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Glucose SERS detection substrate based on ag@ag nanodot hierarchical galaxy array and preparation method thereof

A nano-dot and glucose technology, applied in the field of glucose SERS detection substrate and its preparation, can solve the problems of difficult adjustment of surface nanostructure parameters, high cost, low yield, etc., achieve significant surface Raman enhancement effect, and ensure Raman signal , the effect of good uniformity

Inactive Publication Date: 2019-02-22
SHANGHAI UNIV
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  • Abstract
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  • Claims
  • Application Information

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Problems solved by technology

Many researchers have done a lot of work and proposed preparation methods such as electron beam lithography, focused-ion-beamlithography, and nanosphere-assisted lithography. It is difficult to adjust the structural parameters of surface nanostructures, and the further application of SERS technology is restricted due to low yield and high cost

Method used

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  • Glucose SERS detection substrate based on ag@ag nanodot hierarchical galaxy array and preparation method thereof
  • Glucose SERS detection substrate based on ag@ag nanodot hierarchical galaxy array and preparation method thereof
  • Glucose SERS detection substrate based on ag@ag nanodot hierarchical galaxy array and preparation method thereof

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Embodiment 1

[0034] Example 1: In this example, the glucose SERS detection substrate of the Ag@Ag nano-dot hierarchical galaxy array containing the mother particle and the daughter particle two-level array was prepared on the UTAM after two times of high and low temperature expansion, and two times of vacuum thermal resistance deposition on the UTAM , the preparation process is as figure 1 shown. The specific operation is as follows: First, the aluminum sheet with a thickness of 0.2 mm and a purity of 99.999% is ultrasonically cleaned in acetone, ethanol, and water for 10 min, and then the aluminum sheet is placed in a solution of ethanol and perchloric acid and carried out in an ice bath. Electrochemical polishing to prepare a spare aluminum sheet. Oxidize the spare aluminum sheet in 0.3 M oxalic acid at 40 V and 2 °C for 10 h, take it out, and put it in a mixed solution of 1.8w% chromic acid and 6w% phosphoric acid with a volume ratio of 1:1, at a temperature of 60 °C Soak in water for...

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Abstract

The invention relates to a glucose SERS detection substrate based on a Ag@Ag nanodot hierarchical galaxy array and a preparation method thereof. The glucose SERS detection substrate is prepared by depositing on the surface of a silicon substrate the Ag@Ag nanodot hierarchical galaxy array containing a two-stage structure composed of a silver nanodot mother particle array and a silver nanodot son particle array. Silver nanodot mother particles have diameters in a range of 91 to 97 nm; silver nanodot son particles on and around the silver nanodot mother particles have diameters in a range of 3 to 12 nm; and the center distance of adjacent silver nanodot mother particles is in a range of 98 to 102 nm. The glucose SERS detection substrate based on the Ag@Ag nanodot hierarchical galaxy array is controllable in structure, high in the coupling degree of galaxy structures, substantially improved in Raman signals and uniform and stable in enhancing signals; and SERS test results show that the glucose SERS detection substrate strongly responds to glucose concentration. The method provided by the invention realizes flexible regulation and control of the sizes of the mother particles and the son particles, can more easily realize large-scale, high-sensitivity and low-cost preparation and is capable of realizing performance advantages of the SERS substrate in biological detection of glucose and the like.

Description

technical field [0001] The invention relates to a glucose SERS detection substrate based on an Ag@Ag nano-dot hierarchical galaxy array and a preparation method thereof. In particular, an Ag@Ag nanodot hierarchical galaxy array glucose detection substrate based on ultra-thin alumina template (UTAM) surface nanofabrication technology and its preparation method. Background technique [0002] In recent decades, with the continuous development of modern living standards, factors such as nutrient-rich diet and reduced exercise have led to an increase in the incidence of diabetes year by year. Diagnosis and detection of diseases such as diabetes has always troubled the whole human being, and Surface Enhanced Raman Scattering (Surface Enhanced Raman Scattering, SERS) technology has been widely used in chemistry, environment and Biology, especially medical sensing and detection, is developing very rapidly. [0003] How to design and prepare the SERS detection substrate structure s...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): G01N21/65
CPCG01N21/658
Inventor 付群雷勇吴东旭耿飞王聿曦
Owner SHANGHAI UNIV
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