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Thermo-sensitive polymer-based hollow fiber and hollow microsphere as well as preparation method and application thereof

A temperature-sensitive polymer and polymer technology, applied in the manufacture of hollow filaments, single-component synthetic polymer rayon, fiber chemical characteristics, etc., can solve the problems of slow response rate, limited use effect, large size, etc.

Active Publication Date: 2018-07-06
SICHUAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

At present, most of them are applied in the form of hydrogel, and the disadvantages of large size and slow response rate limit their use effect

Method used

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  • Thermo-sensitive polymer-based hollow fiber and hollow microsphere as well as preparation method and application thereof
  • Thermo-sensitive polymer-based hollow fiber and hollow microsphere as well as preparation method and application thereof
  • Thermo-sensitive polymer-based hollow fiber and hollow microsphere as well as preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0038] 1. Preparation of temperature sensitive polymer (poly N-isopropyl acrylamide / N-methylol acrylamide / acrylamide polymer):

[0039] Add 20 parts of acrylamide, 70 parts of N-isopropylacrylamide, and 10 parts of N-methylolacrylamide into deionized water. The reaction materials (acrylamide+N-isopropylacrylamide+N-methylolpropylene) The total concentration of amide) is 20wt%. After the raw materials are completely dissolved, the initiator potassium persulfate is added (the quality of the initiator is one percent of the weight of the raw materials), and the prepolymerization is carried out in a water bath at 0°C for 4h (avoid N- Isopropylacrylamide self-crosslinking), and then reacted in an environment at a temperature of 60℃ for 6h to obtain a poly-N-isopropylacrylamide polymer solution; then dialysis treatment for 48h, changing the deionized water every 12 hours ; Finally, freeze-drying to obtain a water-soluble temperature-sensitive polymer-poly N-isopropyl acrylamide / N-methyl...

Embodiment 2

[0045] 1. Preparation of temperature-sensitive polymer (poly N-isopropylacrylamide / isobutoxy methacrylamide / acrylic acid polymer):

[0046] Add 10 parts of acrylic acid, 80 parts of N-isopropyl acrylamide, and 10 parts of isobutoxy methacrylamide into dimethylformamide. The reaction materials (acrylic acid + N-isopropyl acrylamide + isobutyl The total concentration of oxymethacrylic acid amine) is 16wt%. When the reaction raw materials are completely dissolved, add the initiator ammonium persulfate (the initiator accounts for 3% of the total mass of the reaction raw materials), and place it in a water bath at -5°C. Prepolymerize for 3h (to avoid self-crosslinking of N-isopropylacrylamide), then react for 8h in an environment at a temperature of 50℃ to obtain a polymer solution (poly N-isopropylacrylamide polymer solution); then dialyze Treated for 96 hours, change the deionized water every 12 hours; finally freeze-dry to obtain a water-soluble temperature-sensitive polymer—poly N...

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Abstract

The invention belongs to the field of macromolecules and relates to a thermo-sensitive polymer-based hollow fiber and hollow microspheres as well as a preparation method and application thereof. The preparation method of the thermo-sensitive polymer-based hollow fiber and or hollow microspheres comprises the following steps: preparing a homogeneous solution as an external spinning liquid from a water-soluble poly N-isopropyl acrylamide polymer, preparing a homogeneous solution as an internal spinning liquid from an anti-cancer medicine, and preparing the thermo-sensitive polymer-based hollow fiber and or hollow microspheres with the thermo-sensitive polymer as a shell layer and the anti-cancer medicine as a core layer from the external spinning liquid and the internal spinning liquid by using a coaxial electrostatic spinning method. The thermo-sensitive polymer-based hollow fiber and or hollow microspheres provided by the invention can be used as a cancer medicine carrier, medicines can be completely wrapped by the carrier, and the purpose of zero medicine release in transportation can be achieved; when reaching an affected part, medicines inside cavities can be released by virtueof volume shrinkage of the thermo-sensitive material at a high temperature, then a targeting release effect can be achieved, and the defects of medicine chemotherapy treatment on cancer can be overcome.

Description

Technical field [0001] The invention belongs to the technical field of polymer materials, and specifically relates to a temperature-sensitive polymer-based hollow fiber, hollow microspheres, and a preparation method and application thereof. Background technique [0002] Cancer has become a major disease that seriously endangers human health and life. As the most commonly used method for cancer treatment-drug chemotherapy, while killing tumor cells, it will also seriously affect the normal cells of the human body. The side effects caused greatly limit its effect in cancer treatment. Therefore, if the drug only acts on tumor cells and does not damage normal cells during drug chemotherapy, it will become an excellent method for treating cancer. For this reason, the drug delivery and action process must meet: 1. Zero release during drug delivery before reaching the location of the lesion; 2. Targeting sustained and controlled release of the drug after reaching the patient's location...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C08F220/54C08F220/56C08F220/58C08F220/06A61K47/32A61K9/50A61K9/00D01F1/08D01F6/28
Inventor 王孝军卫志美杨杰张刚龙盛如
Owner SICHUAN UNIV
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