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Application of lithium chloride to preparation of methamphetamine cognitive disorder medicament

A technology for methamphetamine and cognitive impairment, which is applied in the field of medicine and can solve the problems of no relevant reports, little research and application of cognitive behavioral effects

Inactive Publication Date: 2016-09-07
NINGBO UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0005] However, at present, lithium chloride is mainly used clinically in the treatment of mental disorders such as mania, while there are few studies and applications in the field of addiction, and there is no correlation between lithium chloride and its influence on cognitive behavior after methamphetamine addiction. to report

Method used

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  • Application of lithium chloride to preparation of methamphetamine cognitive disorder medicament
  • Application of lithium chloride to preparation of methamphetamine cognitive disorder medicament
  • Application of lithium chloride to preparation of methamphetamine cognitive disorder medicament

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] Example 1 Establishment of Methamphetamine Intravenous Self-administration Model

[0018] Intravenous Drug Self-Administration (Intravenous Drug Self-Administration) is one of the most classic animal models for studying drug addiction. Drug motivation and active compulsive drug use.

[0019] The classic methamphetamine methamphetamine self-administration model in rats can well simulate the methamphetamine smoking behavior of clinical drug addicts. Rats can self-administer p-methamphetamine after training. The rising behavioral response rate and dosage of methamphetamine can reflect the process of drug users from the initial exposure to methamphetamine to the addiction of heavy use of methamphetamine.

[0020] We used the following methods to establish a self-administration model in rats:

[0021] Firstly, SD rats underwent jugular vein cannulation operation, a section of PE tube was inserted into the right jugular vein, and passed out of the body through the back, ant...

Embodiment 2

[0027] Embodiment 2 Cognitive function detection

[0028] 2.1 Establishment of water maze detection model

[0029]The Morris water maze was used as a test model of spatial learning and memory in rats. The Morris water maze video analysis system detects the spatial learning and memory of rats. The Morris water maze test starts within 24 hours after the end of ECT treatment. The Morris water maze is divided into 4 quadrants: Ⅰ, Ⅱ, Ⅲ, and Ⅳ. Tap water was filled in the water maze, and ink was added to make it turbid. Before the test, the platform was placed 2 cm below the water surface of the quadrant. All experiments were carried out between 9:00am and 3:00pm, the room was quiet, the items were placed and the lights were in the same state, and the water temperature was (24±1)°C. Morris1.0 software tracks and records and analyzes relevant data.

[0030] (1) Positioning and sailing test: Positioning and sailing test was carried out on the first to sixth days: put the rats into...

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Abstract

The invention relates to application of lithium chloride to preparation of a methamphetamine cognitive disorder medicament. The experiments of the invention prove that a treatment effect of the lithium chloride on the methamphetamine cognitive disorder is reflected to show that the lithium chloride can serve as a new medicament for improving methamphetamine cognitive disorder by observing that methamphetamine has an inhibit effect on learning and memory of a rat, while the lithium chloride has an obvious promoting effect on the learning and memory of a mouse which is addicted to amphetamines in a water maze test of the lithium chloride on the mouse which is addicted to methamphetamines.

Description

technical field [0001] The invention relates to a new application of lithium chloride, in particular to the application of lithium chloride in post-methamphetamine cognitive and behavioral disorders, and belongs to the technical field of medicine. Background technique [0002] Methamphetamine (METH), commonly known as ice, is a white amphetamine-like synthetic drug. High-dose or long-term repeated users will suffer from mental illnesses, including depression, mania, schizophrenia, etc., and severe cases will cause toxic psychosis, manifested as persecution delusions and hallucinations, overuse and even suicidal and homicidal tendencies. During the withdrawal period of methamphetamine, methamphetamine addicts will experience mental and emotional changes such as insomnia, depression, mania, and anxiety, and these withdrawal reactions have also become the main physiological factors affecting the relapse of methamphetamine addicts (Wang Wei et al. 2012). Therefore, the principl...

Claims

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Application Information

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IPC IPC(8): A61K33/14A61P25/28A61P25/36
CPCA61K33/14
Inventor 潘俭刘昱李鹏平黎兴兴毛紫娟
Owner NINGBO UNIV
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