisting medicines. According to the application, the prevention and treatment action and action mechanism of the total saponins of panax japonicus to dextran sulfate sodium induced mouse ulcerative colitis are researched through a series of tests, i.e., extracting the total saponins of panax japonicus, carrying out an acute toxicity test on the total saponins of panax japonicus, modeling a mouse acute ulcerative colitis model and observing the therapeutic action of the total saponins of panax japonicus on ulcerative colitis, and the influence on NF-[kappa]B and PPAR-gamma signal channels caused by the total saponins of panax japonicus is disclosed for the first time. The total saponins of panax japonicus have the effects of treating both symptoms and root causes and being safe and effective during the treatment of the ulcerative colitis.

Description

technical field [0001] The invention relates to the field of medicines, in particular to the application of total saponins of bamboo ginseng in the preparation of anti-ulcerative colitis medicines. Background technique [0002] Ulcerative colitis (UC) is an idiopathic intestinal inflammatory disease characterized by chronic, recurrent attacks with unknown etiology. The morbidity and prevalence of the disease have a clear increasing trend in our country. The etiology of ulcerative colitis has not yet been fully elucidated. It is mainly a chronic nonspecific inflammatory disease that invades the colonic mucosa and progresses gradually in a continuous manner. The clinical manifestations of UC are mushy and soft stools, often mixed with pus and blood, pain in the lower abdomen, and bloody diarrhea or bloody stools in severe cases. The etiology and pathogenesis of UC have not yet been elucidated, and it may be related to various factors such as immune abnormalities, intestinal ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/258A61K31/7048A61P1/00A61P1/04
CPCA61K36/258A61K31/7048A61K2236/331A61K2236/39A61K2236/51A61K2236/53A61K2236/55
Inventor 邓庆华唐倩陈先玉刘晓颖蒋红艳苏湲淇郑小红
Owner CHONGQING MEDICAL & PHARMA COLLEGE
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