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Compositions comprising a viola herba extract, or an extract of viola herba, persicae semen, cinnamomi ramulus, and glycyrrhiza spp. for the prevention or treatment of lipid-related cardiovascular diseases and obesity

A technology of Radix vulgaris and a composition is applied in the field of food additive composition for preventing lipid-related cardiovascular disease or obesity, and the extract can solve problems such as adverse reactions, weight gain and the like, achieve weight reduction, cholesterol reduction, Effects of preventing or treating cardiovascular disease or obesity

Inactive Publication Date: 2016-08-31
KOREA INST OF ORIENTAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, these drugs can induce adverse effects such as cardiovascular disease (such as high blood pressure) and stroke, and weight gain often begins once the drug is stopped

Method used

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  • Compositions comprising a viola herba extract, or an extract of viola herba, persicae semen, cinnamomi ramulus, and glycyrrhiza spp. for the prevention or treatment of lipid-related cardiovascular diseases and obesity
  • Compositions comprising a viola herba extract, or an extract of viola herba, persicae semen, cinnamomi ramulus, and glycyrrhiza spp. for the prevention or treatment of lipid-related cardiovascular diseases and obesity
  • Compositions comprising a viola herba extract, or an extract of viola herba, persicae semen, cinnamomi ramulus, and glycyrrhiza spp. for the prevention or treatment of lipid-related cardiovascular diseases and obesity

Examples

Experimental program
Comparison scheme
Effect test

preparation Embodiment 1

[0079] Preparation Example 1. Preparation of Extract

[0080] Viola didin was purchased from Omniherb Co. (Daegu, Korea), and extracted via hot water extraction by adding 10 volumes of water. Peach kernels, cinnamon sticks and licorice were purchased from Kwangmyungdang Medicinal Herbs (Ulsan, Korea). The dried herbal material was mixed in a weight ratio of 3:2:2 among peach kernel, cassia twig and licorice, and extracted via hot water extraction. The extracts of Viola, peach kernel, cassia twig and Glycyrrhiza were obtained by using water as the extraction solvent, extracting the extracts containing Viola viola, peach kernel, cassia twig in a weight ratio of 1:3 (25wt%: 75wt%) Combination mixture with a mixture of licorice.

Embodiment 1

[0081] Example 1. Construction of high-fat diet (HFD)-induced animal model

[0082] Male C57bl / 6 mice were used after purchase from the Jackson Laboratory (Bar Harbor, Maine, USA). Among them, healthy 10-week-old mice underwent maintenance experiments under specific pathogen-free (SPF) conditions, and they were allowed to take food and water freely. After purchasing a high-fat diet (HFD) consisting of protein (20%), carbohydrates (20%) and fat (60%) from Central Lab.Animal Inc. (Seoul, Korea) (Rodent diet D12492, Research Diets, New Brunswick, NJ, USA) to use it afterwards.

[0083] Experimental animals were acclimated to basic diet (AIN-76A diet) for two weeks, and then co-administered HFD diet and herbal medicines for 7 weeks from 8 weeks of age. There are 6 groups in the experimental group, including: the normal group (normal diet) administered with normal saline and fed with normal feed, the control group (HFD) administered with saline and fed with HFD, and the positiv...

Embodiment 2

[0084] Embodiment 2. Viola extract, or the extract of Viola, peach kernel, osmanthus twig and Glycyrrhiza have effect on reducing body weight and depression effect on food intake

[0085] The body weight and the amount of feed intake of the experimental animals were measured using an electronic scale (GP5202, Sartorius, Germany), analyzed, and the feed efficiency ratio (EFR) was calculated based on the ratio of body weight gain to the amount of feed intake.

[0086] The HFD group administered Viola Viola extract (HFD - Viola Viola) -compared to the HFD-Control group - showed a decrease in their body weight from 11 weeks of age onwards. HFD group administered with extracts of viola, peach kernel, cassia twig, and licorice (HFD- Viola + (peach kernel, cassia twig, licorice)) -compared with the group administered viola extract alone- - showed a significant reduction in their weight gain (pfigure 1 ).

[0087] [Table 1]

[0088]

[0089] ###: p<0.001 vs normal diet

[00...

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Abstract

The present invention relates to a pharmaceutical or a food additive composition comprising a Viola Herba extract, or an extract of Viola Herba, Persicae Semen, Cinnamomi Ramulus, and Glycyrrhiza spp. for the prevention or treatment of lipid-related cardiovascular diseases or obesity, and a method for the treatment of lipid-related cardiovascular diseases or obesity comprising administering the pharmaceutical composition to a subject in need of the same. The Viola Herba extract, or the extract of Viola Herba, Persicae Semen, Cinnamomi Ramulus, and Glycyrrhiza spp. of the present invention is shown to be effective in reducing body weight, body fat, total cholesterol in blood, and lowering blood pressure, and thus can be used for effective prevention or treatment of lipid-related cardiovascular diseases or obesity.

Description

technical field [0001] The present invention relates to a composition comprising Viola Herba extract, or Viola Herba, Persicae Semen, Cinnamomi Ramulus and Glycyrrhiza for the prevention or treatment of lipid-related cardiovascular disease or obesity. spp.), and to a method for preventing lipid-related cardiovascular disease or obesity, the method comprising administering the pharmaceutical composition to a subject in need thereof. [0002] In addition, the present invention relates to a food additive composition comprising Viola extract, or extracts of Viola, peach kernel, Guizhi and Glycyrrhiza for preventing or improving lipid-related cardiovascular disease or obesity. Background technique [0003] Dietary fat intake has continued to increase among Korean adults over the past decade. According to the Korean National Health & Nutrition Examination Survey, the prevalence of obesity determined by body mass index (BMI) in 2010 was 36.3% for men and 24.8% for women. Specific...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/86A61K36/736A61K36/54A61K36/484
CPCA61K36/484A61K36/54A61K36/736A61K36/86A61P3/00A61P3/04A61K2300/00A61K36/00A61K39/36
Inventor 成尹映金镐京金东善崔高也
Owner KOREA INST OF ORIENTAL MEDICINE
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