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Application of periplaneta americana in preparation of drug for preventing and treating radiation-induced damage

A technology of Periplaneta americana and medicine, which is applied in the field of medicine, can solve problems such as the application of Periplaneta americana powder and its extract, and achieve obvious prevention and treatment effects, obvious curative effect, and the effect of preventing skin damage

Inactive Publication Date: 2016-09-21
SICHUAN GOODDOCTOR PANXI PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] At present, there is no application of Periplaneta americana powder and its extract in radiotherapy

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0028] Example 1 Periplaneta americana Extract

[0029] Coarsely crush 1000kg of dried Periplaneta americana, add 4 times the amount of 70% ethanol, soak for 1 hour, and extract twice at a temperature of 70°C for 8 hours for the first time; add 3 times the amount of ethanol for the second time, extract for 6 hours and combine Secondary extract, filter, when the filtrate is concentrated to a clear paste with a relative density of 1.09-1.16 (70°C), add water, keep stirring at 70°C for 60 minutes, let stand for 12 hours, discard the upper layer of grease, filter the lower layer of liquid medicine, The ethanol was recovered from the filtrate, concentrated under reduced pressure to a medicinal solution (70° C.) with a relative density of 1.16 to 1.22, and the Periplaneta americana extract was obtained.

Embodiment 2

[0030] Embodiment 2 Periplaneta americana medicinal powder

[0031] Weigh 10kg of Periplaneta americana adults cultured in the GAP base and place it in an ultra-low temperature pulverizer set at -160°C to pulverize to 200 mesh; then add 90kg of purified water to make a suspension, and in an environment of 20°C, mix the Put the suspension into the ultra-high pressure homogenizer, carry out ultra-high pressure homogenization at a pressure of 90MPa for 15 minutes, and perform 4 consecutive cycles to obtain a homogeneous liquid; the homogeneous liquid is spray-dried at 35°C, and the measured After the water content is 2.7%, then add 0.1 kg of fumed silicon dioxide and mix well to obtain the Periplaneta americana medicinal powder.

[0032] Detected according to JY / T001-1996 "General Principles of Transmission Electron Microscopy", the particle size of 85% of the particles in the obtained Periplaneta americana medicinal powder is in the range of 20-80nm, which fully meets the academ...

Embodiment 3

[0034] Embodiment 3 Periplaneta americana medicinal powder

[0035] Weigh 20kg of Periplaneta americana adults cultured in the GAP base and place it in an ultra-low temperature pulverizer set at -190°C to pulverize to 200 mesh; then add 120kg of purified water to make a suspension, and in an environment of 15°C, the prepared Put the suspension into the ultra-high pressure homogenizer, carry out ultra-high pressure homogenization at a pressure of 100MPa for 30 minutes, and perform 3 consecutive cycles to obtain a homogeneous liquid; the homogeneous liquid is spray-dried at 60°C, and the measured The water content is 3.1%, then 5g of fumed silicon dioxide is added and mixed evenly to obtain the Periplaneta americana medicinal powder.

[0036] Detected according to JY / T001-1996 "General Principles of Transmission Electron Microscopy", the particle size of 85% of the particles in the obtained Periplaneta americana medicinal powder is in the range of 20-80nm, which fully meets the ...

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PUM

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Abstract

The invention provides application of periplaneta americana powder or a periplaneta americana extract in preparation of a drug for preventing and treating radiation-induced damage. The drug is used for preventing and treating damage caused by radiotherapy conducted on a nasopharynx cancer, an esophagus cancer, an esophageal cancer, a gastric cancer, a lung cancer, a liver cancer, a breast cancer, Webster's lymphoma and other cancers, and especially has the obvious effect of preventing and treating the damage caused by the radiotherapy to patients suffering from the breast cancer. It is found through research that the drugs can effectively prevent radioactive skin damage to mice.

Description

technical field [0001] The invention belongs to the field of medicine, and in particular relates to the application of Periplaneta americana in the preparation of medicines for preventing and treating radiotherapy damage. Background technique [0002] Radiation therapy is one of the most commonly used treatments for malignant tumors, and clinically most tumor patients will receive radiation therapy. However, due to the obvious aggressiveness of radiation to the human body and the poor specific selection function for tumor cell killing, radiation inevitably damages surrounding tissues and normal cells while killing tumor cells, causing a series of systemic and local damage to the body. Toxic and side effects, so no matter psychologically or physically, it has caused different degrees of harm to patients. [0003] The main side effects of radiotherapy are: (1) nasopharynx, oral mucosa and skin injury; (2) heart radiation injury; (3) radiation pneumonitis; (4) radiation bone m...

Claims

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Application Information

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IPC IPC(8): A61K35/64A61P39/00A61P17/00A61P17/16
CPCA61K35/63
Inventor 耿福能
Owner SICHUAN GOODDOCTOR PANXI PHARMA
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