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Ampeloptin medicine composition and application thereof to biological medicine

A technology of astragalus and its composition, which is applied in the pharmaceutical composition and its application field in biomedicine, can solve the problems that have not been reported related to prostatic hyperplasia of astragalus, and achieve the effect of improving the therapeutic effect

Inactive Publication Date: 2016-09-21
ZIBO KUAKE MEDICINE TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] So far, there has been no report on the correlation between astragalus and its pharmaceutical composition and benign prostatic hyperplasia

Method used

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  • Ampeloptin medicine composition and application thereof to biological medicine
  • Ampeloptin medicine composition and application thereof to biological medicine
  • Ampeloptin medicine composition and application thereof to biological medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1: Compound (I) Separation Preparation and Structure Confirmation

[0018] Separation method: (a) Grind Pterocephala (2kg), extract with 90% ethanol under heat reflux (15L×3 times), combine the extracts, concentrate until no alcohol smell (3L), and then use petroleum ether (3L×3 times), ethyl acetate (3L × 3 times) and water-saturated n-butanol (3L × 3 times) were extracted to obtain petroleum ether extract, ethyl acetate extract and n-butanol extract respectively; (b) step ( a) Use D101 type macroporous resin to remove impurities from the ethyl acetate extract in the medium, first elute with 35% ethanol for 8 column volumes, then use 90% ethanol to elute for 12 column volumes, collect 90% eluent, and depressurize Concentrate to get 90% ethanol elution concentrate; (c) in step (b), 90% ethanol elution concentrate is separated with normal phase silica gel, and the volume ratio is 120:1 (11 column volumes), 60:1 ( 9 column volumes), 30:1 (9 column volumes) and 15...

Embodiment 2

[0022] Embodiment 2: pharmacological action

[0023] In this embodiment, Kunming mice were castrated, and sc testosterone propionate 5 mg kg for 3 consecutive weeks -1 d -1 , build a model of benign prostatic hyperplasia, and observe the therapeutic effect of drugs on benign prostatic hyperplasia.

[0024] 1. Materials and methods

[0025] 1.1 Animals

[0026] Mice, Kunming species, male, 20-23 g, 80 mice, were provided by the Experimental Animal Center of Hebei Province.

[0027] 1.2 Reagents and samples

[0028]Albatin is self-made and its structure has been verified. Compound (I) is self-made, and the preparation method is shown in Example 1. Pentobarbital Sodium, China National Pharmaceutical Group Shanghai Chemical Reagent Company; Penicillin Sodium for Injection, North China Pharmaceutical Co., Ltd.; Testosterone Propionate Injection, Shanghai General Pharmaceutical Co., Ltd.; Longbishu Capsule, Shijiazhuang Kedi Pharmaceutical Co., Ltd. Company; mouse testosteron...

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Abstract

The invention discloses an ampeloptin medicine composition and application thereof to biological medicine. The provided ampeloptin medicine composition contains ampeloptin and a natural product compound (I) with a novel structure; when the ampeloptin and the compound (I) singly act, prostatic hyperplasia can be treated; when the ampeloptin and the compound (I) act in a combined way, the treatment effect on the prostatic hyperplasia is further improved, and medicine for treating the prostatic hyperplasia can be developed. Compared with the prior art, the ampeloptin medicine composition has prominent substantial characteristics and obvious progress.

Description

technical field [0001] The invention belongs to the field of biomedicine and relates to the new application of astragalus, in particular to a pharmaceutical composition of astragalus and its application in biomedicine. Background technique [0002] Prostatic hyperplasia (BPH) is one of the common diseases of middle-aged and elderly men, and its incidence is increasing with the aging of the global population. The incidence of benign prostatic hyperplasia increases with age, but there may not be clinical symptoms when there are hyperplasia lesions. The urban incidence rate is higher than that in the rural areas, and racial differences also affect the degree of proliferation. [0003] So far, there is no report on the correlation between astragalus and its pharmaceutical composition and benign prostatic hyperplasia. Contents of the invention [0004] The purpose of the present invention is to provide a pharmaceutical composition of astragalus, which contains astrasin and a ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07D311/96A61K31/352A61P13/08
CPCC07D311/96A61K31/352A61K36/185
Inventor 高忠青
Owner ZIBO KUAKE MEDICINE TECH
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