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Water-soluble powder of cyclodextrin clathrate of quinocetone and preparation method thereof

A technology of quinocetone cyclodextrin and water-soluble powder, applied in the field of pharmaceutical preparations, can solve the problems of low bioavailability, poor absorption, poor dispersion and the like, and achieve the effects of high bioavailability, good solubility and improved water solubility

Inactive Publication Date: 2016-08-24
CHINA ANIMAL HUSBANDRY IND
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0008] The purpose of the present invention is to aim at the shortcomings of existing quinocetone and its premix products such as insolubility in water, low bioavailability, poor absorption and poor fluidity, and provide the market with a simple preparation, high dissolution rate, good solubility, Water-soluble powder preparation of veterinary drug quinocetone cyclodextrin inclusion complex with high bioavailability and good absorption and preparation method thereof

Method used

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  • Water-soluble powder of cyclodextrin clathrate of quinocetone and preparation method thereof

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Effect test

Embodiment 1

[0016] According to quinocetone:cyclodextrin:water=10:30~50:50~100 (mass percentage), weigh raw materials, adopt saturated aqueous solution method to prepare quinocetone clathrate, and its specific preparation steps are:

[0017] (1) Add 400g of β-cyclodextrin in proportion to the corresponding 1000g of water, stir and heat up;

[0018] (2) Continue to stir, heat up to about 80°C, add 100g of quinocetone, and make it mix evenly;

[0019] (3) Then control the temperature at about 80°C, continue stirring, and keep warm for 45 minutes;

[0020] (4) After the heat preservation is completed, the obtained material is poured into a baking tray and spread evenly, and put into an oven for continuous drying for 4 hours at a drying temperature of 95-105° C. to obtain a powdery quinocetone clathrate;

[0021] (5) cooling, crossing 60 mesh sieves with the cooled powdered quinocetone cyclodextrin inclusion compound;

[0022] (6) Sampling of the inclusion compound of quinone cyclodextrin t...

Embodiment 2

[0024] According to quinocetone:cyclodextrin:water=10:30~50:50~100 (mass percentage), weigh raw materials, adopt saturated aqueous solution method to prepare quinocetone clathrate, and its specific preparation steps are:

[0025] (1) Add 320g of α-cyclodextrin in proportion to the corresponding 800g of water, stir and heat up;

[0026] (2) Continue to stir, heat up to about 65°C, add 100g of quinocetone, and make it mix evenly;

[0027] (3) Then control the temperature to about 65°C, continue stirring, and keep warm for 60 minutes;

[0028] (4) After the heat preservation is completed, pour the obtained material into a baking tray and spread it evenly, put it in an oven for continuous drying for 3 hours, and the drying temperature is 90-100° C. to obtain a powdery quinocetone clathrate;

[0029] (5) cooling, crossing 60 mesh sieves with the cooled powdered quinocetone cyclodextrin inclusion compound;

[0030] (6) Sampling of the inclusion compound of quinone cyclodextrin to ...

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Abstract

The invention relates to water-soluble powder of a cyclodextrin clathrate of quinocetone and a preparation method thereof. The powder of the cyclodextrin clathrate solves the problems of water insolubility, low bioavailability, poor absorptivity and poor free-running property. The preparation method comprises blending quinocetone, cyclodextrin and water according to a mass percentage of 10: 30-50: 50-100 and carrying out inclusion reaction, drying, cooling and detection. The powder has the characteristics of a high drug dissolution rate, good solubility, high bioavailability and good absorption effects and has a growth rate obviously superior to that of the same amount of quinocetone. The powder has improved free-running properties and can be fast and uniformly mixed. The drug quinocetone is coated with a carrier material and the carrier material can cover a bitter taste of quinocetone so that animal ingestion or water drinking is not influenced by a drug bitter taste.

Description

1. Technical field [0001] The invention belongs to the technical field of pharmaceutical preparations, and in particular relates to a water-soluble powder preparation of a quinone cyclodextrin inclusion compound and a preparation method thereof. 2. Background technology [0002] Quinocetone is a new antibacterial, antidiarrheal, and growth-promoting drug for livestock and poultry newly developed by Lanzhou Institute of Animal Husbandry and Veterinary Medicine, Chinese Academy of Agricultural Sciences. The announcement approves its use in animal feed. [0003] The chemical name of quinocetone is: 3-methyl-2-cinnamoyl-quinoxaline-1,4-dioxide, and the molecular formula is C 18 h 14 N 2 o 3 , the molecular weight is 306.32, and the structural formula is as follows: [0004] [0005] Quinocetone is a yellow powder, insoluble in water, slightly soluble in some organic solvents, sensitive to light, and prone to photochemical reactions. Quinocetone belongs to quinoxaline dr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K9/14A61K47/48A61K31/498
Inventor 邹小军马宏星刘姣张誉赢冯建波汪丛珍夏清张玲
Owner CHINA ANIMAL HUSBANDRY IND
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