A bioresponsive targeted dual-drug sustained-release carrier material and preparation method thereof
A slow-release carrier and responsive target technology, which can be used in pharmaceutical formulations, drug delivery, medical preparations with inactive ingredients, etc. The effect of good biological responsiveness
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Embodiment 1
[0039] A method for preparing a bioresponsive targeted dual-drug slow-release carrier material, comprising the following steps:
[0040](1) Synthesis of RAFT reagents:
[0041] a. Dissolve 2.5g KOH in 2.5mL H 2 Obtain KOH solution in O; Dissolve 10.1g dodecanethiol and 0.64g tetrabutylammonium bromide in 25mL acetone, then mix it with KOH solution;
[0042] b. Slowly add 2.6mL of carbon disulfide to the mixed solution obtained in step (a) dropwise, stir for 30 minutes, add 5mL of chloroform to it, and stir for another 10min; place the solution at 0°C, and add dropwise while stirring KOH solution (12.0g KOH dissolved in 10mL H 2 O), after the dropwise addition was completed, it was placed at room temperature and stirred overnight;
[0043] c. Add 60 mL of deionized water to the solution obtained in step (b), then add 10 mL of concentrated hydrochloric acid for acidification; the resulting product is vacuum-dried to obtain a solid product; recrystallized with isopropanol, and...
Embodiment 2
[0055] A method for preparing a bioresponsive targeted dual-drug slow-release carrier material, comprising the following steps:
[0056] (1) Synthesis of RAFT reagent: same as Example 1;
[0057] (2) Synthesis of PDSEMA:
[0058] (3) Preparation of amphiphilic single-chain polymer: Dissolve 90mg of RAFT reagent, 7g of PDSEMA, 4g of polyethylene glycol methacrylate (Mw 500) and 10mg of AIBN in 10mL of DMF, and use the freeze-thaw pump circulation method to purify and remove Gas more than 3 times; then seal the reaction mixture, put it into a preheated 70 ℃ oil bath for 12h; 5mL of dichloromethane, and then re-precipitated in 20mL of ether to obtain unreduced amphiphilic polymer single chain;
[0059] (4) Preparation of amphiphilic polymer nanospheres: Dissolve 10 mg of amphiphilic polymer single chain in 200 μL of acetone, slowly add DTT dropwise therein; stir for 10 minutes, add 1 mL of deionized water, and then stir overnight at room temperature , in contact with the air, ...
Embodiment 3
[0063] A method for preparing a bioresponsive targeted dual-drug slow-release carrier material, comprising the following steps:
[0064] (1) Synthesis of RAFT reagent: same as Example 1;
[0065] (2) Synthesis of PDSEMA:
[0066] (3) Preparation of amphiphilic polymer single chain: Dissolve 90mg of RAFT reagent, 5g of PDSEMA, 4g of polyethylene glycol methacrylate (Mw 500) and 10mg of AIBN in 10mL of DMF, and use the freeze-thaw pump circulation method to purify and remove Gas more than 3 times; then seal the reaction mixture, put it into a preheated 70 ℃ oil bath for 12h; 5mL of dichloromethane, and then re-precipitated in 20mL of ether to obtain unreduced amphiphilic polymer single chain;
[0067] (4) Preparation of amphiphilic polymer nanospheres: Dissolve 10 mg of amphiphilic polymer single chain in 200 μL of acetone, slowly add DTT dropwise therein; stir for 10 minutes, add 1 mL of deionized water, and then stir overnight at room temperature , in contact with the air, ...
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